15-Hydroxyeicosatetraenoic acid

Modify Date: 2024-01-02 20:39:33

15-Hydroxyeicosatetraenoic acid Structure
15-Hydroxyeicosatetraenoic acid structure
Common Name 15-Hydroxyeicosatetraenoic acid
CAS Number 54845-95-3 Molecular Weight 320.466
Density 1.0±0.1 g/cm3 Boiling Point 487.7±45.0 °C at 760 mmHg
Molecular Formula C20H32O3 Melting Point N/A
MSDS Chinese USA Flash Point 262.8±25.2 °C
Symbol GHS02 GHS07
GHS02, GHS07
Signal Word Danger

 Use of 15-Hydroxyeicosatetraenoic acid


15(S)-HETE is an endogenous metabolite present in Urine that can be used for the research of Zellweger Syndrome[1][2].

 Names

Name 15(s)-hete
Synonym More Synonyms

 15-Hydroxyeicosatetraenoic acid Biological Activity

Description 15(S)-HETE is an endogenous metabolite present in Urine that can be used for the research of Zellweger Syndrome[1][2].
Related Catalog
In Vitro Endogenous metabolites is defined as those that are annotated by Kyoto Encyclopedia of Genes and Genomes as substrates or products of the ~1900 metabolic enzymes encoded in our genome. It is clear in the body of literature that there are documented toxic properties for many of these metabolites[1].
References

[1]. Lee N, et al. Endogenous toxic metabolites and implications in cancer therapy. Oncogene. 2020 Aug;39(35):5709-5720.  

[2]. Mayatepek E, et al. 12- and 15-hydroxyeicosatetraenoic acid are excreted in the urine of peroxisome-deficient patients: evidence for peroxisomal metabolism in vivo. Pediatr Res. 1996 Jan;39(1):146-9.  

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 487.7±45.0 °C at 760 mmHg
Molecular Formula C20H32O3
Molecular Weight 320.466
Flash Point 262.8±25.2 °C
Exact Mass 320.235138
PSA 57.53000
LogP 5.22
Vapour Pressure 0.0±2.8 mmHg at 25°C
Index of Refraction 1.514

 Safety Information

Symbol GHS02 GHS07
GHS02, GHS07
Signal Word Danger
Hazard Statements H225-H315-H319-H335
Precautionary Statements P210-P261-P305 + P351 + P338
Personal Protective Equipment Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes F: Flammable;Xi: Irritant;
Risk Phrases R11
Safety Phrases 7-16-26-36
RIDADR UN 1170 3
HS Code 2918199090

 Synthetic Route

 Customs

HS Code 2918199090
Summary 2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

 Articles56

More Articles
HMDB: a knowledgebase for the human metabolome.

Nucleic Acids Res. 37(Database issue) , D603-10, (2009)

The Human Metabolome Database (HMDB, http://www.hmdb.ca) is a richly annotated resource that is designed to address the broad needs of biochemists, clinical chemists, physicians, medical geneticists, ...

The human serum metabolome.

PLoS ONE 6(2) , e16957, (2011)

Continuing improvements in analytical technology along with an increased interest in performing comprehensive, quantitative metabolic profiling, is leading to increased interest pressures within the m...

Lack of association of ALOX12 and ALOX15B polymorphisms with psoriasis despite altered urinary excretion of 12(S)-hydroxyeicosatetraenoic acid.

Br. J. Dermatol. 172(2) , 337-44, (2015)

Pro- and anti-inflammatory metabolites of arachidonic acid - eicosanoids - participate in skin homeostasis, affecting the growth and differentiation of keratinocytes. Alterations of 12-lipoxygenase (L...

 Synonyms

15(S)-HETE
icomucret
(5Z,8Z,11Z,13E,15S)-15-Hydroxy-5,8,11,13-icosatetraenoic acid
15-HETE
15-Hydroxyeicosatetraenoic acid
5,8,11,13-Eicosatetraenoic acid, 15-hydroxy-, (5Z,8Z,11Z,13E,15S)-
15(S)-Hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoic acid
(5Z,8Z,11Z,13E,15S)-15-hydroxyicosa-5,8,11,13-tetraenoic acid