Vincamine

Modify Date: 2024-01-02 18:40:03

Vincamine structure	Common Name	Vincamine
	CAS Number	1617-90-9	Molecular Weight	354.443
	Density	1.4±0.1 g/cm3	Boiling Point	508.9±50.0 °C at 760 mmHg
	Molecular Formula	C₂₁H₂₆N₂O₃	Melting Point	232ºC (dec.)
	MSDS	Chinese USA	Flash Point	261.6±30.1 °C
	Symbol	GHS07	Signal Word	Warning

Use of Vincamine

Vincamine is a peripheral vasodilator, that increases blood flow to the brain.

Name	vincamine
Synonym	More Synonyms

Description	Vincamine is a peripheral vasodilator, that increases blood flow to the brain.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cardiovascular Disease Natural Products >> Alkaloid

Density	1.4±0.1 g/cm3
Boiling Point	508.9±50.0 °C at 760 mmHg
Melting Point	232ºC (dec.)
Molecular Formula	C₂₁H₂₆N₂O₃
Molecular Weight	354.443
Flash Point	261.6±30.1 °C
Exact Mass	354.194336
PSA	54.70000
LogP	3.10
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.682
Storage condition	2~8°C

Vincamine MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YY8575000

CHEMICAL NAME :: Vincamine

CAS REGISTRY NUMBER :: 1617-90-9

LAST UPDATED :: 199706

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C21-H26-N2-O3

MOLECULAR WEIGHT :: 354.49

WISWESSER LINE NOTATION :: T D6 B5666 2AB S CN MN&&TTTJ Q2 SVO1 SQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3852453

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 253 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 32,601,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 460 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4011330

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 195 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EPXXDW European Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #0052238

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 47740 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AGSOA6 Agressologie. Revue Internationale de Physio-Biologie et de Pharmacologie Appliquees aux Effets de l'Agression. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1960- Volume(issue)/page/year: 19,211,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 33 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 236,296,1959

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Precautionary Statements	P301 + P312 + P330
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful;
Risk Phrases	R22
Safety Phrases	S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	YY8575000

Precursor 6
CAS#:85588-92-7 (-)-methyl 1,2,... CAS#:67-56-1 Methanol CAS#:35226-43-8 (3α,16α)-D-homo... CAS#:61-54-1 tryptamine
CAS#:14487-98-0 ethyl 3-((2-(1H... CAS#:190378-09-7 5-ethyl-1-[2-(1...
DownStream 5
CAS#:4880-88-0 Vinburnine CAS#:6835-99-0 3α-epivincamine CAS#:42971-09-5 Vinpocetine CAS#:3382-95-4 Vincaminol
CAS#:1617-90-9 Vincamine

Mechanochemical activation of vincamine mediated by linear polymers: assessment of some "critical" steps.

Eur. J. Pharm. Sci. 50(1) , 56-68, (2013)

The aim of the research was to investigate three "critical steps" that deserve particular attention during the mechanochemical activation of vincamine. The first step consisted in the selection of the...

Determination of terpenoid indole alkaloids in hairy roots of Rhazya stricta (Apocynaceae) by GC-MS.

Phytochem. Anal. 26 , 331-8, (2015)

Rhazya stricta Decne. (Apocynaceae) is a medicinal plant rich in terpenoid indole alkaloids (TIAs), some of which possess important pharmacological properties. The study material including transgenic ...

Plasma Pharmacokinetics of Polyphenols in a Traditional Japanese Medicine, Jumihaidokuto, Which Suppresses Propionibacterium acnes-Induced Dermatitis in Rats.

Molecules 20 , 18031-46, (2015)

Most orally administered polyphenols are metabolized, with very little absorbed as aglycones and/or unchanged forms. Metabolic and pharmacokinetic studies are therefore necessary to understand the pha...

EINECS 216-576-3

Methyl (12S,13aS,13bS)-13a-ethyl-12-hydroxy-2,3,5,6,12,13,13a,13b-octahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate

vincamine

(12S,13aS,13bS)-13a-éthyl-12-hydroxy-2,3,5,6,12,13,13a,13b-octahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij]-1,5-naphtyridine-12-carboxylate de méthyle

(3a,14b,16a)-14,15-Dihydro-14-hydroxyeburnamenine-14-carboxylic Acid Methyl Ester

Pervone

Vraap

Methyl-(12S,13aS,13bS)-13a-ethyl-12-hydroxy-2,3,5,6,12,13,13a,13b-octahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij]-1,5-naphthyridin-12-carboxylat

Angiopac

Perval

Equipur

MFCD00078054

Vinca

Minorin

methyl 14-hydroxy-14,15-dihydroeburnamenine-14-carboxylate

Monorin

Decincan

Methyl (3α,14β,16α)-14-hydroxy-14,15-dihydroeburnamenine-14-carboxylate

Novicet

Eburnamenine-14-carboxylic acid, 14,15-dihydro-14-hydroxy-, methyl ester, (3α,14β,16α)-

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Vincamine
Price: Click To Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Vincamine
Price: ￥228.0/20mg
Purity: 98.0%
Delivery: 2 Day
Contact: Liu jia
Email: 2130147988@qq.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Vincamine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: vincamine
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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Price: $66/10mM*1mLinDMSO

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Vincamine

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