Glycolic acid

Modify Date: 2025-08-20 14:17:44

Glycolic acid structure	Common Name	Glycolic acid
	CAS Number	79-14-1	Molecular Weight	76.051
	Density	1.4±0.1 g/cm3	Boiling Point	265.6±13.0 °C at 760 mmHg
	Molecular Formula	C₂H₄O₃	Melting Point	75-80 °C(lit.)
	MSDS	Chinese USA	Flash Point	128.7±16.3 °C
	Symbol	GHS05, GHS07	Signal Word	Danger

Use of Glycolic acid

Glycolic Acid is an inhibitor of tyrosinase, suppressing melanin formation and lead to a lightening of skin colour.

Name	glycolic acid
Synonym	More Synonyms

Description	Glycolic Acid is an inhibitor of tyrosinase, suppressing melanin formation and lead to a lightening of skin colour.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Tyrosinase Natural Products >> Others Research Areas >> Metabolic Disease
Target	Human Endogenous Metabolite
In Vitro	Different concentrations of Glycolic Acid (GA) or LA (300 and 500 mg/mL) are tested on the growth of mouse and human melanoma cells. Both types of cells grow well, even in the presence of 300 mg/mL of each chemical for 5 days. However, 500 mg/mL Glycolic Acid inhibits the cell growth of mouse melanoma cells (41%) and humanmelanoma cells (27%), and 500 mg/mL of LA inhibits the growth of mouse melanoma cells (36%)[1].
Cell Assay	HM3KO pigmented human melanoma cells and B16 mouse melanoma cells are cultured in Dulbecco’s modified Eagles medium supplemented with 10%fetal calf serum and appropriate amounts of antibiotics and fungizone were dissolved at a concentration of 100mg/mL in distilled water. These chemicals (e.g., Glycolic Acid ) are added to the cell cultures at final concentrations of 300 or 500 mg/mL every 2 days for 5 days[1].
References	[1]. Usuki A, et al. The inhibitory effect of glycolic acid and lactic acid on melanin synthesis in melanoma cells. Exp Dermatol. 2003;12 Suppl 2:43-50.

Density	1.4±0.1 g/cm3
Boiling Point	265.6±13.0 °C at 760 mmHg
Melting Point	75-80 °C(lit.)
Molecular Formula	C₂H₄O₃
Molecular Weight	76.051
Flash Point	128.7±16.3 °C
Exact Mass	76.016045
PSA	57.53000
LogP	-1.05
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.450
Storage condition	2-8°C
Stability	Stable. Incompatible with bases, oxidizing agents and reducing agents.
Water Solubility	SOLUBLE

Glycolic acid MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MC5250000

CHEMICAL NAME :: Glycolic acid

CAS REGISTRY NUMBER :: 79-14-1

BEILSTEIN REFERENCE NO. :: 1209322

LAST UPDATED :: 199801

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C2-H4-O3

MOLECULAR WEIGHT :: 76.06

WISWESSER LINE NOTATION :: QV1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 29,1363,1946 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1950 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Gastrointestinal - other changes Kidney, Ureter, Bladder - other changes

REFERENCE :: JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 23,259,1941

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,656,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1920 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Gastrointestinal - other changes Kidney, Ureter, Bladder - other changes

REFERENCE :: JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 23,259,1941 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2480 gm/kg/35W-C

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

REFERENCE :: ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.31- 1951- Volume(issue)/page/year: 84,183,1959

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2 gm/m3/6H/2W-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0546415 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 9 gm/kg

SEX/DURATION :: female 7-12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - other effects Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 53,117,1996 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 35260 No. of Facilities: 2991 (estimated) No. of Industries: 27 No. of Occupations: 29 No. of Employees: 29291 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 35260 No. of Facilities: 5782 (estimated) No. of Industries: 64 No. of Occupations: 63 No. of Employees: 191563 (estimated) No. of Female Employees: 98538 (estimated)

Symbol	GHS05, GHS07
Signal Word	Danger
Hazard Statements	H314-H332
Precautionary Statements	P261-P280-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	C:Corrosive
Risk Phrases	R22;R34
Safety Phrases	S26-S36/37/39-S45-S23
RIDADR	UN 3265 8/PG 3
WGK Germany	1
RTECS	MC5250000
Packaging Group	II
Hazard Class	8
HS Code	2918199090

Precursor 9
CAS#:50-00-0 Formaldehyde CAS#:201230-82-2 carbon monoxide CAS#:7044-96-4 propanoyloxymet... CAS#:96-35-5 Methyl glycolate
CAS#:56-81-5 Glycerol CAS#:67-47-0 5-hydroxymethyl... CAS#:56-40-6 Glycine CAS#:110-88-3 trioxane
CAS#:105-39-5 ethyl chloroacetate
DownStream 10
CAS#:110177-81-6 4H-Imidazo[4,5,... CAS#:56-40-6 Glycine CAS#:74-89-5 methylamine CAS#:105459-05-0 2-(tert-butyldi...
CAS#:39096-01-0 2-HYDROXY-N,N-D... CAS#:33581-77-0 Trimethylsilyl ... CAS#:354-38-1 2,2,2-Trifluoro... CAS#:55982-15-5 N-(trimethylsil...
CAS#:4423-79-4 2,2-Pentamethyl... CAS#:4856-97-7 (1H-Benzoimidaz...

HS Code	2918199090
Summary	2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Safety and biocompatibility of carbohydrate-functionalized polyanhydride nanoparticles.

AAPS J. 17(1) , 256-67, (2015)

Carbohydrate functionalization of nanoparticles allows for targeting of C-type lectin receptors. This family of pattern recognition receptors expressed on innate immune cells, such as macrophages and ...

Physiology and pathophysiology of organic acids in cerebrospinal fluid.

J. Inherit. Metab. Dis. 16(4) , 648-69, (1993)

Concentrations of organic acids in cerebrospinal fluid (CSF) appear to be directly dependent upon their rate of production in the brain. There is evidence that the net release of short-chain monocarbo...

HMDB: a knowledgebase for the human metabolome.

Nucleic Acids Res. 37(Database issue) , D603-10, (2009)

The Human Metabolome Database (HMDB, http://www.hmdb.ca) is a richly annotated resource that is designed to address the broad needs of biochemists, clinical chemists, physicians, medical geneticists, ...

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Glycolic acid
Price: Check
Purity: 98.0%
Delivery: 10 Day
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Glycolic acid
Price: ￥248.0/500g ￥88.0/100g
Purity: 98.0%
Delivery: Inquiry
Contact: Liu jia
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DC Chemicals Limited
China
Product Name: Hydroxyacetic acid
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Delivery: 3 Day
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Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Glycolic acid
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Glycolic acid
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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Price: ￥550/10 mM * 1 mL in DMSO

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Glycolic acid

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