estramustine phosphate

Modify Date: 2024-01-02 17:11:44

estramustine phosphate structure	Common Name	estramustine phosphate
	CAS Number	4891-15-0	Molecular Weight	520.38300
	Density	1.4g/cm3	Boiling Point	661.2ºC at 760mmHg
	Molecular Formula	C₂₃H₃₂Cl₂NO₆P	Melting Point	N/A
	MSDS	N/A	Flash Point	353.7ºC

Use of estramustine phosphate

Estramustine phosphate, an estradiol analog, is an orally active antimicrotubule chemotherapy agent. Estramustine phosphate depolymerises microtubules by binding to microtubule associated proteins (MAPs) and/or to tubulin. Estramustine phosphate can interfere mitosis, trigger cell death and induce apoptosis, which can be used for the research of cancer like prostate cancer[1][2][3].

Name	estramustine phosphate
Synonym	More Synonyms

Description	Estramustine phosphate, an estradiol analog, is an orally active antimicrotubule chemotherapy agent. Estramustine phosphate depolymerises microtubules by binding to microtubule associated proteins (MAPs) and/or to tubulin. Estramustine phosphate can interfere mitosis, trigger cell death and induce apoptosis, which can be used for the research of cancer like prostate cancer[1][2][3].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Endocrinology Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Research Areas >> Inflammation/Immunology Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin
In Vitro	Estramustine phosphate (1 µg/mL, 48 h) suppresses PC3 cell growth[1]. Estramustine phosphate (2 µg/mL, 48 h) elevates phosphatidylserine eversion amount on PC3 cells and induces PC3 cell apoptosis through reducing miR-31[1]. Estramustine phosphate (0-40 µM, 24-72 h) inhibits cell proliferation and tubulin cytoskeleton in RAW 264.7 cells[2]. Estramustine phosphate (10 µM, 24 h) inhibits TGF-β-induced RAW 264.7 cell migration, as well as TGF-β-induced uPA production by inhibiting Smad3 activation[2]. Cell Viability Assay[1] Cell Line: PC3 cells Concentration: 1 µg/ mL Incubation Time: 48 h Result: Suppressed PC3 cell growth. Immunofluorescence[2] Cell Line: RAW 264.7 cells Concentration: 10 µM Incubation Time: 24 h Result: Disrupted the interphase microtubules. Cell Migration Assay [2] Cell Line: 18 h of TGF-β treated RAW 264.7 cells Concentration: 10 µM Incubation Time: 24 h Result: Inhibited TGF-β-Induced Cell Migration.
In Vivo	Estramustine phosphate (Intraperitoneal injection, 4 or 12 mg/kg, a daily dose for 2 weeks) inhibits PAC120 tumor growth 53% by day 35[3]. Animal Model: Human prostate cancer xenograft PAC120[3] Dosage: 4 or 12 mg/kg, a daily dose for 2 weeks. Administration: Intraperitoneal injection Result: Inhibited PAC120 tumor growth 53% by day 35.
References	[1]. C Wei, et al. Estramustine phosphate induces prostate cancer cell line PC3 apoptosis by down-regulating miR-31 levels. Eur Rev Med Pharmacol Sci. 2018 Jan;22(1):40-45. [2]. Sonja S Mojsilovic, et al. Estramustine Phosphate Inhibits TGF- β-Induced Mouse Macrophage Migration and Urokinase-Type Plasminogen Activator Production. Anal Cell Pathol (Amst). 2018 Sep 2;2018:3134102. [3]. Stephane Oudard, et al. Activity of docetaxel with or without estramustine phosphate versus mitoxantrone in androgen dependent and independent human prostate cancer xenografts. J Urol. 2003 May;169(5):1729-34.

Density	1.4g/cm3
Boiling Point	661.2ºC at 760mmHg
Molecular Formula	C₂₃H₃₂Cl₂NO₆P
Molecular Weight	520.38300
Flash Point	353.7ºC
Exact Mass	519.13400
PSA	106.11000
LogP	5.29900
Index of Refraction	1.594

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KG4300000

CHEMICAL NAME :: Estradiol, 3-(bis(2-chloroethyl)carbamate) dihydrogen phosphate

CAS REGISTRY NUMBER :: 4891-15-0

LAST UPDATED :: 199707

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C23-H32-Cl2-N-O6-P

MOLECULAR WEIGHT :: 520.43

WISWESSER LINE NOTATION :: L E5 B666TTT&J E1 FOPQQO OOVN2G2G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 1000 ug/plate

REFERENCE :: URLRA5 Urological Research. (Springer Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1973- Volume(issue)/page/year: 7,119,1979

LS 299

[(8R,9S,13S,14S,17S)-13-methyl-17-phosphonooxy-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl] N,N-bis(2-chloroethyl)carbamate

ESTRAMUSTINE PHOSPHATE

Leo 299

Emcyt (free acid)

(17|A)-17-(phosphonooxy)estra-1,3,5(10)-trien-3-yl bis(2-chloroethyl)carbamate

Estradiol,3-(bis(2-chloroethyl)carbamate) dihydrogen phosphate

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Estramustine phosphate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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