Alantolactone
Alantolactone structure
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Common Name | Alantolactone | ||
|---|---|---|---|---|
| CAS Number | 546-43-0 | Molecular Weight | 232.318 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 275.0±0.0 °C at 760 mmHg | |
| Molecular Formula | C15H20O2 | Melting Point | 78-79ºC | |
| MSDS | Chinese USA | Flash Point | 111.5±18.2 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Pharmacokinetics, tissue distribution and excretion of isoalantolactone and alantolactone in rats after oral administration of Radix Inulae extract.
Molecules 20 , 7719-36, (2015) Radix Inulae is endemic to China and has been used in traditional medicine to treat upper body pain, emesis and diarrhoea, and to eliminate parasites. Here, an UPLC-MS/MS method was developed and applied to study the pharmacokinetics, distribution and excreti... |
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A fluorescence high throughput screening method for the detection of reactive electrophiles as potential skin sensitizers.
Toxicol. Appl. Pharmacol. 289 , 177-84, (2015) Skin sensitization is an important toxicological end-point in the risk assessment of chemical allergens. Because of the complexity of the biological mechanisms associated with skin sensitization, integrated approaches combining different chemical, biological ... |
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Anti-allergic effects of sesquiterpene lactones from the root of Aucklandia lappa Decne.
Mol. Med. Report. 12 , 7789-95, (2015) Aucklandia lappa Decne, a well-known traditional herbal medicine, is used for the treatment of asthma, rheumatism, coughs, tuberculosis and numerous other diseases. The present study evaluated the inhibitory effects of the three sesquiterpene lactones costuno... |
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Alantolactone induces apoptosis in HepG2 cells through GSH depletion, inhibition of STAT3 activation, and mitochondrial dysfunction.
Biomed Res. Int. 2013 , 719858, (2013) Signal transducer and activator of transcription 3 (STAT3) constitutively expresses in human liver cancer cells and has been implicated in apoptosis resistance and tumorigenesis. Alantolactone, a sesquiterpene lactone, has been shown to possess anticancer act... |
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Alantolactone induces G1 phase arrest and apoptosis of multiple myeloma cells and overcomes bortezomib resistance.
Apoptosis 20 , 1122-33, (2015) Several sesquiterpene lactones have been extracted and demonstrated to exert various pharmacological functions in a variety of cancers. Here, we investigated anti-tumor effect of alantolactone, an allergenic sesquiterpene lactone, on human multiple myeloma (M... |
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Alantolactone selectively suppresses STAT3 activation and exhibits potent anticancer activity in MDA-MB-231 cells.
Cancer Lett. 357(1) , 393-403, (2014) The important goal of cancer drug discovery is to develop therapeutic agents that are effective, safe, and affordable. In the present study, we demonstrated that alantolactone, which is a sesquiterpene lactone, has potential activity against triple-negative b... |
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A rapid identification of Radix inulae and its active component alantolactone in the Tibetan medicine Manuxitang.
Biosci. Trends 2(2) , 64-7, (2008) This study sought to establish a more reliable method of identifying the "monarch" or principal drug Radix inulae and its active component alantolactone (AL) in the Tibetan medicine Manuxitang. Radix inulae and AL in Manuxitang were effectively identified by ... |
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Alantolactone induces apoptosis in glioblastoma cells via GSH depletion, ROS generation, and mitochondrial dysfunction.
IUBMB Life 64(9) , 783-94, (2012) Glioblastoma multiforme (GBM) is the most malignant and aggressive primary brain tumor in adults. Despite concerted efforts to improve current therapies, the prognosis of glioblastoma remains very poor. Alantolactone, a sesquiterpene lactone compound, has bee... |
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Helenin inhibition of liver microsomal enzymes.
J. Agric. Food Chem. 30(5) , 988-9, (1982)
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Structure-activity relationship studies on derivatives of eudesmanolides from Inula helenium as toxicants against Aedes aegypti larvae and adults.
Chem. Biodivers. 7(7) , 1681-97, (2010) An Aedes aegypti larval toxicity bioassay was performed on compounds representing many classes of natural compounds including polyacetylenes, phytosterols, flavonoids, sesquiterpenoids, and triterpenoids. Among these compounds, two eudesmanolides, alantolacto... |