Dauricine

Modify Date: 2026-07-01 18:23:27

Dauricine structure	Common Name	Dauricine
	CAS Number	524-17-4	Molecular Weight	624.766
	Density	1.2±0.1 g/cm3	Boiling Point	712.3±60.0 °C at 760 mmHg
	Molecular Formula	C₃₈H₄₄N₂O₆	Melting Point	115ºC
	MSDS	N/A	Flash Point	384.6±32.9 °C

Use of Dauricine

Dauricine, a bisbenzylisoquinoline alkaloid in Asiatic Moonseed Rhizome, possesses anti-inflammatory activity. Dauricine inhibits cell proliferation and invasion, and induces apoptosis by suppressing NF-κB activation in a dose- and time-dependent manner in colon cancer[1].

Name	dauricine
Synonym	More Synonyms

Description	Dauricine, a bisbenzylisoquinoline alkaloid in Asiatic Moonseed Rhizome, possesses anti-inflammatory activity. Dauricine inhibits cell proliferation and invasion, and induces apoptosis by suppressing NF-κB activation in a dose- and time-dependent manner in colon cancer[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Inflammation/Immunology
References	[1]. Yang Z, et al. Dauricine induces apoptosis, inhibits proliferation and invasion through inhibiting NF-kappaB signaling pathway in colon cancer cells. J Cell Physiol. 2010 Oct;225(1):266-75.

Density	1.2±0.1 g/cm3
Boiling Point	712.3±60.0 °C at 760 mmHg
Melting Point	115ºC
Molecular Formula	C₃₈H₄₄N₂O₆
Molecular Weight	624.766
Flash Point	384.6±32.9 °C
Exact Mass	624.319946
PSA	72.86000
LogP	6.61
Vapour Pressure	0.0±2.4 mmHg at 25°C
Index of Refraction	1.601
InChIKey	AQASRZOCERRGBL-ROJLCIKYSA-N
SMILES	COc1cc2c(cc1OC)C(Cc1ccc(Oc3cc(CC4c5cc(OC)c(OC)cc5CCN4C)ccc3O)cc1)N(C)CC2
Storage condition	2-8 °C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SM9490000

CHEMICAL NAME :: Phenol, 4-((1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoqu inolinyl)methyl)-2-(4 -((1,2,3,4- tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl)met hyl)phenoxy)-, (R-(R*,R*))-

CAS REGISTRY NUMBER :: 524-17-4

LAST UPDATED :: 198906

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C38-H44-N2-O6

MOLECULAR WEIGHT :: 624.84

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For publisher information, see ZYZAEU. Volume(issue)/page/year: 23,182,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 185 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 7,419,1986

Hazard Codes	Xi

Name: Toxicity in ip dosed rat
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL1018919

Name: Inhibitory concentration against IKr potassium channel
Source: ChEMBL
Target: Potassium voltage-gated channel subfamily H member 2
External Id: CHEMBL827807

Name: Inhibition of P-glycoprotein-mediated Rhodamine-123 efflux in human MOLT4/DNR cells a...
Source: ChEMBL
Target: ATP-dependent translocase ABCB1
External Id: CHEMBL4624258

Name: Cytotoxicity against human HepG2 cells overexpressing EGFP-CYP3A4 assessed as reducti...
Source: ChEMBL
Target: HepG2
External Id: CHEMBL4774606

Name: Inhibition of formyl-methionyl-leucyl-phenylalanine induced superoxide generation in ...
Source: ChEMBL
Target: N/A
External Id: CHEMBL1018099

Name: HIV Cellular Data
Source: NIAID
Target: N/A
External Id: HIV Cellular Data

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[R-(R*,R*)]-4-[(1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl)methyl]-2-[4-[(1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl)methyl]phenoxy]phenol

6,6'-Di-O-Methyldauricoline

4-{[(1R)-6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}-2-(4-{[(1R)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}phenoxy)phenol

4-{[(1R)-6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydro-1-isoquinolinyl]methyl}-2-(4-{[(1R)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydro-1-isoquinolinyl]methyl}phenoxy)phenol

Dauricine

Dauricine (8CI)

Menispermum dauricum DC Extract

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Dauricine

Use of Dauricine

Names

Dauricine Biological Activity

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Safety Information

DauricineBioassay

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.