aldosterone
aldosterone structure
|
Common Name | aldosterone | ||
|---|---|---|---|---|
| CAS Number | 52-39-1 | Molecular Weight | 360.444 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 568.1±50.0 °C at 760 mmHg | |
| Molecular Formula | C21H28O5 | Melting Point | 170-172ºC | |
| MSDS | Chinese USA | Flash Point | 311.4±26.6 °C | |
| Symbol |
GHS02, GHS07 |
Signal Word | Danger | |
Use of aldosteroneAldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by the zona glomerulosa (ZG) of the adrenal cortex. Aldosterone activity is dependent by the binding and activation of the cytoplasmic/nuclear mineralocorticoid receptor (MR) at cellular level[1][2]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | aldosterone |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by the zona glomerulosa (ZG) of the adrenal cortex. Aldosterone activity is dependent by the binding and activation of the cytoplasmic/nuclear mineralocorticoid receptor (MR) at cellular level[1][2]. |
|---|---|
| Related Catalog | |
| Target |
Human Endogenous Metabolite |
| In Vitro | Aldosterone (1-1000 nM; 24 hours) inhibits interleukin-1β-stimulated nitrite production by vascular smooth muscle cells in a dose-dependent manner[3]. |
| In Vivo | Aldosterone (1 mg/Kg+1% NaCl; i.h.; once daily for 3 weeks) significantly increases systolic blood pressure (SBP), diastolic blood pressure (DBP), left ventricular systolic pressure (LVSP) and left ventricular end-diastolic pressure (LVEDP)[4]. Aldosterone (0.72 mg/kg/day; 14 days) causes a small increase ( 14 mmHg) in blood pressure in male mice[5]. Animal Model: Forty male Wistar rats[4] Dosage: 1 mg/Kg (+1% NaCl) Administration: i.h.; once daily for 3 weeks Result: Systolic blood pressure (SBP), diastolic blood pressure (DBP), left ventricular systolic pressure (LVSP) and left ventricular end-diastolic pressure (LVEDP) were significantly higher in aldosterone-salt-treated animals. |
| References |
[1]. Nanba K, et al. Aging and Adrenal Aldosterone Production. Hypertension. 2018 Feb;71(2):218-223. |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 568.1±50.0 °C at 760 mmHg |
| Melting Point | 170-172ºC |
| Molecular Formula | C21H28O5 |
| Molecular Weight | 360.444 |
| Flash Point | 311.4±26.6 °C |
| Exact Mass | 360.193665 |
| PSA | 91.67000 |
| LogP | 0.73 |
| Vapour Pressure | 0.0±3.5 mmHg at 25°C |
| Index of Refraction | 1.586 |
| InChIKey | PQSUYGKTWSAVDQ-ZVIOFETBSA-N |
| SMILES | CC12CCC(=O)C=C1CCC1C2C(O)CC2(C=O)C(C(=O)CO)CCC12 |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
|
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS02, GHS07 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H225-H302 + H312 + H332-H319 |
| Precautionary Statements | P210-P280-P305 + P351 + P338 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
| Hazard Codes | Xi |
| Risk Phrases | R36/37/38 |
| Safety Phrases | 22-24/25-36-26 |
| RIDADR | UN 1648 3 / PGII |
| WGK Germany | 3 |
| RTECS | TU4523000 |
| HS Code | 29372900 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
|
~%
aldosterone CAS#:52-39-1 |
| Literature: Helvetica Chimica Acta, , vol. 38, p. 1423,1436 Experientia, , vol. 12, p. 50 |
|
~%
aldosterone CAS#:52-39-1 |
| Literature: Helvetica Chimica Acta, , vol. 38, p. 1423,1436 |
|
~%
aldosterone CAS#:52-39-1 |
| Literature: Helvetica Chimica Acta, , vol. 38, p. 1423,1436 |
|
~%
aldosterone CAS#:52-39-1 |
| Literature: Helvetica Chimica Acta, , vol. 38, p. 1423,1436 |
|
~%
aldosterone CAS#:52-39-1 |
| Literature: Helvetica Chimica Acta, , vol. 38, p. 1423,1436 |
|
~%
aldosterone CAS#:52-39-1
Learn More
|
| Literature: Steroids, , vol. 36, # 5 p. 601 - 609 |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 6 | |
|---|---|
| DownStream 1 | |
CAS#:76959-24-5This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 29372900 |
|---|
This table lists relevant public references with title, journal and publication metadata for this compound.
|
Cistrome of the aldosterone-activated mineralocorticoid receptor in human renal cells.
FASEB J. 29 , 3977-89, (2015) Aldosterone exerts its effects mainly by activating the mineralocorticoid receptor (MR), a transcription factor that regulates gene expression through complex and dynamic interactions with coregulator... |
|
|
Finerenone Impedes Aldosterone-dependent Nuclear Import of the Mineralocorticoid Receptor and Prevents Genomic Recruitment of Steroid Receptor Coactivator-1.
J. Biol. Chem. 290 , 21876-89, (2015) Aldosterone regulates sodium homeostasis by activating the mineralocorticoid receptor (MR), a member of the nuclear receptor superfamily. Hyperaldosteronism leads todeleterious effects on the kidney, ... |
|
|
Sodium homeostasis is preserved in a global 11β-hydroxysteroid dehydrogenase type 1 knockout mouse model.
Exp. Physiol. 100 , 1362-78, (2015) What is the central question of this study? Glucocorticoids act in the kidney to promote salt and water retention. Renal 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1), by increasing local concentr... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
|
Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN
|
|
Name: Thermal Shift Assay. Domain: start/stop: M1-L298
Source: ChEMBL
Target: Cyclin-dependent kinase 2
External Id: CHEMBL5062802
|
|
Name: Displacement of [3H]dexamethasone from Glucocorticoid receptor of rabbit kidney
Source: ChEMBL
Target: Glucocorticoid receptor
External Id: CHEMBL685134
|
|
Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
|
|
Name: TP_TRANSPORTER: inhibition of Ouabain uptake (Ouabain: 100 uM, Aldosterone: 100 uM) i...
Source: ChEMBL
Target: Solute carrier organic anion transporter family member 1A1
External Id: CHEMBL2076388
|
|
Name: TP_TRANSPORTER: transepithelial transport (basal to apical) in MDR1-expressing LLC-PK...
Source: ChEMBL
Target: ATP-dependent translocase ABCB1
External Id: CHEMBL2077335
|
|
Name: Fluorescence-based cell-based primary high throughput screening assay to identify pos...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_PAM_FLUO8_1536_1X%ACT PRUN
|
|
Name: Fluorescence polarization-based biochemical high throughput primary assay to identify...
Source: The Scripps Research Institute Molecular Screening Center
Target: RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens]
External Id: SIAE_INH_FP_1536_1X%INH PRUN
|
|
Name: Thermal Shift Assay. Domain: start/stop: M1-S360
Source: ChEMBL
Target: Mitogen-activated protein kinase 1
External Id: CHEMBL5066868
|
|
Name: Binding affinity to the corticosteroid-binding globulin (CBG) receptor.
Source: ChEMBL
Target: N/A
External Id: CHEMBL665776
|
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| 11β,21-Dihydroxy-3,20-dioxo-pregn-4-en-18-al |
| (11β)-11,21-dihydroxy-3,20-dioxo-Pregn-4-en-18-al |
| Aldocorten |
| Aldocortene |
| (11b)-11,21-dihydroxy-3,20-dioxo-pregn-4-en-18-al |
| 11-β,21-Dihydroxy-3,20-dioxopregn-4-en-18-al |
| Aldocortin |
| MFCD00051136 |
| Aldosterone |
| (11β)-11,21-Dihydroxy-3,20-dioxopregn-4-en-18-al |
| d-Aldosterone |
| 18-Oxocorticosterone |
| (11b)-11,21-Dihydroxy-3,20-dioxopregn-4-en-18-al |
| 18-Formyl-11b,21-dihydroxy-4-pregnene-3,20-dione |
| 11b,21-dihydroxy-3,20-dioxo-pregn-4-en-18-al |
| 11β,21-Dihydroxypregn-4-ene-3,18,20-trione |
| (8S,9S,10R,11S,13R,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10-methyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthrene-13-carbaldehyde |
| Reichstein X |
| Elektrocortin |
| 4-pregnen-11,21-diol-3,20-dione-18-al |
| EINECS 200-139-9 |
| Electrocortin |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the molecular formula of aldosterone? |
| A: Molecular formula of aldosterone is C21H28O5. |
| Q: What is the CAS number of aldosterone? |
| A: CAS number of aldosterone is 52-39-1. |
| Q: What are the downstream products of aldosterone? |
| A: Related downstream products(CAS) of aldosterone: 76959-24-5. |
| Q: What is the English name of aldosterone? |
| A: The English name of aldosterone is aldosterone. |
| Q: What are the upstream materials of aldosterone? |
| A: Related upstream materials(CAS) of aldosterone: 124537-57-1;297-91-6;2507-89-3;3329-80-4;86698-82-0;145-13-1. |
| Q: What is the LogP of aldosterone? |
| A: LogP of aldosterone is 0.73. |
| Q: What is the safety information for aldosterone? |
| A: Safety information for aldosterone: 22-24/25-36-26. |
| Q: What is the molecular weight of aldosterone? |
| A: Molecular weight of aldosterone is 360.444. |
| Q: What is the SMILES notation of aldosterone? |
| A: SMILES notation of aldosterone is CC12CCC(=O)C=C1CCC1C2C(O)CC2(C=O)C(C(=O)CO)CCC12. |
| Q: What is the InChIKey of aldosterone? |
| A: InChIKey of aldosterone is PQSUYGKTWSAVDQ-ZVIOFETBSA-N. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |