Tetramethylbenzidine

Modify Date: 2025-08-20 20:11:47

Tetramethylbenzidine structure	Common Name	Tetramethylbenzidine
	CAS Number	54827-17-7	Molecular Weight	240.343
	Density	1.1±0.1 g/cm3	Boiling Point	368.6±37.0 °C at 760 mmHg
	Molecular Formula	C₁₆H₂₀N₂	Melting Point	168-171 °C(lit.)
	MSDS	USA	Flash Point	210.8±26.0 °C

Use of Tetramethylbenzidine

3,3’,5,5’-Tetramethylbenzidine(TMB) is a chromogenic substrate used in staining procedures in immunohistochemistry as well as being a visualising reagent used in enzyme-linked immunosorbent assays (ELISA).

Name	Tetramethylbenzidine
Synonym	More Synonyms

Description	3,3’,5,5’-Tetramethylbenzidine(TMB) is a chromogenic substrate used in staining procedures in immunohistochemistry as well as being a visualising reagent used in enzyme-linked immunosorbent assays (ELISA).
Related Catalog	Signaling Pathways >> Others >> Others Dye Reagents Research Areas >> Others

Density	1.1±0.1 g/cm3
Boiling Point	368.6±37.0 °C at 760 mmHg
Melting Point	168-171 °C(lit.)
Molecular Formula	C₁₆H₂₀N₂
Molecular Weight	240.343
Flash Point	210.8±26.0 °C
Exact Mass	240.162643
PSA	52.04000
LogP	3.40
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.618
Storage condition	2-8°C
Stability	Stable, but moisture sensitive and may be light sensitive. Incompatible with water, strong oxidizing agents.
Water Solubility	Slightly soluble.

Tetramethylbenzidine MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DV2300000

CHEMICAL NAME :: (1,1'-Biphenyl)-4,4-diamine, 3,3',5,5'-tetramethyl-

CAS REGISTRY NUMBER :: 54827-17-7

LAST UPDATED :: 199710

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C16-H20-N2

MOLECULAR WEIGHT :: 240.38

WISWESSER LINE NOTATION :: ZR B1 F1 DR DZ C1 E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 135 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: >316 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: Micronucleus test

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - mouse Lymphocyte

DOSE/DURATION :: 30700 ug/L

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 12(Suppl 13),37,1988

Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xi:Irritant
Risk Phrases	R36/37/38
Safety Phrases	S26-S36-S36/37
RIDADR	UN 2796 8/PG 2
WGK Germany	3
RTECS	DV2300000
Hazard Class	8.0
HS Code	29215990

4-CHLORO-2,6-DI...

CAS#:24596-18-7

~93%

Tetramethylbenzidine

CAS#:54827-17-7

Literature: Cheng, Jinsheng; Zhang, Gencheng; Du, Jin; Tang, Longhua; Xu, Jingying; Li, Jinghong Journal of Materials Chemistry, 2011 , vol. 21, # 10 p. 3485 - 3494

4-bromo-2,6-xylidine

CAS#:24596-19-8

~65%

Tetramethylbenzidine

CAS#:54827-17-7

2,6-xylidine

CAS#:87-62-7

Literature: Imperial Chemical Industries Limited Patent: US4022795 A1, 1977 ;

N/A

CAS#:80387-68-4

Tetramethylbenzidine

CAS#:54827-17-7

N/A

CAS#:80387-72-0

2,6-xylidine

CAS#:87-62-7

Literature: Journal of Organic Chemistry, , vol. 47, # 9 p. 1691 - 1696

2,6-dimethyl ph...

CAS#:603-77-0

Tetramethylbenzidine

CAS#:54827-17-7

Literature: Journal of Organic Chemistry, , vol. 47, # 9 p. 1691 - 1696

Precursor 3
CAS#:24596-18-7 4-CHLORO-2,6-DI... CAS#:24596-19-8 4-bromo-2,6-xylidine CAS#:603-77-0 2,6-dimethyl ph...
DownStream 1
CAS#:144653-01-0 2-bromo-5-(4-br...

HS Code	2921590090
Summary	2921590090. other aromatic polyamines and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Evaluation of the immune response and protective efficacy of Schistosoma mansoni Cathepsin B in mice using CpG dinucleotides as adjuvant.

Vaccine 33(2) , 346-53, (2014)

Schistosomiasis is the most important human helminth infection due to its impact on public health. Worldwide, schistosomiasis is estimated to infect at least 200 million individuals while 700 million ...

Gene therapy with AAV2-CDNF provides functional benefits in a rat model of Parkinson's disease.

Brain Behav. 3(2) , 75-88, (2013)

Cerebral dopamine neurotrophic factor (CDNF) protein has been shown to protect the nigrostriatal dopaminergic pathway when given as intrastriatal infusions in rat and mouse models of Parkinson's disea...

MHC class II presentation is controlled by the lysosomal small GTPase, Arl8b.

J. Immunol. 194(5) , 2079-88, (2015)

Dendritic cells (DCs) are specialized APCs with the ability to prime naive T cells. DCs first sample Ags from the environment and then orchestrate their processing and loading onto MHC class II (MHC I...

3355TMB

3,3,5',5'-Tetramethylbenzidine

UNII-3B3T5CB8EO

TMB/H

TMB-E

TMB/M

3,3’,5,5’-tetramethylbenzidine

EINECS 259-364-6

TMB

BM BLUE

3,3',5,5'-Tetramethyl-4,4'-biphenyldiamine

3,3',5,5'-tetramethyl-4,4'-diamino-1,1'-biphenyl

TMB QUICK

3,3',5,5'-tetramethylbenzidine

Tmbz

MFCD00007748

3,3',5,5'-Tetramethylbiphenyl-4,4'-diamine

3,5,3',5'-tetramethylbenzidine

TMB EASY

TMB-B

[1,1'-Biphenyl]-4,4'-diamine, 3,3',5,5'-tetramethyl-

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