Conessine
Conessine structure
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Common Name | Conessine | ||
|---|---|---|---|---|
| CAS Number | 546-06-5 | Molecular Weight | 356.588 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 450.4±45.0 °C at 760 mmHg | |
| Molecular Formula | C24H40N2 | Melting Point | 126-127ºC | |
| MSDS | Chinese USA | Flash Point | 199.6±16.5 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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[New orientation and new therapeutic weapons in the therapy of intestinal amebiasis].
Minerva Med. 43(59-60) , 129-33, (1952)
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Highly enantioselective construction of fused pyrrolidine systems that contain a quaternary stereocenter: concise formal synthesis of (+)-conessine.
Angew. Chem. Int. Ed. Engl. 43(19) , 2543-6, (2004)
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High-performance thin layer chromatography method for estimation of conessine in herbal extract and pharmaceutical dosage formulations.
J. Pharm. Biomed. Anal. 46(2) , 391-4, (2008) A new, simple, sensitive, precise and robust high-performance thin layer chromatographic (HPTLC) method was developed for the estimation of conessine in herbal extracts and pharmaceutical dosage forms. Analysis of conessine was performed on TLC aluminium plat... |
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Novel H3 receptor antagonists with improved pharmacokinetic profiles.
Bioorg. Med. Chem. Lett. 18(14) , 4133-6, (2008) A new series of H(3) antagonists derived from the natural product Conessine are presented. Several compounds from these new series retain the potency and selectivity of earlier diamine based analogs while exhibiting improved PK characteristics. One compound (... |
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Antimicrobial activity of the methanolic bark extract of Holarrhena pubescens (Buch. Ham), its fractions and the pure compound conessine.
Nat. Prod. Res. 26(11) , 987-92, (2012) The antimicrobial activity of the methanolic extract of the bark of Holarrhena pubescens, its fractions, and conessine, a steroidal alkaloid, was determined against various bacteria and fungi using the agar diffusion method. They were all found to possess sig... |
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Development and validation of a visible absorption densitometry method for quantitation of conessine in Holarrhena antidysenterica (Kurchi).
J. AOAC Int. 91(2) , 339-43, (2008) A selective, precise, and accurate high-performance thin-layer chromatographic (HPTLC) method has been proposed for the analysis of conessine in Holarrhena antidysenterica. The method involves visible densitometric evaluation of conessine resolving it by HPTL... |
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A new family of histamine H3 receptor antagonists based on a natural product: discovery, SAR, and properties of the series.
Inflamm. Res. 56 Suppl 1 , S47-8, (2007)
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[Conessine in the treatment of vaginitis due to Trichomonas].
Presse Med. 58(48) , 853, (1950)
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[Changes in conessine in stem bark of Holarrhena floribunda in Burkina Faso].
Ann. Pharm. Fr. 45(4) , 307-13, (1987)
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[Experimental studies of conessine. Cultures of dysenteric amoeba in mediums to which chlorhydrates of conessine or emetine were previously added].
Ann. Pharm. Fr. 8(5) , 410-4, (1950)
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