(+)-Bicuculline

Modify Date: 2024-01-02 18:04:39

(+)-Bicuculline structure	Common Name	(+)-Bicuculline
	CAS Number	485-49-4	Molecular Weight	367.352
	Density	1.5±0.1 g/cm3	Boiling Point	542.3±50.0 °C at 760 mmHg
	Molecular Formula	C₂₀H₁₇NO₆	Melting Point	196-198 ºC
	MSDS	Chinese USA	Flash Point	281.8±30.1 °C
	Symbol	GHS06, GHS09	Signal Word	Danger

Use of (+)-Bicuculline

(+)-Bicuculline is a light-sensitive competitive antagonist of GABA-A receptor.

Name	bicuculline
Synonym	More Synonyms

Description	(+)-Bicuculline is a light-sensitive competitive antagonist of GABA-A receptor.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Signaling Pathways >> Neuronal Signaling >> GABA Receptor Natural Products >> Alkaloid Research Areas >> Others
References	[1]. Zahm DS, et al. Comparison of the locomotor-activating effects of bicuculline infusions into the preoptic area and ventral pallidum. Brain Struct Funct. 2014 Mar;219(2):511-26. [2]. Johnston GA. Advantages of an antagonist: bicuculline and other GABA antagonists. Br J Pharmacol. 2013 May;169(2):328-36.

Description

(+)-Bicuculline is a light-sensitive competitive antagonist of GABA-A receptor.

Related Catalog

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor

Signaling Pathways >> Neuronal Signaling >> GABA Receptor

Natural Products >> Alkaloid

Research Areas >> Others

References

[1]. Zahm DS, et al. Comparison of the locomotor-activating effects of bicuculline infusions into the preoptic area and ventral pallidum. Brain Struct Funct. 2014 Mar;219(2):511-26.

[2]. Johnston GA. Advantages of an antagonist: bicuculline and other GABA antagonists. Br J Pharmacol. 2013 May;169(2):328-36.

Density	1.5±0.1 g/cm3
Boiling Point	542.3±50.0 °C at 760 mmHg
Melting Point	196-198 ºC
Molecular Formula	C₂₀H₁₇NO₆
Molecular Weight	367.352
Flash Point	281.8±30.1 °C
Exact Mass	367.105591
PSA	66.46000
LogP	2.88
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.665

(+)-Bicuculline MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LV0909840

CHEMICAL NAME :: Furo(3,4-e)-1,3-benzodioxol-8(6H)-one, 6-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo(4,5-g) isoquinolin-5-yl)-, (R-(R*,S*))-

CAS REGISTRY NUMBER :: 485-49-4

BEILSTEIN REFERENCE NO. :: 0098786

LAST UPDATED :: 199801

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C20-H17-N-O6

MOLECULAR WEIGHT :: 367.38

WISWESSER LINE NOTATION :: T C566 DO FO KN EH&&TJ K1 J- ET B565 CVO JO LO EH KHJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8480 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CUTOEX Current Toxicology. (Nova Science Publishers, Inc., 6080 Jericho Turnpike, Suite 207, Commack, NY 11725) V.1 1993- Volume(issue)/page/year: 1,199,1993

Symbol	GHS06, GHS09
Signal Word	Danger
Hazard Statements	H300-H311 + H331-H400
Precautionary Statements	P261-P264-P273-P280-P301 + P310-P311
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes	T: Toxic;N: Dangerous for the environment;
Risk Phrases	R23/24/25
Safety Phrases	S36/37-S45-S61
RIDADR	UN 1544 6.1/PG 2
WGK Germany	3
RTECS	LV0909840
Packaging Group	III
Hazard Class	6.1(b)

Formaldehyde

CAS#:50-00-0

N/A

CAS#:185022-39-3

~81%

(+)-Bicuculline

CAS#:485-49-4

Literature: Kardos; Blandl; Luyen; Doernyei; Gacs-Baitz; Simonyi; Cash; Blasko; Szantay European Journal of Medicinal Chemistry, 1996 , vol. 31, # 10 p. 761 - 765

(+)-bicuculline

CAS#:56083-00-2

(+)-Bicuculline

CAS#:485-49-4

Literature: Haworth; Pinder; Robinson Nature (London, United Kingdom), 1950 , vol. 165, p. 529

Furo[3,4-e]-1,3...

CAS#:64395-07-9

(+)-Bicuculline

CAS#:485-49-4

Literature: Kardos; Blandl; Luyen; Doernyei; Gacs-Baitz; Simonyi; Cash; Blasko; Szantay European Journal of Medicinal Chemistry, 1996 , vol. 31, # 10 p. 761 - 765

5-formyl-1,3-be...

CAS#:58343-48-9

(+)-Bicuculline

CAS#:485-49-4

Literature: Kardos; Blandl; Luyen; Doernyei; Gacs-Baitz; Simonyi; Cash; Blasko; Szantay European Journal of Medicinal Chemistry, 1996 , vol. 31, # 10 p. 761 - 765

N/A

CAS#:1026278-40-9

(+)-Bicuculline

CAS#:485-49-4

Literature: Kardos; Blandl; Luyen; Doernyei; Gacs-Baitz; Simonyi; Cash; Blasko; Szantay European Journal of Medicinal Chemistry, 1996 , vol. 31, # 10 p. 761 - 765

N-(2-(benzo[d][...

CAS#:185022-35-9

(+)-Bicuculline

CAS#:485-49-4

Literature: Kardos; Blandl; Luyen; Doernyei; Gacs-Baitz; Simonyi; Cash; Blasko; Szantay European Journal of Medicinal Chemistry, 1996 , vol. 31, # 10 p. 761 - 765

Precursor 5
CAS#:50-00-0 Formaldehyde CAS#:56083-00-2 (+)-bicuculline CAS#:64395-07-9 Furo[3,4-e]-1,3... CAS#:58343-48-9 5-formyl-1,3-be...
CAS#:185022-35-9 N-(2-(benzo[d][...
DownStream 1
CAS#:40709-69-1 Bicuculline met...

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D-BICUCULLINE

EINECS 207-619-7

BICUCULLINE (+)

(+)-Bicuculline

PLUS-BICUCULLINE

bicucculine

(6R)-6-[(5S)-6-Methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl]furo[3,4-e][1,3]benzodioxol-8(6H)-one

MFCD00005006

Bicuculline

Furo[3,4-e]-1,3-benzodioxol-8(6H)-one, 6-[(5S)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, (6R)-

bicucullin

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China
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China
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China
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Price: $79/10mM*1mLinDMSO

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(+)-Bicuculline

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