kojic acid
kojic acid structure
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Common Name | kojic acid | ||
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| CAS Number | 501-30-4 | Molecular Weight | 142.11 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 401.7±45.0 °C at 760 mmHg | |
| Molecular Formula | C6H6O4 | Melting Point | 152-155 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 179.9±22.2 °C | |
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Ciprofloxacin containing Mannich base and its copper complex induce antitumor activity via different mechanism of action.
Int. J. Oncol. 45(5) , 2092-100, (2014) The Mannich base containing ciprofloxacin and kojic acid structural units was prepared and evaluated in antitumor activity. The enhancement in antitumor activity was observed both from the Mannich base (IC(50): 103.3±5.0 µM for HepG2, 87.9±8.0 µM for HCT-116 ... |
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Design, synthesis, and anti-melanogenic effects of (E)-2-benzoyl-3-(substituted phenyl)acrylonitriles.
Drug Des. Devel. Ther. 9 , 4259-68, (2015) Tyrosinase is the most prominent target for inhibitors of hyperpigmentation because it plays a critical role in melaninogenesis. Although many tyrosinase inhibitors have been identified, from both natural and synthetic sources, there remains a considerable de... |
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Chemical compositions and biological activities of the essential oils of Beilschmiedia madang Blume (Lauraceae).
Arch. Pharm. Res. 38(4) , 485-93, (2015) The present study aimed to examine the chemical compositions of the essential oils of Beilschmiedia madang and their antioxidant, antibacterial, antifungal, anticholinesterase and anti-tyrosinase activities. The major constituents of the essential oils of lea... |
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Chemical Compositions and Biological Activities of Essential Oils of Beilschmiedia glabra.
Nat. Prod. Commun. 10 , 1297-300, (2015) This study was designed to examine the chemical compositions of essential oils from Beilschmiedia glabra and their antioxidant, antimicrobial, antityrosinase, acetylcholinesterase and anti-inflammatory activities. In total, 47 components were identified in th... |
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Identifying chelators for metalloprotein inhibitors using a fragment-based approach.
J. Med. Chem. 54 , 591-602, (2011) Fragment-based lead design (FBLD) has been used to identify new metal-binding groups for metalloenzyme inhibitors. When screened at 1 mM, a chelator fragment library (CFL-1.1) of 96 compounds produced hit rates ranging from 29% to 43% for five matrix metallop... |
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Determination of kojic acid in a skin-whitening cosmetic by high-performance liquid chromatography coupled with ultraviolet detection after pre-column derivatization with 4-fluoro-7-nitro-2,1,3-benzoxadiazole.
J. Cosmet. Sci. 63(3) , 205-12, (2012) Various methods for the determination of kojic acid (KA), a skin-whitening agent, have been reported by high-performance liquid chromatography (HPLC). In this study, the concentration of KA in a skin-whitening cosmetic was analyzed by HPLC with ultraviolet de... |
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Extract from Ceratonia siliqua Exhibits Depigmentation Properties.
Phytother Res. 29 , 1729-36, (2015) Skin hyper-pigmentation is a condition initiated by the overproduction of melanin existing in the melanocytes. Melanin pigment is responsible for the colour of skin in humans. It is formed through a series of oxidative reactions involving the amino acid tyros... |
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Structural insights into the hot spot amino acid residues of mushroom tyrosinase for the bindings of thujaplicins.
Bioorg. Med. Chem. 18 , 8112-8, (2010) Tyrosinase inhibitors are important agents for cosmetic products. We examined here the inhibitory effects of three isomers of thujaplicins (α, β and γ) on mushroom tyrosinase and analyzed their binding modes using a homology model from the crystal structure o... |
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Molecular modifications on carboxylic acid derivatives as potent histone deacetylase inhibitors: Activity and docking studies.
Bioorg. Med. Chem. 17 , 5219-28, (2009) In the light of known HDAC inhibitors, 33 carboxylic acid derivatives were tested to understand the structural requirements for HDAC inhibition activity. Several modifications were applied to develop the structure-activity relationships of carboxylic acid HDA... |
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Preparation, characterization, and preliminary antibrowning evaluations of norartocarpetin microemulsions.
J. Agric. Food Chem. 63(5) , 1615-21, (2015) Norartocarpetin is a flavone widely distributed in Moraceae plants with strong tyrosinase inhibitory activity. However, its poor solubility in aqueous systems and in food grade solvents (oils) limits its extensive applications. The aim of this study was to im... |