2-(Benzyloxy)ethanol

Modify Date: 2025-08-21 11:39:40

2-(Benzyloxy)ethanol structure	Common Name	2-(Benzyloxy)ethanol
	CAS Number	622-08-2	Molecular Weight	152.190
	Density	1.1±0.1 g/cm3	Boiling Point	254.4±15.0 °C at 760 mmHg
	Molecular Formula	C₉H₁₂O₂	Melting Point	<-75ºC
	MSDS	Chinese USA	Flash Point	108.0±14.6 °C
	Symbol	GHS07	Signal Word	Warning

Use of 2-(Benzyloxy)ethanol

2-(Benzyloxy)ethanol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

Name	2-Benzyloxyethanol
Synonym	More Synonyms

Description	2-(Benzyloxy)ethanol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. Reed NN, et al. A one-step synthesis of monoprotected polyethylene glycol ethers. J Org Chem. 2000 Sep 8;65(18):5843-5.

Density	1.1±0.1 g/cm3
Boiling Point	254.4±15.0 °C at 760 mmHg
Melting Point	<-75ºC
Molecular Formula	C₉H₁₂O₂
Molecular Weight	152.190
Flash Point	108.0±14.6 °C
Exact Mass	152.083725
PSA	29.46000
LogP	1.38
Vapour Pressure	0.0±0.5 mmHg at 25°C
Index of Refraction	1.525

2-(Benzyloxy)ethanol MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KJ7550000

CHEMICAL NAME :: Ethanol, 2-(benzyloxy)-

CAS REGISTRY NUMBER :: 622-08-2

BEILSTEIN REFERENCE NO. :: 2043566

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C9-H12-O2

MOLECULAR WEIGHT :: 152.21

WISWESSER LINE NOTATION :: Q2O1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 29,1363,1946 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1190 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic Gastrointestinal - other changes Kidney, Ureter, Bladder - other changes

REFERENCE :: JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 23,259,1941

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xn:Harmful;
Risk Phrases	R22;R36/37/38
Safety Phrases	S26-S36-S37/39
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	KJ7550000
HS Code	2909499000

Precursor 9
CAS#:100-39-0 Benzyl bromide CAS#:107-21-1 Ethylene glycol CAS#:100-44-7 Benzyl chloride CAS#:936-51-6 2-phenyl-1,3-di...
CAS#:60656-87-3 2-(Benzyloxy)ac... CAS#:31600-43-8 Methyl 2-(benzy... CAS#:96-49-1 Ethylene carbonate CAS#:106-44-5 p-Cresol
CAS#:122-99-6 Phenoxyethanol
DownStream 10
CAS#:38336-04-8 2-benzyloxyethy... CAS#:420137-14-0 3-Benzyloxypyrr... CAS#:936-51-6 2-phenyl-1,3-di... CAS#:23043-24-5 p-Toluidine, al...
CAS#:2050-25-1 Diethylene Glyc... CAS#:107-21-1 Ethylene glycol CAS#:82166-21-0 2-methyl cyclohexane CAS#:1462-37-9 Benzyl 2-Bromoe...
CAS#:100-39-0 Benzyl bromide CAS#:86259-87-2 Tetraethylene G...

HS Code	2909499000
Summary	2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

Alkylation of active methylene compounds with alcohols catalyzed by an iridium complex.

Chem. Commun. (Camb.) , 2850, (2007)

Base-free catalytic alpha-alkylation of active methylene compounds with primary alcohols was successfully achieved using an [IrCl(cod)](2) complex in the presence of PPh(3) to afford the corresponding...

A structure-based library approach to kinase inhibitors. Norman TC, et al.

J. Am. Chem. Soc. 118(31) , 7430-31, (1996)

Poly (benzyloxy ethyl methacrylate): preparation by free radical polymerization and by group transfer polymerization; with subsequent debenzylation to form poly (2-hydroxyethyl methacrylate). Dyakonov TA, et al.

Eur. Polymer J. 36(9) , 1779-93, (2000)

2-(Benzyloxy)ethanol

Ethanol, 2- (benzyloxy)-

2-(Benzyl-Oxy)Ethan-1-Ol

MFCD00002868

2-phenylmethoxyethanol

Benzyl cellosolve

Ethanol, 2-(phenylmethoxy)-

Glycol benzyl ether

UNII-06S8147L47

EINECS 210-719-3

ethylene glycol monobenzyl ether

Ethanol, 2- (phenylmethoxy)-

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China
Product Name: 2-(Benzyloxy)ethanol
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2-(Benzyloxy)ethanol

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