NORARTOCARPETIN
Modify Date: 2026-06-30 21:58:17
NORARTOCARPETIN structure
|
Common Name | NORARTOCARPETIN | ||
|---|---|---|---|---|
| CAS Number | 520-30-9 | Molecular Weight | 286.23600 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C15H10O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of NORARTOCARPETINNorartocarpetin is a tyrosinase inhibitor. Norartocarpetin has strong tyrosinase inhibitory activity with an IC50 value of 0.47 μM. Norartocarpetin as an antibrowning agent can be used for the research of food systems. Norartocarpetin also has a significant anticancer activity in lung carcinoma cells (NCI-H460) with an IC50 value of 22 μM. Norartocarpetin has antiproliferative effects are mediated via targeting Ras/Raf/MAPK signalling pathway, mitochondrial mediated apoptosis, S-phase cell cycle arrest and suppression of cell migration and invasion in human lung carcinoma cells[1][2]. |
| Name | 2-(2,4-dihydroxyphenyl)-5,7-dihydroxychromen-4-one |
|---|---|
| Synonym | More Synonyms |
| Description | Norartocarpetin is a tyrosinase inhibitor. Norartocarpetin has strong tyrosinase inhibitory activity with an IC50 value of 0.47 μM. Norartocarpetin as an antibrowning agent can be used for the research of food systems. Norartocarpetin also has a significant anticancer activity in lung carcinoma cells (NCI-H460) with an IC50 value of 22 μM. Norartocarpetin has antiproliferative effects are mediated via targeting Ras/Raf/MAPK signalling pathway, mitochondrial mediated apoptosis, S-phase cell cycle arrest and suppression of cell migration and invasion in human lung carcinoma cells[1][2]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 0.47 μM (tyrosinase);[1] IC50: 22 μM (NCI-H460 cells); 85 μM (MRC-9 cells)[2] |
| In Vitro | Norartocarpetin has strong mushroom tyrosinase inhibitory activity with an IC50 value of 0.47 μM[1]. Norartocarpetin (0-100 μM; 48 h) leds to dose-dependent cytotoxic effects in NCI-H460 cells and MRC-9 cells with IC50 values of 22 μM and 85 μM, respectively[2]. Norartocarpetin (0, 11, 22, and 44 μM; 24 h) led to blockade of Ras/Raf/MAPK signalling pathway[2]. Norartocarpetin (0, 11, 22, and 44 μM, 24 h) induced the apoptosis of the human lung carcinoma cells (NCI-H460)[2]. Norartocarpetin (0, 11, 22, and 44 μM) leds to S-phase cell cycle arrest[2]. Norartocarpetin (22 μM; 24 h) leds to dose-dependent suppression of cell invasion[2]. Norartocarpetin (0, 11, 22, and 44 μM, 24 h) leds to significant inhibition of cell migration[2]. Cell Viability Assay[2] Cell Line: MRC-9 (normal fibroblast lung cells) and NCI-H460 (human lung cancer cells) Concentration: 0, 3.12, 6.25, 12.5, 25, 50, and 100 μM (first dissolved in DMSO at 1.0 mg/mL and then diluted to different concentrations using DMSO, 30 μL, 20min) Incubation Time: 48 h Result: Repressed the viability of NCI-H460 cells in a dose-dependent manner. Western Blot Analysis[2] Cell Line: MRC-9 and NCI-H460 cells Concentration: 0, 11, 22, and 44 μM Incubation Time: 24 h Result: Significantly reduced the expression of p-RAS, p-RAF and p-P38 and unchanged the expressions of RAS, RAF and P38. Apoptosis Analysis[2] Cell Line: MRC-9 and NCI-H460 cells Concentration: 0. 11, 22 and 44 μM Incubation Time: 24 h Result: Led to dose-dependent apoptosis and induced DNA damage. Cell Cycle Analysis[2] Cell Line: MRC-9 and NCI-H460 cells Concentration: 0, 11, 22, and 44 μM Incubation Time: Result: Showed increase of S-phase cells and the percentage of S-phase NCI-H460 LC cells was 30%, 40%, 55% and 70% at 0, 11, 22 and 44 μM concentrations, respectively. Cell Invasion AssayMRC-9 and NCI-H460 cells Cell Line: MRC-9 and NCI-H460 cells Concentration: 22 μM Incubation Time: 24 h Result: Significantly reducted (from 100% to about 40%) in the invasion of NCI-H460 human LC cells. Cell Migration Assay [2] Cell Line: MRC-9 and NCI-H460 cells Concentration: 0, 11, 22, and 44 μM Incubation Time: 24 h Result: Decreased remarkably the cell invasion in NCI-H460 LC cells in a concentration- dependent manner. |
| Molecular Formula | C15H10O6 |
|---|---|
| Molecular Weight | 286.23600 |
| Exact Mass | 286.04800 |
| PSA | 111.13000 |
| LogP | 2.28240 |
| InChIKey | ZSYPIPFQOQGYHH-UHFFFAOYSA-N |
| SMILES | O=c1cc(-c2ccc(O)cc2O)oc2cc(O)cc(O)c12 |
| HS Code | 2914501900 |
|---|
| Precursor 9 | |
|---|---|
| DownStream 0 | |
CAS#:72357-29-0
CAS#:744210-77-3
CAS#:90-24-4
CAS#:273211-51-1
CAS#:65612-84-2
CAS#:2150-41-6
CAS#:5446-02-6
CAS#:58124-14-4
CAS#:53931-00-3| HS Code | 2914501900 |
|---|---|
| Summary | 2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0% |
|
Name: Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induc...
Source: ChEMBL
Target: RAW264.7
External Id: CHEMBL4407190
|
|
Name: Inhibition of rat neutrophils beta-glucuronidase at 100 uM relative to control
Source: ChEMBL
Target: Beta-glucuronidase
External Id: CHEMBL4616972
|
|
Name: Inhibition of Clostridium welchii neuraminidase
Source: ChEMBL
Target: N/A
External Id: CHEMBL1048098
|
|
Name: Inhibition of human PTP1B using p-nitrophenyl phosphate as substrate preincubated for...
Source: ChEMBL
Target: Tyrosine-protein phosphatase non-receptor type 1
External Id: CHEMBL4253918
|
|
Name: Inhibition of Mycobacterium tuberculosis PtpA using p-nitrophenyl phosphate as substr...
Source: ChEMBL
Target: Low molecular weight protein-tyrosine phosphatase A
External Id: CHEMBL4253917
|
|
Name: Inhibition of mushroom tyrosinase assessed as reduction in diphenolase activity using...
Source: ChEMBL
Target: Polyphenol oxidase 2
External Id: CHEMBL2342381
|
|
Name: Inhibition of LYP (unknown origin) using p-nitrophenyl phosphate as substrate preincu...
Source: ChEMBL
Target: Tyrosine-protein phosphatase non-receptor type 22
External Id: CHEMBL4253920
|
|
Name: Inhibition of porcine pancreatic lipase using p-nitrophenylbutyrate as substrate asse...
Source: ChEMBL
Target: Pancreatic triacylglycerol lipase
External Id: CHEMBL3424041
|
|
Name: Selectivity index, ratio of IC50 for human PTP1B to IC50 for Mycobacterium tuberculos...
Source: ChEMBL
Target: N/A
External Id: CHEMBL4253919
|
|
Name: Inhibition of porcine pancreatic lipase using p-nitrophenylbutyrate as substrate asse...
Source: ChEMBL
Target: Pancreatic triacylglycerol lipase
External Id: CHEMBL3424042
|
Total 24, Current Page 1 of 3
1
2
3
| Norartocarpetin |
| 2-(2,4-Dihydroxy-phenyl)-5,7-dihydroxy-1-benzopyran-4-one |