Uracil-15N2

Modify Date: 2024-01-11 19:49:58

Uracil-15N2 Structure
Uracil-15N2 structure
Common Name Uracil-15N2
CAS Number 5522-55-4 Molecular Weight 114.07400
Density 1.321g/cm3 Boiling Point N/A
Molecular Formula C4H4N2O2 Melting Point >300ºC (dec.)(lit.)
MSDS Chinese USA Flash Point N/A

 Use of Uracil-15N2


Uracil-15N2 is the 15N labeled Uracil[1]. Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA[2].

 Names

Name 1H-1H-pyrimidine-2,4-dione-15N2
Synonym More Synonyms

 Uracil-15N2 Biological Activity

Description Uracil-15N2 is the 15N labeled Uracil[1]. Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA[2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Pałasz A, et al. In search of uracil derivatives as bioactive agents. Uracils and fused uracils: Synthesis, biological activity and applications. Eur J Med Chem. 2015 Jun 5;97:582-611.  

 Chemical & Physical Properties

Density 1.321g/cm3
Melting Point >300ºC (dec.)(lit.)
Molecular Formula C4H4N2O2
Molecular Weight 114.07400
Exact Mass 114.02100
PSA 65.72000
Index of Refraction 1.501

 Safety Information

RIDADR NONH for all modes of transport

 Synthetic Route

~73%

Uracil-15N2 Structure

Uracil-15N2

CAS#:5522-55-4

Literature: LaFrancois, Christopher J.; Fujimoto, June; Sowers, Lawrence C. Chemical Research in Toxicology, 1998 , vol. 11, # 1 p. 75 - 83

 Precursor & DownStream

Precursor  2

DownStream  0

 Synonyms

15N-labeled uracil
Uracil-15N2
15N-enriched uracil
MFCD00075013