Naphazoline nitrate
Naphazoline nitrate structure
|
Common Name | Naphazoline nitrate | ||
|---|---|---|---|---|
| CAS Number | 5144-52-5 | Molecular Weight | 273.287 | |
| Density | N/A | Boiling Point | 440.5ºC at 760mmHg | |
| Molecular Formula | C14H15N3O3 | Melting Point | 167-170 °C | |
| MSDS | Chinese USA | Flash Point | 220.2ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of Naphazoline nitrateNaphazoline (Naphthazoline) nitrate is an α-adrenergic receptor agonist. Naphazoline nitrate reduces vascular hyperpermeability and promotes vasoconstriction. Naphazoline nitrate reduces the levels of inflammatory factors (TNF-α, IL-1β and IL-6), cytokines (IFN-γ and IL-4), IgE, GMCSF, and NGF。Naphazoline nitrate can be used for non-bacterial conjunctivitis research[1][2]. |
Summary: Naphazoline nitrate (Chinese name: 硝酸萘甲唑啉, CAS number: 5144-52-5, molecular formula: C14H15N3O3, molecular weight: 273.287) is a white solid with a melting point of 167-170°C and is used for treating symptoms such as the common cold, rhinitis, and nasal congestion. For research-use only, not for medical or clinical usage.
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | Naphazoline nitrate |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Naphazoline (Naphthazoline) nitrate is an α-adrenergic receptor agonist. Naphazoline nitrate reduces vascular hyperpermeability and promotes vasoconstriction. Naphazoline nitrate reduces the levels of inflammatory factors (TNF-α, IL-1β and IL-6), cytokines (IFN-γ and IL-4), IgE, GMCSF, and NGF。Naphazoline nitrate can be used for non-bacterial conjunctivitis research[1][2]. |
|---|---|
| Related Catalog | |
| Target |
TNF-α IL-1β IL-6 IL-4 |
| In Vivo | Naphazoline nitrate (0.2 mg/kg, 10 µl per eye; IP, once) reduces histamine or antigen-induced conjunctival vascular hyperpermeability in mice, and reduces conjunctivitis in mice via effects on inflammation, NGF and VEGF[1]. Animal Model: Female wild-type BALB/c mice (4-5 weeks, 18 ± 2 g, n=8/group, allergic conjunctivitis mouse model established using histamine or an antigen (ovalbumin))[1] Dosage: 0.2 mg/mL, 10 µl per eye Administration: Intraperitoneal injection (IP), once Result: Significantly suppressed conjunctival dye leakage in mice with histamine or antigen‑induced conjunctival vascular hyperpermeability. Reduced inflammatory reactions and the levels of IL-1β, IL-6, IFN-γ, and IL-4. Reduced the levels of IgE, GMCSF, NGF and VEGF in antigen-induced conjunctival vascular hyperpermeability mice. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Boiling Point | 440.5ºC at 760mmHg |
|---|---|
| Melting Point | 167-170 °C |
| Molecular Formula | C14H15N3O3 |
| Molecular Weight | 273.287 |
| Flash Point | 220.2ºC |
| Exact Mass | 273.111328 |
| PSA | 90.44000 |
| LogP | 2.32390 |
| InChIKey | ZAHXYMFVNNUHCP-UHFFFAOYSA-N |
| SMILES | O=[N+]([O-])O.c1ccc2c(CC3=NCCN3)cccc2c1 |
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Precautionary Statements | P301 + P312 + P330 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn:Harmful; |
| Risk Phrases | R22 |
| Safety Phrases | S22-S36/37 |
| RIDADR | 3249 |
| WGK Germany | 3 |
| RTECS | NJ4376000 |
| Packaging Group | III |
| Hazard Class | 6.1(b) |
| HS Code | 2933290090 |
This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2934999090 |
|---|---|
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| 2-(1-Naphthylmethyl)-2-imidazoline nitrate |
| 2-(1-Naphthylmethyl)imidazoline nitrate,Naphazolini nitras |
| naphtyzin |
| EINECS 225-915-4 |
| 1H-Imidazole, 4,5-dihydro-2-(1-naphthalenylmethyl)-, nitrate (1:1) |
| MFCD00014316 |
| 2-imidazoline, 2-(1-naphthylmethyl)-, mononitrate |
| 2-(1-Naphthylmethyl)imidazoline nitrate |
| NAPHAZOLINI NITRAS |
| 2-(1-Naphthylmethyl)-4,5-dihydro-1H-imidazole nitrate (1:1) |
| privinenitrate |
| Privina |
| Naphazoline nitrate |
| naphthisen |
| naftizin |
| 1H-Imidazole, 4,5-dihydro-2-(1-naphthalenylmethyl)-, mononitrate (9CI) |
| rinazin |
| 2-(naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole nitrate (1:1) |
| naphthizen |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the polar surface area (PSA) of Naphazoline nitrate? |
| A: Polar surface area (PSA) of Naphazoline nitrate is 90.44000. |
| Q: What is the English name of Naphazoline nitrate? |
| A: The English name of Naphazoline nitrate is Naphazoline nitrate. |
| Q: What is the molecular weight of Naphazoline nitrate? |
| A: Molecular weight of Naphazoline nitrate is 273.287. |
| Q: What are the uses of Naphazoline nitrate? |
| A: Main uses of Naphazoline nitrate: Naphazoline (Naphthazoline) nitrate is an α-adrenergic receptor agonist. Naphazoline nitrate reduces vascular hyperpermeability and promotes vasoconstriction. Naphazoline nitrate reduces the levels of inflammatory factors (TNF-α, IL-1β and IL-6), cytokines (IFN-γ and IL-4), IgE, GMCSF, and NGF。Naphazoline nitrate can be used for non-bacterial conjunctivitis research[1][2]. |
| Q: What is the LogP of Naphazoline nitrate? |
| A: LogP of Naphazoline nitrate is 2.32390. |
| Q: What is the safety information for Naphazoline nitrate? |
| A: Safety information for Naphazoline nitrate: S22-S36/37. |
| Q: What is the boiling point of Naphazoline nitrate? |
| A: Boiling point of Naphazoline nitrate is 440.5ºC at 760mmHg. |
| Q: What is the SMILES notation of Naphazoline nitrate? |
| A: SMILES notation of Naphazoline nitrate is O=[N+]([O-])O.c1ccc2c(CC3=NCCN3)cccc2c1. |
| Q: What is the melting point of Naphazoline nitrate? |
| A: Melting point of Naphazoline nitrate is 167-170 °C. |
| Q: What is the CAS number of Naphazoline nitrate? |
| A: CAS number of Naphazoline nitrate is 5144-52-5. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |