bronopol

Modify Date: 2025-08-20 16:43:49

bronopol structure	Common Name	bronopol
	CAS Number	52-51-7	Molecular Weight	199.988
	Density	2.0±0.1 g/cm3	Boiling Point	358.0±42.0 °C at 760 mmHg
	Molecular Formula	C₃H₆BrNO₄	Melting Point	130-133 °C(lit.)
	MSDS	Chinese USA	Flash Point	170.3±27.9 °C
	Symbol	GHS05, GHS07, GHS09	Signal Word	Danger

Use of bronopol

Bronopol is an antimicrobial, with low mammalian toxicity (at in-use levels) and high activity against bacteria (especially the troublesome Gram-negative species).

Name	bronopol
Synonym	More Synonyms

Description	Bronopol is an antimicrobial, with low mammalian toxicity (at in-use levels) and high activity against bacteria (especially the troublesome Gram-negative species).
Related Catalog	Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection

Density	2.0±0.1 g/cm3
Boiling Point	358.0±42.0 °C at 760 mmHg
Melting Point	130-133 °C(lit.)
Molecular Formula	C₃H₆BrNO₄
Molecular Weight	199.988
Flash Point	170.3±27.9 °C
Exact Mass	198.948013
PSA	86.28000
LogP	1.72
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.575
Stability	Stable. Hygroscopic. Incompatible with strong oxidizing agents, strong bases, strong reducing agents, acid chlorides and anhydrides, moisture.
Water Solubility	25 g/100 mL (22 ºC)

bronopol MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TY3385000

CHEMICAL NAME :: 1,3-Propanediol, 2-bromo-2-nitro-

CAS REGISTRY NUMBER :: 52-51-7

BEILSTEIN REFERENCE NO. :: 1705868

LAST UPDATED :: 199701

DATA ITEMS CITED :: 20

MOLECULAR FORMULA :: C3-H6-Br-N-O4

MOLECULAR WEIGHT :: 200.01

WISWESSER LINE NOTATION :: WNXE1Q1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Human

REFERENCE :: JSCCA5 Journal of the Society of Cosmetic Chemists. (Soc. of Cosmetic Chemists, 1995 Broadway, Suite 1701, New York, NY 10023) V.1- 1947- Volume(issue)/page/year: 29,3,1978

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC. Volume(issue)/page/year: 4(4),47,1980

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC. Volume(issue)/page/year: 4(4),47,1980

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: JSCCA5 Journal of the Society of Cosmetic Chemists. (Soc. of Cosmetic Chemists, 1995 Broadway, Suite 1701, New York, NY 10023) V.1- 1947- Volume(issue)/page/year: 29,3,1978 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College Science Pub., 1969 Volume(issue)/page/year: 5,30,1976

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/m3/6H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,103,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86 Volume(issue)/page/year: A542,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 26 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JSCCA5 Journal of the Society of Cosmetic Chemists. (Soc. of Cosmetic Chemists, 1995 Broadway, Suite 1701, New York, NY 10023) V.1- 1947- Volume(issue)/page/year: 29,3,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 170 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Skin and Appendages - hair

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 8,1029,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 37400 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 8,680,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 270 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,103,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4750 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 8,680,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KHFZAN Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967- Volume(issue)/page/year: 11(1),73,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 116 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 8,680,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 48 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 8,680,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College Science Pub., 1969 Volume(issue)/page/year: 5,30,1976 *** REVIEWS *** TOXICOLOGY REVIEW JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 3(3),139,1984 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1235 No. of Facilities: 117 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 5176 (estimated) No. of Female Employees: 4904 (estimated)

Symbol	GHS05, GHS07, GHS09
Signal Word	Danger
Hazard Statements	H302 + H312-H315-H318-H335-H410
Precautionary Statements	P273-P280-P302 + P352 + P312-P305 + P351 + P338 + P310-P501
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xn:Harmful
Risk Phrases	R21/22;R37/38;R41;R50
Safety Phrases	S26-S37/39-S61
RIDADR	UN 3241 4.1/PG 3
WGK Germany	2
RTECS	TY3385000
Packaging Group	III
Hazard Class	4.1
HS Code	2905590030

Formaldehyde

CAS#:50-00-0

nitromethane

CAS#:75-52-5

Tribromonitromethane

CAS#:464-10-8

~74%

bronopol

CAS#:52-51-7

Literature: BROMINE COMPOUNDS LTD. Patent: WO2009/107133 A1, 2009 ; Location in patent: Page/Page column 22-24 ;

2-(Hydroxymethy...

CAS#:126-11-4

bronopol

CAS#:52-51-7

Literature: Trenel; Wilkendorf Chemische Berichte, 1924 , vol. 57, p. 2129

Formaldehyde

CAS#:50-00-0

bronopol

CAS#:52-51-7

Literature: Urbanski et al. Roczniki Chemii, 1957 , vol. 31, p. 93,96 Chem.Abstr., 1957 , p. 14717

Formaldehyde

CAS#:50-00-0

Bromonitromethane

CAS#:563-70-2

bronopol

CAS#:52-51-7

Literature: Maas Chem. Zentralbl., 1899 , vol. 70, # I p. 179 Full Text Show Details Henry Recueil des Travaux Chimiques des Pays-Bas, 1897 , vol. 16, p. 252 Chem. Zentralbl., 1898 , vol. 69, # I p. 192

2-(Hydroxymethy...

CAS#:126-11-4

bronopol

CAS#:52-51-7

Tribromonitromethane

CAS#:464-10-8

Literature: Trenel; Wilkendorf Chemische Berichte, 1924 , vol. 57, p. 2129

Precursor 5
CAS#:50-00-0 Formaldehyde CAS#:75-52-5 nitromethane CAS#:464-10-8 Tribromonitromethane CAS#:126-11-4 2-(Hydroxymethy...
CAS#:563-70-2 Bromonitromethane
DownStream 10
CAS#:464-10-8 Tribromonitromethane CAS#:5437-60-5 Ethanol,2-bromo... CAS#:69094-18-4 2,2-Dibromo-2-n... CAS#:150-60-7 Dibenzyl disulfide
CAS#:1092975-49-9 2,3-bis(hydroxy... CAS#:29609-98-1 2,2-dinitroethanol CAS#:67-56-1 Methanol CAS#:64-18-6 Formic Acid
CAS#:79-14-1 Glycolic acid CAS#:126-11-4 2-(Hydroxymethy...

HS Code	2905590030

Non-fragrance allergens in specific cosmetic products.

Contact Dermatitis 65(5) , 276-85, (2011)

Reports about the nature of the ingredients responsible for allergic contact dermatitis caused by specific cosmetic products are scarce.Between January 2000 and December 2010, the specific cosmetic pr...

Cutaneous delayed-type hypersensitivity in patients with atopic dermatitis: reactivity to topical preservatives.

J. Am. Acad. Dermatol. 70(1) , 102-7, (2014)

Patients with atopic dermatitis (AD) have chronic dry skin to which they frequently apply skin care products containing preservatives, and they are predisposed to developing cutaneous delayed-type hyp...

Patch testing with formaldehyde and formaldehyde-releasers: multicentre study in Spain (2005-2009).

Contact Dermatitis 65(5) , 286-92, (2011)

Formaldehyde and formaldehyde-releasers are common causes of allergic contact dermatitis.To determine the frequency of sensitization to formaldehyde and seven formaldehyde-releasers. To establish and ...

UN 3241

MFCD00007390

UNII-6PU1E16C9W

bronopol

EINECS 200-143-0

2-Bromo-2-nitropropane-1,3-diol (Bronopol)

2-Bromo-2-nitro-1,3-propanediol

b-Bromo-b-nitrotrimethyleneglycol

2-bromo-2-nitropropane-1,3-diol

2-Brom-2-nitropropan-1,3-diol

2-Bromo-2-nitro-1,3-propanediol,BNPD,BNPK

4-01-00-02501 (Beilstein Handbook Reference)

1,3-Propanediol, 2-bromo-2-nitro-

WNXE1Q1Q

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: bronopol
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: bronopol
Price: ￥98.0/25g ￥308.0/100g ￥728.0/500g
Purity: 98.0%
Delivery: Inquiry
Contact: Liu jia
Email: 2130147988@qq.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Bronopol
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Water Treatment-(2-Bromo-2nitropropan-1,3-diol)
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

Zhongshan Xingrui Chemical Co. , Ltd.
China
Product Name: bronopol
Price: ￥Inquiry/25kg
Purity: 99.0%
Delivery: Inquiry
Contact: Wang Jie
Email: 3096638339@qq.com

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Price: $66/10mM*1mLinDMSO

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bronopol

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