Spironolactone
Modify Date: 2024-01-02 17:40:31
Spironolactone structure
|
Common Name | Spironolactone | ||
|---|---|---|---|---|
| CAS Number | 52-01-7 | Molecular Weight | 416.573 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 597.0±50.0 °C at 760 mmHg | |
| Molecular Formula | C24H32O4S | Melting Point | 207-208 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 302.3±18.1 °C | |
| Symbol |
GHS08 |
Signal Word | Danger | |
Use of SpironolactoneSpironolactone is a potent antagonist of the androgen receptor. Target: Androgen ReceptorSpironolactone is a potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. 5% topical spironolactone cream acts as an antiandrogen in human sebaceous glands, competing with DHT receptors and producing a decrease of labelled DHT. At the concentrations used the effect has been only local. No side-effects were recorded during both studies [1]. Patients who received spironolactone had a significant improvement in the symptoms of heart failure, as assessed on the basis of the New York Heart Association functional class (P<0.001). Gynecomastia or breast pain was reported in 10 percent of men who were treated with spironolactone, as compared with 1 percent of men in the placebo group (P<0.001). The incidence of serious hyperkalemia was minimal in both groups of patients [2]. |
| Name | Spironolactone |
|---|---|
| Synonym | More Synonyms |
| Description | Spironolactone is a potent antagonist of the androgen receptor. Target: Androgen ReceptorSpironolactone is a potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. 5% topical spironolactone cream acts as an antiandrogen in human sebaceous glands, competing with DHT receptors and producing a decrease of labelled DHT. At the concentrations used the effect has been only local. No side-effects were recorded during both studies [1]. Patients who received spironolactone had a significant improvement in the symptoms of heart failure, as assessed on the basis of the New York Heart Association functional class (P<0.001). Gynecomastia or breast pain was reported in 10 percent of men who were treated with spironolactone, as compared with 1 percent of men in the placebo group (P<0.001). The incidence of serious hyperkalemia was minimal in both groups of patients [2]. |
|---|---|
| Related Catalog | |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 597.0±50.0 °C at 760 mmHg |
| Melting Point | 207-208 °C(lit.) |
| Molecular Formula | C24H32O4S |
| Molecular Weight | 416.573 |
| Flash Point | 302.3±18.1 °C |
| Exact Mass | 416.202118 |
| PSA | 85.74000 |
| LogP | 3.12 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.586 |
| Water Solubility | practically insoluble |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| Symbol |
GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H360 |
| Precautionary Statements | P201-P280-P308 + P313 |
| Personal Protective Equipment | Eyeshields;Gloves;type P2 (EN 143) respirator cartridges |
| Hazard Codes | T:Toxic |
| Risk Phrases | R40;R60 |
| Safety Phrases | 53-22-36/37/39-45-36-26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | TU4725000 |
| HS Code | 2937290090 |
![5'-hydroxyspiro[pregnane-17,2'-tetrahydrofuran]-5-en-3-one structure](https://image.chemsrc.com/caspic/151/121936-43-4.png)
CAS#:38753-77-4
CAS#:79327-11-0| HS Code | 2937290090 |
|---|
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Evidence for aldosterone-dependent growth of renal cell carcinoma.
Int. J. Exp. Pathol. 95(4) , 244-50, (2014) The aim if this study was to investigate the hypothesis that K-RAS 4A is upregulated in a mineralocorticoid-dependent manner in renal cell carcinoma and that this supports the proliferation and surviv... |
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Mineralocorticoid receptor blockade improves coronary microvascular function in individuals with type 2 diabetes.
Diabetes 64(1) , 236-42, (2015) Reduced coronary flow reserve (CFR), an indicator of coronary microvascular dysfunction, is seen in type 2 diabetes mellitus (T2DM) and predicts cardiac mortality. Since aldosterone plays a key role i... |
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Patient with purulent pericarditis: a case doomed to fail?
Kardiol. Pol. 71(2) , 176-8, (2013) Exudative pericarditis, and in particular a purulent type, is a rare condition which requires emergency medical intervention. In our paper we present a case report concerning a patient with purulent p... |
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- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Spironolactone
- Price: ￥178.0/1g
- Purity: 98.0%
- Delivery: 2 Day
- Contact: Liu jia
- Email: 2130147988@qq.com
- DC Chemicals Limited
- China
- Product Name: SC9420
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
- Henan Tianfu Chemical Co., Ltd.
- China
- Product Name: Spironolactone
- Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
- Purity: 99.0%
- Delivery: Inquiry
- Contact: Anson
- Email: info@tianfuchem.com
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