Pifithrin-β
Modify Date: 2026-07-08 01:05:13
Pifithrin-β structure
|
Common Name | Pifithrin-β | ||
|---|---|---|---|---|
| CAS Number | 60477-34-1 | Molecular Weight | 268.37700 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H16N2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Pifithrin-βPifithrin-β is a potent p53 inhibitor with an IC50 of 23 μM. |
| Name | 2-(4-methylphenyl)-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]benzothiazole |
|---|---|
| Synonym | More Synonyms |
| Description | Pifithrin-β is a potent p53 inhibitor with an IC50 of 23 μM. |
|---|---|
| Related Catalog | |
| Target |
IC50: 23 μM (p53)[1] |
| In Vitro | Pifithrin-α, an inhibitor of the p53 protein, is regarded as a lead compound for cancer and neurodegenerative disease therapy. Pifithrin-α is very unstable in culture medium and rapidly converts to its condensation product pifithrin-β, the N-acetyl derivative[2]. After 24 h, the viability assay shows that the pretreatments with 1 and 10 μM pifithrin-β exerts neuroprotective effects[3]. |
| References |
| Molecular Formula | C16H16N2S |
|---|---|
| Molecular Weight | 268.37700 |
| Exact Mass | 268.10300 |
| PSA | 45.54000 |
| LogP | 4.25000 |
| InChIKey | IMUKUMUNZJILCG-UHFFFAOYSA-N |
| SMILES | Cc1ccc(-c2cn3c4c(sc3n2)CCCC4)cc1 |
| Storage condition | 2-8℃ |
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| Pifithrin-Beta |
| UNII-45I8QO7K37 |
| Pifithrin-β |