Vinclozoline

Modify Date: 2024-01-07 15:10:52

Vinclozoline Structure
Vinclozoline structure
 Common Name Vinclozoline
CAS Number 50471-44-8 Molecular Weight 286.111
Density 1.5±0.1 g/cm3 Boiling Point 369.9±52.0 °C at 760 mmHg
Molecular Formula C12H9Cl2NO3 Melting Point 108ºC
MSDS Chinese USA Flash Point 177.5±30.7 °C
Symbol GHS07 GHS08 GHS09
GHS07, GHS08, GHS09		 Signal Word Danger

 Names

Name vinclozolin
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 369.9±52.0 °C at 760 mmHg
Melting Point 108ºC
Molecular Formula C12H9Cl2NO3
Molecular Weight 286.111
Flash Point 177.5±30.7 °C
Exact Mass 284.995941
PSA 46.61000
LogP 3.19
Vapour Pressure 0.0±0.8 mmHg at 25°C
Index of Refraction 1.640

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RP8530000
CHEMICAL NAME :
2,4-Oxazolidinedione, 3-(3,5-dichlorophenyl)-5-methyl-5-vinyl-
CAS REGISTRY NUMBER :
50471-44-8
LAST UPDATED :
199701
DATA ITEMS CITED :
15
MOLECULAR FORMULA :
C12-H9-Cl2-N-O3
MOLECULAR WEIGHT :
286.12
WISWESSER LINE NOTATION :
T5OVNV EHJ CR CG EG& E1U1 E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>29100 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1170 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
8 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
7700 mg/kg/11W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in bladder weight Endocrine - changes in adrenal weight Related to Chronic Data - changes in testicular weight
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - quail
DOSE/DURATION :
1134 mg/kg/7D-C
TOXIC EFFECTS :
Liver - changes in liver weight Gastrointestinal - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1100 mg/kg
SEX/DURATION :
female 14-21 day(s) after conception lactating female 3 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - germ cell effects (in offspring)

MUTATION DATA

TYPE OF TEST :
Morphological transformation
TEST SYSTEM :
Rodent - mouse Fibroblast
DOSE/DURATION :
25 mg/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 21,81,1993 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989

 Safety Information

Symbol GHS07 GHS08 GHS09
GHS07, GHS08, GHS09
Signal Word Danger
Hazard Statements H317-H351-H360-H411
Precautionary Statements P201-P273-P280-P308 + P313
Personal Protective Equipment Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes T,N,Xn,F
Risk Phrases 60-61-40-43-51/53-36-20/21/22-11
Safety Phrases 53-45-61-36-26-16
RIDADR UN3077 9/PG 3
RTECS RP8530000
Packaging Group II
Hazard Class 3
HS Code 2934999039

 Customs

HS Code 2934999039
Summary 2934999039 3,5-dimethyl-1,3,5-thiadiazinane-2-thione。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:20.0%

 Articles42

More Articles
Anti-androgen vinclozolin impairs sperm quality and steroidogenesis in goldfish.

Aquat. Toxicol. 122-123 , 181-7, (2012)

In mammals, vinclozolin (VZ) is known as anti-androgen, which causes male infertility via androgen receptor (AR) antagonism. In aquatic animals, the VZ effects on reproductive functions are largely un...

LC-MS analysis of the plasma metabolome--a novel sample preparation strategy.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 978-979 , 83-8, (2015)

Blood plasma is a well-known body fluid often analyzed in studies on the effects of toxic compounds as physiological or chemical induced changes in the mammalian body are reflected in the plasma metab...

Extending an in vitro panel for estrogenicity testing: the added value of bioassays for measuring antiandrogenic activities and effects on steroidogenesis.

Toxicol. Sci. 141(1) , 78-89, (2014)

In the present study, a previously established integrated testing strategy (ITS) for in vitro estrogenicity testing was extended with additional in vitro assays in order to broaden its sensitivity to ...

 Synonyms

rac-(5R)-3-(3,5-dichlorophenyl)-5-ethenyl-5-methyl-1,3-oxazolidine-2,4-dione
Caswell No. 323C
2,4-Oxazolidinedione, 3-(3,5-dichlorophenyl)-5-ethenyl-5-methyl-
Vinclozoline
Vinchlozoline
(RS)-3-(3,5-dichlorophenyl)-5-methyl-5-vinyl-1,3-oxazolidine-2,4-dione
Ronilan
3-(3,5-dichlorophenyl)-5-ethenyl-5-methyl-1,3-oxazolidine-2,4-dione
Ornalin
3-(3,5-Dichloro-phenyl)-5-methyl-5-vinyl-oxazolidine-2,4-dione
UNII:JJ258EZN1I
3-(3,5-Dichlorophényl)-5-éthènyl-5-méthyl-1,3-oxazolidine-2,4-dione
3-(3,5-Dichlorophenyl)-5-methyl-5-vinyloxazolidine-2,4-dione
Vorlan
MFCD00055511
Vinclozolin
3-(3,5-Dichlorophenyl)-5-methyl-5-vinyl-1,3-oxazolidine-2,4-dione
3-(3,5-dichlorophenyl)-5-ethenyl-5-methyl-2,4-oxazolidinedione
EINECS 256-599-6
BAS 352F
Vinclozolin solution
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