5502-96-5

5502-96-5 structure
5502-96-5 structure
  • Name: NAADP tetrasodium salt
  • Chemical Name: nicotinic acid-adenine dinucleotide phosphate
  • CAS Number: 5502-96-5
  • Molecular Formula: C21H27N6O18P3
  • Molecular Weight: 744.39
  • Catalog: Research Areas Inflammation/Immunology
  • Create Date: 2017-08-01 19:38:34
  • Modify Date: 2025-08-25 17:44:45
  • NAADP, a nucleotide, is a Ca2+-mobilizing second messenger. NAADP is essential for initiation of Ca2+ signaling[1][2].

Name nicotinic acid-adenine dinucleotide phosphate
Synonyms NAADP tetrasodium salt
Description NAADP, a nucleotide, is a Ca2+-mobilizing second messenger. NAADP is essential for initiation of Ca2+ signaling[1][2].
Related Catalog
In Vitro NAADP tetrasodium (2.5-10 μM) 诱导细胞毒性 T 淋巴细胞中酸性细胞内储存的 Ca2+ 释放[2]。 NAADP tetrasodium (10 μM,30 分钟) 刺激细胞毒性 T 淋巴细胞中的溶细胞颗粒胞吐作用[2]。
In Vivo NAADP (0.181 mg/kg, i.v.) promotes autophagosome formation and protects the hepatocytes from injury in mice induced by LPS/GalN[3]. Animal Model: LPS/GalN induced liver injury mice model[3] Dosage: 3-30 mg/kg Administration: 0.181 mg/kg, i.v. Result: Promoted autophagosome formation in in hepatocytes. Showed higher levels of LC3II, p62, ATG5, and ATG7 in hepatocytes.
References

[1]. Walseth TF, et al: From Discovery to Mechanism. Front Immunol. 2021 Sep 7;12:703326.  

[2]. Davis LC, et al. NAADP activates two-pore channels on T cell cytolytic granules to stimulate exocytosis and killing. Curr Biol. 2012 Dec 18;22(24):2331-7.  

[3]. Rah SY, et al. NAADP-mediated Ca2+ signaling promotes autophagy and protects against LPS-induced liver injury. FASEB J. 2017 Jul;31(7):3126-3137.  

Molecular Formula C21H27N6O18P3
Molecular Weight 744.39
Exact Mass 743.07500
PSA 397.05000
Storage condition 20°C
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi
Risk Phrases 36/37/38
Safety Phrases 26-36
RIDADR NONH for all modes of transport
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.