BI-0115
Modify Date: 2024-01-16 08:57:17
BI-0115 structure
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Common Name | BI-0115 | ||
|---|---|---|---|---|
| CAS Number | 4929-23-1 | Molecular Weight | 287.744 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 489.2±45.0 °C at 760 mmHg | |
| Molecular Formula | C15H14ClN3O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 249.7±28.7 °C | |
Use of BI-0115BI-0115 is a selective inhibitor of LOX-1 (IC50=5.4 µM) that blocks cellular uptake of oxLDL. BI-0115 binding triggers receptor inhibition by formation of dimers of the homodimeric ligand binding domain[1]. |
| Name | 9-Chloro-5-propyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one |
|---|---|
| Synonym | More Synonyms |
| Description | BI-0115 is a selective inhibitor of LOX-1 (IC50=5.4 µM) that blocks cellular uptake of oxLDL. BI-0115 binding triggers receptor inhibition by formation of dimers of the homodimeric ligand binding domain[1]. |
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| Related Catalog | |
| In Vitro | BI-0115 efficiently reduces oxLDL internalization in the cellular context. The IC50 values of the cellular assay (5.4 µM) are in good agreement with the determined Kd values in SPR (4.3 µM) and ITC (6.99 µM)[1]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 489.2±45.0 °C at 760 mmHg |
| Molecular Formula | C15H14ClN3O |
| Molecular Weight | 287.744 |
| Flash Point | 249.7±28.7 °C |
| Exact Mass | 287.082550 |
| LogP | 3.08 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.602 |
| 6H-Pyrido[2,3-b][1,4]benzodiazepin-6-one, 9-chloro-5,11-dihydro-5-propyl- |
| 9-Chloro-5-propyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one |