7-Hydroxy-4'-methoxyflavone

Modify Date: 2024-01-31 19:11:51

7-Hydroxy-4'-methoxyflavone structure	Common Name	7-Hydroxy-4'-methoxyflavone
	CAS Number	487-24-1	Molecular Weight	268.26
	Density	1.329g/cm3	Boiling Point	479.4ºC at 760mmHg
	Molecular Formula	C₁₆H₁₂O₄	Melting Point	263-264ºC
	MSDS	N/A	Flash Point	183.4ºC

Use of 7-Hydroxy-4'-methoxyflavone

Pratol is a potent inhibitor of NF-κB. Pratol significantly reduces NO and prostaglandin PGE2 production without any cytotoxic in LPS-stimulated RAW 264.7 cells. Pratol reduces proinflammatory cytokines. Pratol can be used in study inflammatory diseases and cancer[1].

Name	7-hydroxy-2-(4-methoxyphenyl)chromen-4-one
Synonym	More Synonyms

Description	Pratol is a potent inhibitor of NF-κB. Pratol significantly reduces NO and prostaglandin PGE2 production without any cytotoxic in LPS-stimulated RAW 264.7 cells. Pratol reduces proinflammatory cytokines. Pratol can be used in study inflammatory diseases and cancer[1].
Related Catalog	Research Areas >> Inflammation/Immunology
References	[1]. Chung, Y. C. , et al. Anti-inflammatory Effect of Pratol in LPS-stimulated RAW 264.7 Cells via NF-κB Signaling Pathways. Natural Product Communications, 13(5), 1934578X1801300.

Density	1.329g/cm3
Boiling Point	479.4ºC at 760mmHg
Melting Point	263-264ºC
Molecular Formula	C₁₆H₁₂O₄
Molecular Weight	268.26
Flash Point	183.4ºC
Exact Mass	266.09400
PSA	39.44000
LogP	3.77700
Vapour Pressure	8.17E-10mmHg at 25°C
Index of Refraction	1.641

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DJ3100110

CHEMICAL NAME :: 4H-1-Benzopyran-4-one, 7-hydroxy-2-(4-methoxyphenyl)-

CAS REGISTRY NUMBER :: 487-24-1

BEILSTEIN REFERENCE NO. :: 0237239

LAST UPDATED :: 199709

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C16-H12-O4

MOLECULAR WEIGHT :: 268.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 38,67,1983