Sphondin

Modify Date: 2024-01-02 20:22:59

Sphondin Structure
Sphondin structure
 Common Name Sphondin
CAS Number 483-66-9 Molecular Weight 216.189
Density 1.4±0.1 g/cm3 Boiling Point 413.0±45.0 °C at 760 mmHg
Molecular Formula C12H8O4 Melting Point N/A
MSDS N/A Flash Point 203.6±28.7 °C

 Use of Sphondin


Sphondin, isolated from Heracleum laciniatum, possesses an inhibitory effect on IL-1β-induced increase in the level of COX-2 protein and PGE2 release in A549 cells[1].

 Names

Name 6-methoxyfuro[2,3-h]chromen-2-one
Synonym More Synonyms

 Sphondin Biological Activity

Description Sphondin, isolated from Heracleum laciniatum, possesses an inhibitory effect on IL-1β-induced increase in the level of COX-2 protein and PGE2 release in A549 cells[1].
Related Catalog
Target

COX-2

In Vitro Pretreatment of A549 cells with Sphondin (10-50 μM) concentration-dependently attenuates IL-1β-induced COX-2 protein expression and PGE2 release[1].
References

[1]. Ling Ling Yang, et al. Effects of Sphondin, Isolated From Heracleum Laciniatum, on IL-1beta-induced cyclooxygenase-2 Expression in Human Pulmonary Epithelial Cells. Life Sci. 2002 Nov 29;72(2):199-213.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 413.0±45.0 °C at 760 mmHg
Molecular Formula C12H8O4
Molecular Weight 216.189
Flash Point 203.6±28.7 °C
Exact Mass 216.042252
PSA 52.58000
LogP 1.83
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.635

 Safety Information

Hazard Codes Xi

 Synthetic Route

6-methoxy-2-oxo-3-(phenylthio)-(2,3,4H)-furo(2,3-h)(1)benzopyran structure

6-methoxy-2-oxo...

CAS#:116669-19-3

~82%

Sphondin Structure

Sphondin

CAS#:483-66-9

Literature: Wulff, William D.; McCallum, J. Stuart; Kunng, Fen-Ann Journal of the American Chemical Society, 1988 , vol. 110, # 22 p. 7419 - 7434
N/A structure

N/A

CAS#:116663-87-7

~50%

Sphondin Structure

Sphondin

CAS#:483-66-9

Literature: Wulff, William D.; McCallum, J. Stuart; Kunng, Fen-Ann Journal of the American Chemical Society, 1988 , vol. 110, # 22 p. 7419 - 7434
6-Hydroxy-2H-furo[2,3-h]-1-benzopyran-2-one structure

6-Hydroxy-2H-fu...

CAS#:61265-07-4

Dimethyl sulfate structure

Dimethyl sulfate

CAS#:77-78-1

~37%

Sphondin Structure

Sphondin

CAS#:483-66-9

Pimpinellin structure

Pimpinellin

CAS#:131-12-4

Literature: Sardari, Soroush; Mori, Yoki; Horita, Kiyoshi; Micetich, Ronald G.; Nishibe, Sansei; Daneshtalab, Mohsen Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 9 p. 1933 - 1940
N/A structure

N/A

CAS#:116663-85-5

~%

Sphondin Structure

Sphondin

CAS#:483-66-9

Literature: Wulff, William D.; McCallum, J. Stuart; Kunng, Fen-Ann Journal of the American Chemical Society, 1988 , vol. 110, # 22 p. 7419 - 7434
6-methoxy-3-(phenylsulfinyl)-3,4-dihydro-2H-furo[2,3-h]chromene structure

6-methoxy-3-(ph...

CAS#:116663-86-6

~%

Sphondin Structure

Sphondin

CAS#:483-66-9

Literature: Wulff, William D.; McCallum, J. Stuart; Kunng, Fen-Ann Journal of the American Chemical Society, 1988 , vol. 110, # 22 p. 7419 - 7434
6-(benzyloxy)-2H-furo[2,3-h]chromen-2-one structure

6-(benzyloxy)-2...

CAS#:250639-95-3

~%

Sphondin Structure

Sphondin

CAS#:483-66-9

Literature: Sardari, Soroush; Mori, Yoki; Horita, Kiyoshi; Micetich, Ronald G.; Nishibe, Sansei; Daneshtalab, Mohsen Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 9 p. 1933 - 1940
6-methoxy-7-(2-oxoethoxy)coumarinylaldehyde structure

6-methoxy-7-(2-...

CAS#:462094-30-0

~3%

Sphondin Structure

Sphondin

CAS#:483-66-9

Literature: Chimichi, Stefano; Boccalini, Marco; Cosimelli, Barbara; Viola, Giampietro; Vedaldi, Daniela; Dall'Acqua, Francesco Tetrahedron, 2002 , vol. 58, # 24 p. 4859 - 4863

 Synonyms

6-Methoxy-2H-furo[2,3-h]chromen-2-one
Sfondin
6-Methoxyfuro[2,3-h]chromen-2-one
2H-Furo[2,3-h]-1-benzopyran-2-one, 6-methoxy-
6-Methoxy-2H-furo(2,3-h)-1-benzopyran-2-one
Sphondin
6-Methoxy-furano-<2',3'-7,8>cumarin,Sphondin
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