Muscone

Modify Date: 2024-01-02 18:37:26

Muscone structure	Common Name	Muscone
	CAS Number	541-91-3	Molecular Weight	238.409
	Density	0.8±0.1 g/cm3	Boiling Point	329.5±10.0 °C at 760 mmHg
	Molecular Formula	C₁₆H₃₀O	Melting Point	33ºC
	MSDS	N/A	Flash Point	145.3±11.3 °C

Use of Muscone

Muscone is the main active monomer of traditional Chinese medicine musk. Muscone inhibits NF-κB and NLRP3 inflammasome activation. Muscone remarkably decreases the levels of inflammatory cytokines (IL-1β, TNF-α and IL-6), and ultimately improves cardiac function and survival rate[1].

Name	3-Methylcyclopentadecanone
Synonym	More Synonyms

Description	Muscone is the main active monomer of traditional Chinese medicine musk. Muscone inhibits NF-κB and NLRP3 inflammasome activation. Muscone remarkably decreases the levels of inflammatory cytokines (IL-1β, TNF-α and IL-6), and ultimately improves cardiac function and survival rate[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Immunology/Inflammation >> Interleukin Related Signaling Pathways >> Immunology/Inflammation >> NOD-like Receptor (NLR) Research Areas >> Inflammation/Immunology
Target	NF-κB NLRP3 TNF-α IL-1β IL-6
In Vitro	Muscone significantly downregulates the levels of LPS-induced inflammatory cytokines and inhibits NF-κB and NLRP3 inflammasome activation in Bone marrow-derived macrophages (BMDMs). Muscone serves as a promising and effective drug for post-myocardial infarction (MI) treatment[1].
References	[1]. Du Y, et al. Muscone improves cardiac function in mice after myocardial infarction by alleviating cardiac macrophage-mediated chronic inflammation through inhibition of NF-κB and NLRP3 inflammasome. Am J Transl Res. 2018 Dec 15;10(12):4235-4246.

Density	0.8±0.1 g/cm3
Boiling Point	329.5±10.0 °C at 760 mmHg
Melting Point	33ºC
Molecular Formula	C₁₆H₃₀O
Molecular Weight	238.409
Flash Point	145.3±11.3 °C
Exact Mass	238.229660
PSA	17.07000
LogP	6.33
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.437
Storage condition	-20°C

Muscone MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GY0950000

CHEMICAL NAME :: Cyclopentadecanone, 3-methyl-

CAS REGISTRY NUMBER :: 541-91-3

LAST UPDATED :: 199701

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C16-H30-O

MOLECULAR WEIGHT :: 238.46

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,749,1982 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,749,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 270 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

REFERENCE :: CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 12,236,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 152 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 12,236,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,749,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - A1797 No. of Facilities: 33 (estimated) No. of Industries: 2 No. of Occupations: 17 No. of Employees: 2333 (estimated)

Safety Phrases	26-36
WGK Germany	2
RTECS	MH7875000
HS Code	2914700090

HS Code	2914700090
Summary	HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%

EINECS 208-795-8

MFCD00211114

FEMA 3434

Musk

Cyclopentadecanone, 3-methyl-

3-Methylcyclopentadecanone

Muskone

DL-MUSCONE

dl-Muscone or 3-Methylcyclopentadecanone

Musk Ketone

moschusketone

MUSCONE

MUSCONE II

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Muscone
Price: ￥Inquiry/1mg ￥875.0/5g ￥275.0/1g
Purity: 98.0%
Stocking Period: 1 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: 3-Methylcyclopentadecanone
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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Price: ￥49.6/250mg

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Muscone

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