Nicardipine Hydrochloride structure
|
Common Name | Nicardipine Hydrochloride | ||
---|---|---|---|---|
CAS Number | 54527-84-3 | Molecular Weight | 515.986 | |
Density | N/A | Boiling Point | 603.4ºC at 760 mmHg | |
Molecular Formula | C26H30ClN3O6 | Melting Point | 176-1780C | |
MSDS | Chinese USA | Flash Point | 318.7ºC | |
Symbol |
GHS06 |
Signal Word | Danger |
Use of Nicardipine HydrochlorideNicardipine Hcl(YC-93) is a calcium channel blocker that has been widely used to control blood pressure in severe hypertension following events such as ischemic stroke, traumatic brain injury, and intracerebral hemorrhage. |
Name | Nicardipine hydrochloride |
---|---|
Synonym | More Synonyms |
Description | Nicardipine Hcl(YC-93) is a calcium channel blocker that has been widely used to control blood pressure in severe hypertension following events such as ischemic stroke, traumatic brain injury, and intracerebral hemorrhage. |
---|---|
Related Catalog | |
References |
Boiling Point | 603.4ºC at 760 mmHg |
---|---|
Melting Point | 176-1780C |
Molecular Formula | C26H30ClN3O6 |
Molecular Weight | 515.986 |
Flash Point | 318.7ºC |
Exact Mass | 515.182312 |
PSA | 113.69000 |
LogP | 5.33180 |
Storage condition | 2-8°C |
Water Solubility | DMSO: ~1 mg/mL |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
Symbol |
GHS06 |
---|---|
Signal Word | Danger |
Hazard Statements | H301-H311-H331 |
Precautionary Statements | P261-P280-P301 + P310-P311 |
Personal Protective Equipment | Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges |
Hazard Codes | T: Toxic; |
Risk Phrases | R23/24/25 |
Safety Phrases | S36/37/39-S45 |
RIDADR | UN 2811 6.1/PG 3 |
WGK Germany | 3 |
RTECS | US7972100 |
Packaging Group | III |
Hazard Class | 6.1(b) |
~31% Nicardipine Hyd... CAS#:54527-84-3 |
Literature: Navinta LLC. Patent: US2008/125595 A1, 2008 ; Location in patent: Page/Page column 6-7 ; |
~% Nicardipine Hyd... CAS#:54527-84-3 |
Literature: US3985758 A1, ; |
~67% Nicardipine Hyd... CAS#:54527-84-3 |
Literature: Ohno; Komatsu; Mizukoshi; Ichihara; Nakamura; Morishima; Sumita Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 4 p. 1589 - 1606 |
~% Nicardipine Hyd... CAS#:54527-84-3 |
Literature: Chemical and Pharmaceutical Bulletin, , vol. 34, # 4 p. 1589 - 1606 |
Precursor 8 | |
---|---|
DownStream 1 | |
Activity Profile of an FDA-Approved Compound Library against Schistosoma mansoni.
PLoS Negl. Trop. Dis. 9 , e0003962, (2015) As plans to expand mass drug treatment campaigns to fight schistosomiasis form, worries about reliance on praziquantel as the sole available treatment motivate the investigation for novel antischistos... |
|
Method development for impurity profiling in SFC: The selection of a dissimilar set of stationary phases.
J. Pharm. Biomed. Anal. 111 , 333-43, (2015) Supercritical fluid chromatography (SFC) is drawing considerable interest as separation technique in the pharmaceutical industry. The technique is already well established in chiral separations both a... |
|
The glucocorticoid mometasone furoate is a novel FXR ligand that decreases inflammatory but not metabolic gene expression.
Sci. Rep. 5 , 14086, (2015) The Farnesoid X receptor (FXR) regulates bile salt, glucose and cholesterol homeostasis by binding to DNA response elements, thereby activating gene expression (direct transactivation). FXR also inhib... |
2-[benzyl(methyl)amino]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride |
UNII:K5BC5011K3 |
dafil |
EINECS 259-198-4 |
2-[Benzyl(methyl)amino]ethyl-methyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridin-3,5-dicarboxylathydrochlorid |
MFCD00057327 |
Barizin |
Cardene |
Nicardipine HCl |
lincil |
2-[Benzyl(methyl)amino]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate hydrochloride (1:1) |
2-(benzyl(methyl)amino)ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate hydrochloride |
loxen |
Aprovan |
dagan |
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 2-[methyl(phenylmethyl)amino]ethyl ester, hydrochloride (1:1) |
NICODEL |
2-(Benzyl(methyl)amino)ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)pyridine-3,5-dicarboxylate hydrochloride |
1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)methyl-2-[methyl(phenylmethyl)amino]-3,5-pyridinedicarboxylic acid ethyl ester hydrochloride |
Dacarel |
YC-93 |
2-[Benzyl(methyl)amino]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride (1:1) |
3,5-pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 2-[methyl(phenylmethyl)amino]ethyl ester, monohydrochloride |
(+/-)-2-(benzyl-methylamino)ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate monohydrochloride |
2,6-diméthyl-4-(3-nitrophényl)-1,4-dihydropyridine-3,5-dicarboxylate de 2-[benzyl(méthyl)amino]éthyle et de méthyle chlorhydrate |
Nicardipine Hydrochloride |
Vasonas |
Nicardipine (Hydrochloride) |