Vinclozoline
Vinclozoline structure
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Common Name | Vinclozoline | ||
|---|---|---|---|---|
| CAS Number | 50471-44-8 | Molecular Weight | 286.111 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 369.9±52.0 °C at 760 mmHg | |
| Molecular Formula | C12H9Cl2NO3 | Melting Point | 108ºC | |
| MSDS | Chinese USA | Flash Point | 177.5±30.7 °C | |
| Symbol |
GHS07, GHS08, GHS09 |
Signal Word | Danger | |
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Anti-androgen vinclozolin impairs sperm quality and steroidogenesis in goldfish.
Aquat. Toxicol. 122-123 , 181-7, (2012) In mammals, vinclozolin (VZ) is known as anti-androgen, which causes male infertility via androgen receptor (AR) antagonism. In aquatic animals, the VZ effects on reproductive functions are largely unknown and results are somewhat contradictory. To understand... |
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LC-MS analysis of the plasma metabolome--a novel sample preparation strategy.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 978-979 , 83-8, (2015) Blood plasma is a well-known body fluid often analyzed in studies on the effects of toxic compounds as physiological or chemical induced changes in the mammalian body are reflected in the plasma metabolome. Sample preparation prior to LC-MS based analysis of ... |
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Extending an in vitro panel for estrogenicity testing: the added value of bioassays for measuring antiandrogenic activities and effects on steroidogenesis.
Toxicol. Sci. 141(1) , 78-89, (2014) In the present study, a previously established integrated testing strategy (ITS) for in vitro estrogenicity testing was extended with additional in vitro assays in order to broaden its sensitivity to different modes of action resulting in apparent estrogenici... |
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Deleterious effects of endocrine disruptors are corrected in the mammalian germline by epigenome reprogramming.
Genome Biol. 16 , 59, (2015) Exposure to environmental endocrine-disrupting chemicals during pregnancy reportedly causes transgenerationally inherited reproductive defects. We hypothesized that to affect the grandchild, endocrine-disrupting chemicals must alter the epigenome of the germ ... |
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Environmental contaminants activate human and polar bear (Ursus maritimus) pregnane X receptors (PXR, NR1I2) differently.
Toxicol. Appl. Pharmacol. 284(1) , 54-64, (2015) Many persistent organic pollutants (POPs) accumulate readily in polar bears because of their position as apex predators in Arctic food webs. The pregnane X receptor (PXR, formally NR1I2, here proposed to be named promiscuous xenobiotic receptor) is a xenobiot... |
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Alternations in neuroendocrine and endocrine regulation of reproduction in male goldfish (Carassius auratus) following an acute and chronic exposure to vinclozolin, in vivo.
Aquat. Toxicol. 155 , 73-83, (2014) The fungicide vinclozolin (VZ) is in use globally and known to disrupt reproductive function in male. The present study tested the hypothesis that VZ disrupts testicular function in goldfish (Carassius auratus) by affecting brain-pituitary-testis axis. Goldfi... |
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Mining biologically-active molecules for inhibitors of fatty acid amide hydrolase (FAAH): Identification of phenmedipham and amperozide as FAAH inhibitors
Bioorg. Med. Chem. Lett. 19 , 6793-6, (2009) The screening of known medicinal agents against new biological targets has been shown to be a valuable approach for revealing new pharmacology of marketed compounds. Recently, carbamate, urea and ketone inhibitors of fatty acid amide hydrolase (FAAH) have bee... |
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Antiandrogenic mechanisms of pesticides in human LNCaP prostate and H295R adrenocortical carcinoma cells.
Toxicol. Sci. 143(1) , 126-35, (2014) Several pesticides suspected or known to have endocrine disrupting effects were screened for pro- or antiandrogenic properties by determining their effects on proliferation, prostatic-specific antigen (PSA) secretion and androgen receptor (AR) expression, and... |
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Assessment of estrogenic and anti-androgenic activities of the mycotoxin zearalenone and its metabolites using in vitro receptor-specific bioassays.
Food Chem. Toxicol. 74 , 233-9, (2015) Zearalenone (ZEN) is a well-known mycotoxin present in numerous agricultural products. Humans and animals are therefore at a risk of exposure to zearalenone through consumption of contaminated food. After intake, ZEN is reduced to α- and β-zearalenol (α-ZEL a... |
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Effects of pesticides used in agriculture on the development of precocious puberty.
Environ. Monit. Assess. 184(7) , 4223-32, (2012) The present study aims to evaluate the effects of pesticides on premature breast development. Forty-five girls (group 1) with premature breast development living in the Menderes region, where greenhouse cultivation is the main income, 16 girls (group 2) livin... |