Tiratricol
Tiratricol structure
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Common Name | Tiratricol | ||
|---|---|---|---|---|
| CAS Number | 51-24-1 | Molecular Weight | 621.932 | |
| Density | 2.5±0.1 g/cm3 | Boiling Point | 531.6±50.0 °C at 760 mmHg | |
| Molecular Formula | C14H9I3O4 | Melting Point | 181.5ºC | |
| MSDS | Chinese USA | Flash Point | 275.3±30.1 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of TiratricolTiratricol is a thyroid hormone analog with hepatic, has been used to suppress pituitary TSH secretion, with attenuation of extrapituitary thyromimetic effects. |
Summary: Tiratricol, with the Chinese name of Tiratricol, has a CAS number of 51-24-1, molecular formula of C14H9I3O4, and a molecular weight of 621.932. This compound is a thyroid hormone analogue used to inhibit the secretion of pituitary thyroid-stimulating hormone. For research-use only, not for medical or clinical usage.
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | 2-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]acetic acid |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Tiratricol is a thyroid hormone analog with hepatic, has been used to suppress pituitary TSH secretion, with attenuation of extrapituitary thyromimetic effects. |
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| Related Catalog |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 2.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 531.6±50.0 °C at 760 mmHg |
| Melting Point | 181.5ºC |
| Molecular Formula | C14H9I3O4 |
| Molecular Weight | 621.932 |
| Flash Point | 275.3±30.1 °C |
| Exact Mass | 621.763489 |
| PSA | 66.76000 |
| LogP | 5.47 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.767 |
| InChIKey | UOWZUVNAGUAEQC-UHFFFAOYSA-N |
| SMILES | O=C(O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1 |
| Storage condition | -20°C |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H312-H332 |
| Precautionary Statements | P280 |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | R20/21/22 |
| Safety Phrases | 36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2918990090 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
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Tiratricol CAS#:51-24-1 |
| Literature: Wilkinson Biochemical Journal, 1956 , vol. 63, p. 601,603 Full Text Show Details Pitt-Rivers Lancet, 1953 , vol. 265, p. 234 |
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Tiratricol CAS#:51-24-1 |
| Literature: Wilkinson Biochemical Journal, 1956 , vol. 63, p. 601,603 |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 2 | |
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| DownStream 0 | |
This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2918990090 |
|---|---|
| Summary | 2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
This table lists relevant public references with title, journal and publication metadata for this compound.
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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Chem. Res. Toxicol. 23 , 171-83, (2010) Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental... |
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A surface on the androgen receptor that allosterically regulates coactivator binding.
Proc. Natl. Acad. Sci. U. S. A. 104 , 16074-9, (2007) Current approaches to inhibit nuclear receptor (NR) activity target the hormone binding pocket but face limitations. We have proposed that inhibitors, which bind to nuclear receptor surfaces that medi... |
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Targeting the binding function 3 (BF3) site of the human androgen receptor through virtual screening.
J. Med. Chem. 54 , 8563-73, (2011) The androgen receptor (AR) is the best studied drug target for the treatment of prostate cancer. While there are a number of drugs that target the AR, they all work through the same mechanism of actio... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| triiodothyroacetic acid |
| Tiratricol,3,3',5-triiodothyroacetic acid |
| 3,5,3'-triiodothyroacetic acid |
| 3,3',5-TRIIODOTHYROACETIC ACID |
| 3,3',5-Triiodo-4-(4-hydroxyphenoxy)phenylacetic Acid |
| Triac |
| 3,5-Diiodo-4-(3-iodo-4-hydroxyphenoxy)phenylacetic Acid |
| [4-(4-Hydroxy-3-iodophenoxy)-3,5-diiodophenyl]acetic acid |
| Tiratricol |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the CAS number of 2-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]acetic acid? |
| A: CAS number of 2-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]acetic acid is 51-24-1. |
| Q: What is the InChIKey of 2-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]acetic acid? |
| A: InChIKey of 2-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]acetic acid is UOWZUVNAGUAEQC-UHFFFAOYSA-N. |
| Q: What is the safety information for 2-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]acetic acid? |
| A: Safety information for 2-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]acetic acid: 36. |
| Q: What is the polar surface area (PSA) of 2-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]acetic acid? |
| A: Polar surface area (PSA) of 2-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]acetic acid is 66.76000. |
| Q: What is the boiling point of 2-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]acetic acid? |
| A: Boiling point of 2-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]acetic acid is 531.6±50.0 °C at 760 mmHg. |
| Q: What are the upstream materials of 2-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]acetic acid? |
| A: Related upstream materials(CAS) of 2-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]acetic acid: 1155-40-4;85828-82-6. |
| Q: What is the SMILES notation of 2-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]acetic acid? |
| A: SMILES notation of 2-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]acetic acid is O=C(O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1. |
| Q: What is the molecular weight of 2-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]acetic acid? |
| A: Molecular weight of 2-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]acetic acid is 621.932. |
| Q: What are the storage conditions for 2-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]acetic acid? |
| A: Storage conditions for 2-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]acetic acid: -20°C. |
| Q: What English synonyms does 2-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]acetic acid have? |
| A: English synonyms of 2-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]acetic acid: triiodothyroacetic acid, Tiratricol,3,3',5-triiodothyroacetic acid, 3,5,3'-triiodothyroacetic acid, 3,3',5-TRIIODOTHYROACETIC ACID, 3,3',5-Triiodo-4-(4-hydroxyphenoxy)phenylacetic Acid, Triac, 3,5-Diiodo-4-(3-iodo-4-hydroxyphenoxy)phenylacetic Acid, [4-(4-Hydroxy-3-iodophenoxy)-3,5-diiodophenyl]acetic acid, Tiratricol. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |