Dequalinium Chloride
Modify Date: 2024-01-02 14:50:08
Dequalinium Chloride structure
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Common Name | Dequalinium Chloride | ||
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| CAS Number | 522-51-0 | Molecular Weight | 527.571 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C30H40Cl2N4 | Melting Point | ≥300 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | N/A | |
Use of Dequalinium ChlorideDequalinium Chloride is a selective blocker of apamin-sensitive K+ channels.Target: Potassium ChannelDequalinium Chloride is a selective blocker of apamin-sensitive K+ channels. Treatment with Dequalinium chloride did not influence conditions caused by haemolytic streptococci -- verified by bacteriological examinations of pharyngeal smears -- inspite of its efficiency in vitro [1]. Dequalinium chloride (DECA), a cationic, lipophilic mitochondrial poison, selectively targets the mitochondrial membrane of certain epithelial carcinoma cells, in which it inhibits cellular energy production. Higher DECA doses under either regimen induced severe toxic effects and mortality [2]. |
| Name | dequalinium chloride |
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| Synonym | More Synonyms |
| Description | Dequalinium Chloride is a selective blocker of apamin-sensitive K+ channels.Target: Potassium ChannelDequalinium Chloride is a selective blocker of apamin-sensitive K+ channels. Treatment with Dequalinium chloride did not influence conditions caused by haemolytic streptococci -- verified by bacteriological examinations of pharyngeal smears -- inspite of its efficiency in vitro [1]. Dequalinium chloride (DECA), a cationic, lipophilic mitochondrial poison, selectively targets the mitochondrial membrane of certain epithelial carcinoma cells, in which it inhibits cellular energy production. Higher DECA doses under either regimen induced severe toxic effects and mortality [2]. |
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| Related Catalog | |
| References |
| Melting Point | ≥300 °C(lit.) |
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| Molecular Formula | C30H40Cl2N4 |
| Molecular Weight | 527.571 |
| Exact Mass | 526.263000 |
| PSA | 59.80000 |
| LogP | 1.34060 |
| Storage condition | 2-8°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| Hazard Codes | Xi:Irritant; |
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| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | VA0700000 |
| HS Code | 2933499090 |
| HS Code | 2933499090 |
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| Summary | 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Antimicrobial topical agents used in the vagina.
Curr. Probl. Dermatol. 40 , 36-47, (2011) Vaginally applied antimicrobial agents are widely used in the vagina in women with lower genital tract infections. An 'antimicrobial' is a general term that refers to a group of drugs that are effecti... |
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Dequalinium induces cytotoxicity in human leukemia NB4 cells by downregulation of Raf/MEK/ERK and PI3K/Akt signaling pathways and potentiation of specific inhibitors of these pathways.
Leuk. Res. 38(7) , 795-803, (2014) Delocalized lipophilic cation dequalinium (DQA) selectively accumulates in mitochondria and displays anticancer activity in different malignancies. Our previous studies indicate a DQA-induced cytotoxi... |
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N-palmitoyl-ethanolamine (PEA) induces peripheral antinociceptive effect by ATP-sensitive K+-channel activation.
J. Pharmacol. Sci. 118(2) , 156-60, (2012) Although the antinociceptive effects of N-palmitoyl-ethanolamine (PEA) were first characterized nearly 50 years ago, the identity of the mechanism that mediates these actions has not been elucidated. ... |
| Quinolinium, 1,1'-(1,10-decanediyl)bis[4-amino-2-methyl-, dichloride |
| DECA |
| efisol |
| dekamin |
| evazol |
| le chlorure de dequalinium |
| dekadin |
| EINECS 208-330-9 |
| 1,1'-Decan-1,10-diylbis(4-amino-2-methylchinolinium)dichlorid |
| BADQ-10 |
| 1,1'-(1,10-Decanediyl)bis(4-amino-2-methylquinolinium) dichloride |
| dequadin |
| eriosept |
| 1,1'-Decane-1,10-diylbis(4-amino-2-methylquinolinium) dichloride |
| Dequalinium Chloride |
| dequavet |
| baqd10 |
| Dequadin chloride |
| Quinolinium, 1,1'-(1,10-decanediyl)bis[4-amino-2-methyl-, chloride (1:2) |
| MFCD00063502 |
| Dequalinium (Chloride) |