Spironolactone
Modify Date: 2026-07-04 07:41:35
Spironolactone structure
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Common Name | Spironolactone | ||
|---|---|---|---|---|
| CAS Number | 52-01-7 | Molecular Weight | 416.573 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 597.0±50.0 °C at 760 mmHg | |
| Molecular Formula | C24H32O4S | Melting Point | 207-208 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 302.3±18.1 °C | |
| Symbol |
GHS08 |
Signal Word | Danger | |
Use of SpironolactoneSpironolactone is a potent antagonist of the androgen receptor. Target: Androgen ReceptorSpironolactone is a potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. 5% topical spironolactone cream acts as an antiandrogen in human sebaceous glands, competing with DHT receptors and producing a decrease of labelled DHT. At the concentrations used the effect has been only local. No side-effects were recorded during both studies [1]. Patients who received spironolactone had a significant improvement in the symptoms of heart failure, as assessed on the basis of the New York Heart Association functional class (P<0.001). Gynecomastia or breast pain was reported in 10 percent of men who were treated with spironolactone, as compared with 1 percent of men in the placebo group (P<0.001). The incidence of serious hyperkalemia was minimal in both groups of patients [2]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | Spironolactone |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Spironolactone is a potent antagonist of the androgen receptor. Target: Androgen ReceptorSpironolactone is a potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. 5% topical spironolactone cream acts as an antiandrogen in human sebaceous glands, competing with DHT receptors and producing a decrease of labelled DHT. At the concentrations used the effect has been only local. No side-effects were recorded during both studies [1]. Patients who received spironolactone had a significant improvement in the symptoms of heart failure, as assessed on the basis of the New York Heart Association functional class (P<0.001). Gynecomastia or breast pain was reported in 10 percent of men who were treated with spironolactone, as compared with 1 percent of men in the placebo group (P<0.001). The incidence of serious hyperkalemia was minimal in both groups of patients [2]. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 597.0±50.0 °C at 760 mmHg |
| Melting Point | 207-208 °C(lit.) |
| Molecular Formula | C24H32O4S |
| Molecular Weight | 416.573 |
| Flash Point | 302.3±18.1 °C |
| Exact Mass | 416.202118 |
| PSA | 85.74000 |
| LogP | 3.12 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.586 |
| InChIKey | LXMSZDCAJNLERA-ZHYRCANASA-N |
| SMILES | CC(=O)SC1CC2=CC(=O)CCC2(C)C2CCC3(C)C(CCC34CCC(=O)O4)C12 |
| Water Solubility | practically insoluble |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H360 |
| Precautionary Statements | P201-P280-P308 + P313 |
| Personal Protective Equipment | Eyeshields;Gloves;type P2 (EN 143) respirator cartridges |
| Hazard Codes | T:Toxic |
| Risk Phrases | R40;R60 |
| Safety Phrases | 53-22-36/37/39-45-36-26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | TU4725000 |
| HS Code | 2937290090 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
![5'-hydroxyspiro[pregnane-17,2'-tetrahydrofuran]-5-en-3-one structure](https://image.chemsrc.com/caspic/151/121936-43-4.png)
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 5 | |
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| DownStream 3 | |
CAS#:38753-77-4
CAS#:79327-11-0This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2937290090 |
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This table lists relevant public references with title, journal and publication metadata for this compound.
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Evidence for aldosterone-dependent growth of renal cell carcinoma.
Int. J. Exp. Pathol. 95(4) , 244-50, (2014) The aim if this study was to investigate the hypothesis that K-RAS 4A is upregulated in a mineralocorticoid-dependent manner in renal cell carcinoma and that this supports the proliferation and surviv... |
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Mineralocorticoid receptor blockade improves coronary microvascular function in individuals with type 2 diabetes.
Diabetes 64(1) , 236-42, (2015) Reduced coronary flow reserve (CFR), an indicator of coronary microvascular dysfunction, is seen in type 2 diabetes mellitus (T2DM) and predicts cardiac mortality. Since aldosterone plays a key role i... |
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Patient with purulent pericarditis: a case doomed to fail?
Kardiol. Pol. 71(2) , 176-8, (2013) Exudative pericarditis, and in particular a purulent type, is a rare condition which requires emergency medical intervention. In our paper we present a case report concerning a patient with purulent p... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| Spirolakton |
| Aldopur |
| Osiren |
| Sagisal |
| Laractone |
| Suracton |
| Diatensec |
| MFCD00082250 |
| spironolactone |
| Deverol |
| S-[(7R,8R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxospiro[2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-17,2'-oxolane]-7-yl] ethanethioate |
| Supra-puren |
| Aquareduct |
| Lacalmin |
| Ethanethioic acid, S-[(7R,8R,9S,10R,13S,14S,17R)-1,2,3,4',5',6,7,8,9,10,11,12,13,14,15,16-hexadecahydro-10,13-dimethyl-3,5'-dioxospiro[17H-cyclopenta[a]phenanthrene-17,2'(3'H)-furan]-7-yl] ester |
| Nefurofan |
| Aldace |
| Duraspiron |
| (7a,17a)-7-(Acetylthio)-17-hydroxy-3-oxopregn-4-ene-21-carboxylic acid g-lactone |
| EINECS 200-133-6 |
| Osyrol |
| Lacdene |
| SPIRONOLACTONE A |
| Aldactone |
| Spiroderm |
| Spiretic |
| 17-Hydroxy-7a-mercapto-3-oxo-17a-pregn-4-ene-21-carboxylic Acid g-Lactone Acetate |
| S-[(7R,8R,9S,10R,13S,14S,17R)-10,13-Dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,9,10,11,12,13,14,15,16-hexadecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-yl] ethanethioate |
| 3-(3-Oxo-7a-acetylthio-17b-hydroxy-4-androsten-17a-yl)propionic Acid g-Lactone |
| Altex |
| Spirolone |
| Almatol |
| Sincomen |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the InChIKey of Spironolactone? |
| A: InChIKey of Spironolactone is LXMSZDCAJNLERA-ZHYRCANASA-N. |
| Q: What is the molecular weight of Spironolactone? |
| A: Molecular weight of Spironolactone is 416.573. |
| Q: What are the downstream products of Spironolactone? |
| A: Related downstream products(CAS) of Spironolactone: 38753-77-4;976-71-6;79327-11-0. |
| Q: What is the LogP of Spironolactone? |
| A: LogP of Spironolactone is 3.12. |
| Q: What are the upstream materials of Spironolactone? |
| A: Related upstream materials(CAS) of Spironolactone: 976-71-6;507-09-5;976-70-5;434-03-7;121936-43-4. |
| Q: What is the boiling point of Spironolactone? |
| A: Boiling point of Spironolactone is 597.0±50.0 °C at 760 mmHg. |
| Q: What is the polar surface area (PSA) of Spironolactone? |
| A: Polar surface area (PSA) of Spironolactone is 85.74000. |
| Q: What is the molecular formula of Spironolactone? |
| A: Molecular formula of Spironolactone is C24H32O4S. |
| Q: What is the CAS number of Spironolactone? |
| A: CAS number of Spironolactone is 52-01-7. |
| Q: What is the melting point of Spironolactone? |
| A: Melting point of Spironolactone is 207-208 °C(lit.). |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Henan Tianfu Chemical Co., Ltd. |