IRAK4-IN-16
Modify Date: 2025-08-26 12:30:10
IRAK4-IN-16 structure
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Common Name | IRAK4-IN-16 | ||
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| CAS Number | 509093-72-5 | Molecular Weight | 478.519 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C27H25F3N4O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of IRAK4-IN-16A potent, selective, and orally bioavailable inhibitor of interleukin-1 receptor-associate kinase-4 (IRAK4) with IC50 of 2.8 nM, 217- and 892-fold selectivity over IRAK-1 and TAK1, respectively; inhibits IL-1 induced activation of NF-kB in primary human monocytes with IC50 of 0.3 uM, possesses excellent selectivity and pharmacokinetic properties. |
| Name | IRAK4-IN-16 |
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| Description | A potent, selective, and orally bioavailable inhibitor of interleukin-1 receptor-associate kinase-4 (IRAK4) with IC50 of 2.8 nM, 217- and 892-fold selectivity over IRAK-1 and TAK1, respectively; inhibits IL-1 induced activation of NF-kB in primary human monocytes with IC50 of 0.3 uM, possesses excellent selectivity and pharmacokinetic properties. |
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| References | References 1. Wang Z, et al. Bioorg Med Chem Lett. 2015 Dec 1;25(23):5546-50. View Related Products by Target IRAK |
| Molecular Formula | C27H25F3N4O |
|---|---|
| Molecular Weight | 478.519 |
| InChIKey | CLRGCYMGDBZQTB-UHFFFAOYSA-N |
| SMILES | O=C(Nc1nc2cc(CN3CCCCC3)ccc2n1-c1ccccc1)c1cccc(C(F)(F)F)c1 |