Pifithrin-β

Modify Date: 2024-01-01 19:40:24

Pifithrin-β structure	Common Name	Pifithrin-β
	CAS Number	60477-34-1	Molecular Weight	268.37700
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₆H₁₆N₂S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Pifithrin-β

Pifithrin-β is a potent p53 inhibitor with an IC50 of 23 μM.

Name	2-(4-methylphenyl)-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]benzothiazole
Synonym	More Synonyms

Description	Pifithrin-β is a potent p53 inhibitor with an IC50 of 23 μM.
Related Catalog	Signaling Pathways >> Apoptosis >> MDM-2/p53 Research Areas >> Cancer
Target	IC50: 23 μM (p53)[1]
In Vitro	Pifithrin-α, an inhibitor of the p53 protein, is regarded as a lead compound for cancer and neurodegenerative disease therapy. Pifithrin-α is very unstable in culture medium and rapidly converts to its condensation product pifithrin-β, the N-acetyl derivative[2]. After 24 h, the viability assay shows that the pretreatments with 1 and 10 μM pifithrin-β exerts neuroprotective effects[3].
References	[1]. Christodoulou MS, et al. Synthesis and biological evaluation of imidazolo[2,1-b]benzothiazole derivatives, as potential p53 inhibitors. Bioorg Med Chem. 2011 Mar 1;19(5):1649-57. [2]. Fernández-Cruz ML, et al. Biological and chemical studies on aryl hydrocarbon receptor induction by the p53 inhibitor pifithrin-α and its condensation product pifithrin-β. Life Sci. 2011 Apr 25;88(17-18):774-83. [3]. Da Pozzo E, et al. p53 functional inhibitors behaving like pifithrin-β counteract the Alzheimer peptide non-β-amyloid component effects in human SH-SY5Y cells. ACS Chem Neurosci. 2014 May 21;5(5):390-9.

Molecular Formula	C₁₆H₁₆N₂S
Molecular Weight	268.37700
Exact Mass	268.10300
PSA	45.54000
LogP	4.25000
Storage condition	2-8℃

Pifithrin-Beta

UNII-45I8QO7K37

Pifithrin-β

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: CYCLIC-PIFITHRIN-ALPHA
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Price: $66/5mg

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