509093-72-5
509093-72-5 structure
- Name: IRAK4-IN-16
- Chemical Name: IRAK4-IN-16
- CAS Number: 509093-72-5
- Molecular Formula: C27H25F3N4O
- Molecular Weight: 478.519
- Create Date: 2020-01-20 17:48:56
- Modify Date: 2024-01-31 21:09:13
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A potent, selective, and orally bioavailable inhibitor of interleukin-1 receptor-associate kinase-4 (IRAK4) with IC50 of 2.8 nM, 217- and 892-fold selectivity over IRAK-1 and TAK1, respectively; inhibits IL-1 induced activation of NF-kB in primary human monocytes with IC50 of 0.3 uM, possesses excellent selectivity and pharmacokinetic properties.
| Name | IRAK4-IN-16 |
|---|
| Description | A potent, selective, and orally bioavailable inhibitor of interleukin-1 receptor-associate kinase-4 (IRAK4) with IC50 of 2.8 nM, 217- and 892-fold selectivity over IRAK-1 and TAK1, respectively; inhibits IL-1 induced activation of NF-kB in primary human monocytes with IC50 of 0.3 uM, possesses excellent selectivity and pharmacokinetic properties. |
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| References | References 1. Wang Z, et al. Bioorg Med Chem Lett. 2015 Dec 1;25(23):5546-50. View Related Products by Target IRAK |
| Molecular Formula | C27H25F3N4O |
|---|---|
| Molecular Weight | 478.519 |