Alantolactone

Modify Date: 2024-01-02 16:12:19

Alantolactone Structure
Alantolactone structure
 Common Name Alantolactone
CAS Number 546-43-0 Molecular Weight 232.318
Density 1.1±0.1 g/cm3 Boiling Point 275.0±0.0 °C at 760 mmHg
Molecular Formula C15H20O2 Melting Point 78-79ºC
MSDS Chinese USA Flash Point 111.5±18.2 °C
Symbol GHS07
GHS07		 Signal Word Warning

 Use of Alantolactone


Alantolactone is a selective STAT3 inhibitor, with potent anticancer activity.

 Names

Name alantolactone
Synonym More Synonyms

 Alantolactone Biological Activity

Description Alantolactone is a selective STAT3 inhibitor, with potent anticancer activity.
Related Catalog
Target

STAT3

In Vitro Alantolactone induces apoptosis in HepG2 cells in a dose-dependent manner. This Alantolactone-induced apoptosis is found to be associated with GSH depletion, inhibition of STAT3 activation, ROS generation, mitochondrial transmembrane potential dissipation, and increased Bax/Bcl-2 ratio and caspase-3 activation[1]. Alantolactone decreases STAT3 translocation to the nucleus, its DNA-binding, and STAT3 target gene expression. Alantolactone significantly inhibits STAT3 activation with a marginal effect on MAPKs and on NF-κB transcription; however, this effect is not mediated by inhibiting STAT3 upstream kinases[2].
In Vivo It is found that the average tumor volume in the Alantolactone-treated mice is approximately 2.17-fold lower compared with that in the control mice. However the administration of Alantolactone does not affect the overall bodyweight during the experimental period, suggesting no apparent toxicity. Additionally, the average tumor weight is significantly lower in the Alantolactone-treated mice compared with the control mice. What’s more, the administration of Alantolactone results in a significant decrease in p-STAT3 and cyclin D1 expression in the tumor tissues[2].
Cell Assay Cells are cultured for 24 h before drug treatment in 96 well plates. Cells were treated with Alantolactone (0, 10, 20, 30, 40, 50, and 60 μM) for 12 h and cell viability is measured by MTT assay[1].
Animal Admin Mice[2] Female athymic BALB/c nude mice at the age of 6 weeks are used. MDA-MB-231 cells (5×106 cells/200 μL) are subcutaneously injected into the right flanks of the mice. Ten days after the injection of cells, mice are randomly divided into treatment and control groups (n=5). The animals are administered Alantolactone (2.5 mg/kg of body weight, suspended in DMSO 0.1% v/v, 100 μL i.p. injection) every 2 days, whereas control animals are treated with an equal volume of saline[2].
References

[1]. Khan M, et al. Alantolactone induces apoptosis in HepG2 cells through GSH depletion, inhibition of STAT3 activation, and mitochondrial dysfunction. Biomed Res Int. 2013;2013:719858.

[2]. Chun J, et al. Alantolactone selectively suppresses STAT3 activation and exhibits potent anticancer activity in MDA-MB-231 cells. Cancer Lett. 2015 Feb 1;357(1):393-403.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 275.0±0.0 °C at 760 mmHg
Melting Point 78-79ºC
Molecular Formula C15H20O2
Molecular Weight 232.318
Flash Point 111.5±18.2 °C
Exact Mass 232.146332
PSA 26.30000
LogP 3.69
Vapour Pressure 0.0±0.5 mmHg at 25°C
Index of Refraction 1.534
Storage condition ?20°C

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H317
Precautionary Statements P280
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases 26-36
RIDADR NONH for all modes of transport
HS Code 2932209090

 Customs

HS Code 2932209090
Summary 2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles32

More Articles
Pharmacokinetics, tissue distribution and excretion of isoalantolactone and alantolactone in rats after oral administration of Radix Inulae extract.

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 Synonyms

8b-Hydroxy-4aH-eudesm-5-en-12-oic Acid g-Lactone
Naphtho[2,3-b]furan-2(3H)-one, 3a,5,6,7,8,8a,9,9a-octahydro-5,8a-dimethyl-3-methylene-, (3aR,5S,8aR,9aR)-
(3aR,5S,8aR,9aR)-5,8a-dimethyl-3-methylidene-3a,5,6,7,8,8a,9,9a-octahydronaphtho[2,3-b]furan-2(3H)-one
[3aR-(3aa,5b,8ab,9aa)]-3a,5,6,7,8,8a,9,9a-Octahydro-5,8a-dimethyl-3-methylenenaphtho[2,3-b]furan-2(3H)-one
Inula camphor
ALLANTOLACTONE
MFCD00046915
Helenin
HELENINE
ALANTOLACTONE
Elecampane camphor
ALANTOLACETONE
Eupatal
EINECS 208-899-3
(3aR,5S,8aR,9aR)-5,8a-Dimethyl-3-methylene-3a,5,6,7,8,8a,9,9a-octahydronaphtho[2,3-b]furan-2(3H)-one
Alant camphor
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Related Compounds: More...
alantolactone
80367-94-8
Isoalantolactone
470-17-7
epoxyisoalantolactone
99603-72-2
2-hydroxyalantolactone
68776-45-4
Alantolactone, 4.alpha.,4A.alpha.-epoxy-
65563-75-9
Chemsrc provides Alantolactone(CAS#:546-43-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Alantolactone are included as well.>> amp version: Alantolactone

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