Pinoresinol

Modify Date: 2024-01-01 18:10:04

Pinoresinol Structure
Pinoresinol structure
Common Name Pinoresinol
CAS Number 487-36-5 Molecular Weight 358.385
Density 1.3±0.1 g/cm3 Boiling Point 556.5±50.0 °C at 760 mmHg
Molecular Formula C20H22O6 Melting Point 121 °C
MSDS USA Flash Point 290.4±30.1 °C

 Use of Pinoresinol


Pinoresinol is a lignol of plant origin serving for defense in a caterpillar. Pinoresinol drastically sensitizes cancer cells against TNF-related apoptosis-inducing ligand (TRAIL) -induced apoptosis[1][2].

 Names

Name (+)-pinoresinol
Synonym More Synonyms

 Pinoresinol Biological Activity

Description Pinoresinol is a lignol of plant origin serving for defense in a caterpillar. Pinoresinol drastically sensitizes cancer cells against TNF-related apoptosis-inducing ligand (TRAIL) -induced apoptosis[1][2].
Related Catalog
In Vitro Pinoresinol facilitated death-inducing signaling complex formation to trigger a caspase-8-dependent apoptotic cascade activation in TRAIL-resistant glioblastoma cells[2].
References

[1]. Schroeder FC, et al. Pinoresinol: A lignol of plant origin serving for defense in a caterpillar. Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15497-501.

[2]. Lee SR, et al. Accelerated degradation of cFLIPL and sensitization of the TRAIL DISC-mediated apoptotic cascade by pinoresinol, a lignan isolated from Rubia philippinensis. Sci Rep. 2019 Sep 18;9(1):13505.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 556.5±50.0 °C at 760 mmHg
Melting Point 121 °C
Molecular Formula C20H22O6
Molecular Weight 358.385
Flash Point 290.4±30.1 °C
Exact Mass 358.141632
PSA 77.38000
LogP 1.54
Appearance of Characters white to tan
Vapour Pressure 0.0±1.6 mmHg at 25°C
Index of Refraction 1.598
Storage condition ?20°C
Water Solubility DMSO: ≥6mg/mL

 Safety Information

Hazard Codes Xi
RIDADR NONH for all modes of transport

 Articles26

More Articles
Characterisation and phenolic profiles of two rare olive oils from southern Tunisia: Dhokar and Gemri-Dhokar cultivars.

J. Sci. Food Agric. 93(3) , 527-34, (2013)

The aim of this work was to study the chemical characteristics of two Tunisian cultivars, namely Dhokar and Gemri-Dhokar, to analyse the fatty acids, sterols, triacylglycerols, triterpenic alcohols, a...

[Study on the chemical constituents of the roots of Dendropanax chevalieri].

Zhong Yao Cai 35(1) , 62-4, (2012)

To study the chemical constituents of the roots of Dendropanax chevalieri.The constituents were isolated by column chromatography with silica gel, Sephadex LH-20 gel and RP-18. Their structures were e...

[Chemical constituents of the roots of Vaccinium bracteatum].

Zhong Yao Cai 35(6) , 917-9, (2012)

To study the chemical constituents of the roots of Vaccinium bracteatum.The constituents were separated and purified with chromatographic methods (including silica gel, Sephadex LH-20 and RP-18 column...

 Synonyms

(+)-PINORESINOL
4,4'-(1S,3aR,4S,6aR)-Tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diylbis(2-methoxyphenol)
Phenol, 4,4'-[(1S,3aR,4S,6aR)-tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl]bis[2-methoxy-
Pinoresinol
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