Crimidine

Modify Date: 2025-08-25 12:29:25

Crimidine structure	Common Name	Crimidine
	CAS Number	535-89-7	Molecular Weight	171.627
	Density	1.2±0.1 g/cm3	Boiling Point	291.2±20.0 °C at 760 mmHg
	Molecular Formula	C₇H₁₀ClN₃	Melting Point	87ºC
	MSDS	Chinese USA	Flash Point	129.9±21.8 °C
	Symbol	GHS06	Signal Word	Danger

Use of Crimidine

Crimidine is a convulsant poison used as a rodenticide. Crimidine was originally known by its product name, Castrix. It was originally produced in the 1940s by the conglomerate, IG Farben.

Name	crimidine
Synonym	More Synonyms

Density	1.2±0.1 g/cm3
Boiling Point	291.2±20.0 °C at 760 mmHg
Melting Point	87ºC
Molecular Formula	C₇H₁₀ClN₃
Molecular Weight	171.627
Flash Point	129.9±21.8 °C
Exact Mass	171.056320
PSA	29.02000
LogP	1.73
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.568
InChIKey	HJIUPFPIEBPYIE-UHFFFAOYSA-N
SMILES	Cc1cc(N(C)C)nc(Cl)n1

Crimidine MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UV8050000

CHEMICAL NAME :: Pyrimidine, 2-chloro-4-(dimethylamino)-6-methyl-

CAS REGISTRY NUMBER :: 535-89-7

BEILSTEIN REFERENCE NO. :: 0127995

LAST UPDATED :: 199612

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C7-H10-Cl-N3

MOLECULAR WEIGHT :: 171.65

WISWESSER LINE NOTATION :: T6N CNJ BG DN1&1 F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1250 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information Canada, 171 Slater St., Ottawa, Ont., Canada) Volume(issue)/page/year: 6,139,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86 Volume(issue)/page/year: A099,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 37,307,1948

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1250 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971 Volume(issue)/page/year: -,422,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1200 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,405,1989

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 420 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 37,307,1948

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 500 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 37,307,1948

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 5 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College Science Pub., 1969 Volume(issue)/page/year: 5,59,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 5 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 37,307,1948

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 5 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971 Volume(issue)/page/year: -,422,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 2660 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PCOC** Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. (Topeka, KS) Volume(issue)/page/year: -,202,1966

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 2660 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 37,307,1948

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 22500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85DPAN "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976 Volume(issue)/page/year: -,-,1971/1976

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H300
Precautionary Statements	P301 + P310 + P330
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	T+:Verytoxic;
Risk Phrases	R28
Safety Phrases	S36/37-S45
RIDADR	UN 2811
RTECS	UV8050000
Packaging Group	I
Hazard Class	6.1(a)
HS Code	2933599017

2,4-Dichloro-6-...

CAS#:5424-21-5

Dimethylamine

CAS#:124-40-3

~41%

Crimidine

CAS#:535-89-7

Literature: Semple, Graeme; Tran, Thuy-Anh; Kramer, Bryan; Hsu, Debbie; Han, Sangdon; Choi, Juyi; Vallar, Pureza; Casper, Martin D.; Zou, Ning; Hauser, Erin K.; Thomsen, William; Whelan, Kevin; Sengupta, Dipanjan; Morgan, Michael; Sekiguchi, Yoshinori; Kanuma, Kosuke; Chaki, Shigeyuki; Grottick, Andrew J. Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 21 p. 6166 - 6171

2,4-Dichloro-6-...

CAS#:5424-21-5

Dimethylamine

CAS#:124-40-3

Crimidine

CAS#:535-89-7

(4-Chloro-6-met...

CAS#:5734-62-3

Literature: WO2005/95357 A2, ; Page/Page column 137; 138 ; WO 2005/095357 A2

Precursor 2
CAS#:5424-21-5 2,4-Dichloro-6-... CAS#:124-40-3 Dimethylamine
DownStream 1
CAS#:77940-23-9 2-[4-(dimethyla...

HS Code	2933599017
Summary	2933599017 2-chloro-n,n,6-trimethylpyrimidin-4-amine。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:20.0%

[Single dose of 2 acute rodenticides used in a village].

Zhonghua Liu Xing Bing Xue Za Zhi 6(5) , 296-9, (1985)

Pyridoxine in clinical toxicology: a review.

Eur. J. Emerg. Med. 12(2) , 78-85, (2005)

Pyridoxine (vitamin B6) is a co-factor in many enzymatic pathways involved in amino acid metabolism: the main biologically active form is pyridoxal 5-phosphate. Pyridoxine has been used as an antidote...

[Serial determination of crimidine by HPLC/SE/SM in a patient ingesting a "mouse trap"].

Acta Clin. Belg. Suppl. (1) , 8-11, (2002)

Crimidine (2 chloro, 4 methyl, 6 dimethyl amidopyrine) is a synthetic rodenticide which causes acute poisonings after oral ingestion in human. Major toxic effects are consciousness disorders, hyperton...

Name: qHTS for Inhibitors of Polymerase Kappa
Source: NCGC
Target: DNA polymerase kappa [Homo sapiens]
External Id: PolK100

Name: Inhibition of phosphatidyl serine liposome-stimulated sheep brain dynamin 1 GTPase ac...
Source: ChEMBL
Target: N/A
External Id: CHEMBL4001158

Name: qHTS for Inhibitors of binding or entry into cells for Marburg Virus
Source: NCGC
Target: gene 4 small orf - Marburg virus
External Id: VSVM-OFFLINE

Name: qHTS for Inhibitors of binding or entry into cells for Lassa Virus
Source: NCGC
Target: N/A
External Id: VSVL-OFFLINE

Total 4, Current Page 1 of 1

2-chloro-N,N,6-trimethylpyrimidin-4-amine

Crimidin

2-Chloro-4-(dimethylamino)-6-methylpyrimidine

Crimidina [Italian]

2-Chloro-4-dimethylamino-6-methylpyrimidine

Crimidine

Crimidine [ISO:BSI]

MFCD00055517

Caswell No. 188

2-chloro-4-dimethylamino-6-methyl-pyrimidine

Castrix

EINECS 208-622-6

Crimidin [German]

2-dimethylamino-4-chloro-6-methylpyrimidine

(2-Chlor-6-methyl-pyrimidin-4-yl)-dimethyl-amin

2-Chlor-N,N,6-trimethylpyrimidin-4-amin

2-Chloro-N,N,6-trimethyl-4-pyrimidinamine

Crimidina

T6N CNJ BG DN1&1 F1

(2-chloro-6-methyl-pyrimidin-4-yl)-dimethyl-amine

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Crimidine

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CrimidineBioassay

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.