1,5-Isoquinolinediol

Modify Date: 2024-01-02 20:49:07

1,5-Isoquinolinediol Structure
1,5-Isoquinolinediol structure
Common Name 1,5-Isoquinolinediol
CAS Number 5154-02-9 Molecular Weight 161.157
Density 1.4±0.1 g/cm3 Boiling Point 501.1±30.0 °C at 760 mmHg
Molecular Formula C9H7NO2 Melting Point 270-275 °C
MSDS Chinese USA Flash Point 256.8±24.6 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of 1,5-Isoquinolinediol


1,5-Isoquinolinediol is a potent PARP inhibitor, with an IC50 of 0.18-0.37 µM. 1,5-Isoquinolinediol attenuates diabetes-induced NADPH oxidase-derived oxidative stress in retina[1][2].

 Names

Name isoquinoline-1,5-diol
Synonym More Synonyms

 1,5-Isoquinolinediol Biological Activity

Description 1,5-Isoquinolinediol is a potent PARP inhibitor, with an IC50 of 0.18-0.37 µM. 1,5-Isoquinolinediol attenuates diabetes-induced NADPH oxidase-derived oxidative stress in retina[1][2].
Related Catalog
Target

PARP:0.18-0.37 μM (IC50)

In Vitro 1,5-isoquinolinediol leads to an increase up to 8-fold in the absolute frequency of gene targeting in the correction of the mutation at the stable integrated HSV tk gene[1]. 1,5-Isoquinolinediol is a potent PARP antagonist and decreases cleaved PARP in diabetic retina.1,5-Isoquinolinediol (500 μM H2O2; 24 hours) attenuates H2O2-induced upregulation of cleaved PARP-1 expression in retinal Muller cells. 1,5-Isoquinolinediol attenuates diabetes-induced upregulation of retinal nitrated protein expression. 1,5-Isoquinolinediol attenuates diabetes-induced activation of NADPH oxidase in the retina[2].
References

[1]. Crockett SL, et al. Role of dopamine and selective dopamine receptor agonists on mouse ductus arteriosus tone and responsiveness. Pediatr Res. 2019 Dec 9.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 501.1±30.0 °C at 760 mmHg
Melting Point 270-275 °C
Molecular Formula C9H7NO2
Molecular Weight 161.157
Flash Point 256.8±24.6 °C
Exact Mass 161.047684
PSA 53.35000
LogP -0.17
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.743
Storage condition 2-8°C
Water Solubility DMSO: >36 mg/mL

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S37/39
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2933499090

 Customs

HS Code 2933499090
Summary 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles23

More Articles
Inhibitors of poly (ADP-ribose) synthetase protect rat cardiomyocytes against oxidant stress.

Cardiovasc. Res. 41(1) , 126-34, (1999)

Inhibitors of poly (ADP-ribose) synthetase (PARS) activity reduce the infarct size caused by regional myocardial ischaemia and reperfusion in the rabbit and rat in vivo. The mechanism of action of the...

Prevention of the degeneration of human dopaminergic neurons in an astrocyte co-culture system allowing endogenous drug metabolism.

Br. J. Pharmacol. 172 , 4119-32, (2015)

Few neuropharmacological model systems use human neurons. Moreover, available test systems rarely reflect functional roles of co-cultured glial cells. There is no human in vitro counterpart of the wid...

Modulation of the poly (ADP-ribose) polymerase inhibitor response and DNA recombination in breast cancer cells by drugs affecting endogenous wild-type p53.

Carcinogenesis 35(10) , 2273-82, (2014)

Synthetic lethal interactions between poly (ADP-ribose) polymerase (PARP) and homologous recombination (HR) repair pathways have been exploited for the development of novel mono- and combination cance...

 Synonyms

isoquinoline-1,5-diol
5-Hydroxyisocarbostyril
5-Hydroxy-1(2H)-isoquinolinone
5-Hydroxyisoquinoline-1(2H)-one
1(2H)-Isoquinolinone, 5-hydroxy-
1,5-Dihydroxyisoquinoline 5-Hydroxy-1(2H)-isoquinolinone DiQ
5-hydroxy-2H-isoquinolin-1-one
MFCD00006900
5-Hydroxyisoquinolin-1(2H)-one
1,5-Isoquinolinediol