Vinburnine

Modify Date: 2024-01-02 20:22:55

Vinburnine Structure
Vinburnine structure
Common Name Vinburnine
CAS Number 4880-88-0 Molecular Weight 294.391
Density 1.3±0.1 g/cm3 Boiling Point 441.9±33.0 °C at 760 mmHg
Molecular Formula C19H22N2O Melting Point 174-177 °C(lit.)
MSDS N/A Flash Point 221.0±25.4 °C

 Use of Vinburnine


Vincamone is a vinca alkaloid and a metabolite of vincamine, is a vasodilator.

 Names

Name (-)-Eburnamonine
Synonym More Synonyms

 Vinburnine Biological Activity

Description Vincamone is a vinca alkaloid and a metabolite of vincamine, is a vasodilator.
Related Catalog

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 441.9±33.0 °C at 760 mmHg
Melting Point 174-177 °C(lit.)
Molecular Formula C19H22N2O
Molecular Weight 294.391
Flash Point 221.0±25.4 °C
Exact Mass 294.173218
PSA 25.24000
LogP 3.79
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.719
Storage condition -20℃

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YY8575570
CHEMICAL NAME :
Vincamone
CAS REGISTRY NUMBER :
4880-88-0
LAST UPDATED :
199703
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C19-H22-N2-O
MOLECULAR WEIGHT :
294.43

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3852453
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
265 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 14,160,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
28 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 14,160,1978

 Safety Information

Safety Phrases S22-S24/25
WGK Germany 2
RTECS YY8575570
HS Code 2933990090

 Synthetic Route

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

Eburnamenin-14-one, 14,15-dihydro-, (3α,16α)-
(13aS,13bS)-13a-éthyl-2,3,6,13,13a,13b-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij]-1,5-naphtyridin-12(5H)-one
(3α,16α)-14,15-Dihydroeburnamenin-14-one
3a,16a-Eburnamonine
vinburnine
(-)-EBURNAMONINE
(3a,16a)-Eburnamenin-14(15H)-one
(13aS,13bS)-13a-Ethyl-2,3,6,13,13a,13b-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridin-12(5H)-one
Eburnamenin-14(15H)-one, (3α,16α)-
Vincamone
MFCD00064309
16-Oxoeburnane
(3a,16a)-Eburnamin-14(15H)-one
EINECS 225-490-5
(13aS,13bS)-13a-Ethyl-2,3,6,13,13a,13b-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij]-1,5-naphthyridin-12(5H)-on
cis-Vincamone
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