Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Nicotinicacidadeninedinucleotidephosphatesodiumsalt
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: BETA-NAADP SODIUM SALT
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

5502-96-5

5502-96-5 structure

5502-96-5 structure

Name: NAADP tetrasodium salt
Chemical Name: nicotinic acid-adenine dinucleotide phosphate
CAS Number: 5502-96-5
Molecular Formula: C₂₁H₂₇N₆O₁₈P₃
Molecular Weight: 744.39
Catalog: Research Areas Inflammation/Immunology
Create Date: 2017-08-01 19:38:34
Modify Date: 2024-01-10 19:33:12
NAADP, a nucleotide, is a Ca2+-mobilizing second messenger. NAADP is essential for initiation of Ca2+ signaling[1][2].

Name	nicotinic acid-adenine dinucleotide phosphate
Synonyms	NAADP tetrasodium salt

Description	NAADP, a nucleotide, is a Ca2+-mobilizing second messenger. NAADP is essential for initiation of Ca2+ signaling[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
In Vitro	NAADP tetrasodium (2.5-10 μM) 诱导细胞毒性 T 淋巴细胞中酸性细胞内储存的 Ca2+ 释放[2]。 NAADP tetrasodium (10 μM，30 分钟) 刺激细胞毒性 T 淋巴细胞中的溶细胞颗粒胞吐作用[2]。
In Vivo	NAADP (0.181 mg/kg, i.v.) promotes autophagosome formation and protects the hepatocytes from injury in mice induced by LPS/GalN[3]. Animal Model: LPS/GalN induced liver injury mice model[3] Dosage: 3-30 mg/kg Administration: 0.181 mg/kg, i.v. Result: Promoted autophagosome formation in in hepatocytes. Showed higher levels of LC3II, p62, ATG5, and ATG7 in hepatocytes.
References	[1]. Walseth TF, et al: From Discovery to Mechanism. Front Immunol. 2021 Sep 7;12:703326. [2]. Davis LC, et al. NAADP activates two-pore channels on T cell cytolytic granules to stimulate exocytosis and killing. Curr Biol. 2012 Dec 18;22(24):2331-7. [3]. Rah SY, et al. NAADP-mediated Ca2+ signaling promotes autophagy and protects against LPS-induced liver injury. FASEB J. 2017 Jul;31(7):3126-3137.

Molecular Formula	C₂₁H₂₇N₆O₁₈P₃
Molecular Weight	744.39
Exact Mass	743.07500
PSA	397.05000
Storage condition	20°C

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi
Risk Phrases	36/37/38
Safety Phrases	26-36
RIDADR	NONH for all modes of transport