5-Hydroxytryptophan

Modify Date: 2026-07-12 22:44:39

5-Hydroxytryptophan Structure
5-Hydroxytryptophan structure
Common Name 5-Hydroxytryptophan
CAS Number 56-69-9 Molecular Weight 220.225
Density 1.5±0.1 g/cm3 Boiling Point 520.6±50.0 °C at 760 mmHg
Molecular Formula C11H12N2O3 Melting Point 298-300ºC
MSDS N/A Flash Point 268.7±30.1 °C

 Use of 5-Hydroxytryptophan


5-Hydroxytryptophan, a tryptophan metabolite, is a direct 5-hydroxytryptamine (5-HT) precursor and an L-aromatic amino acid decarboxylase substrate. [1][2][3].

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name DL-5-Hydroxytryptophan
Synonym More Synonyms

 5-Hydroxytryptophan Biological Activity

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description 5-Hydroxytryptophan, a tryptophan metabolite, is a direct 5-hydroxytryptamine (5-HT) precursor and an L-aromatic amino acid decarboxylase substrate. [1][2][3].
Related Catalog
Target

Human Endogenous Metabolite

References

[1]. Gartside SE, et al. Mediation of ACTH and prolactin responses to 5-HTP by 5-HT2 receptors. Eur J Pharmacol. 1990 Apr 10;179(1-2):103-9.

[2]. Gijsman HJ, et al. Placebo-controlled comparison of three dose-regimens of 5-hydroxytryptophan challenge test in healthy volunteers. J Clin Psychopharmacol. 2002 Apr;22(2):183-9.

[3]. Schruers K, et al. Acute L-5-hydroxytryptophan administration inhibits carbon dioxide-induced panic in panic disorder patients. Psychiatry Res. 2002 Dec 30;113(3):237-43.

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density 1.5±0.1 g/cm3
Boiling Point 520.6±50.0 °C at 760 mmHg
Melting Point 298-300ºC
Molecular Formula C11H12N2O3
Molecular Weight 220.225
Flash Point 268.7±30.1 °C
Exact Mass 220.084793
PSA 99.34000
LogP -0.14
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.737
InChIKey LDCYZAJDBXYCGN-UHFFFAOYSA-N
SMILES NC(Cc1c[nH]c2ccc(O)cc12)C(=O)O
Storage condition 2-8°C

 Toxicological Information

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YN7000000
CHEMICAL NAME :
Tryptophan, 5-hydroxy-
CAS REGISTRY NUMBER :
56-69-9
LAST UPDATED :
199701
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C11-H12-N2-O3
MOLECULAR WEIGHT :
220.25
WISWESSER LINE NOTATION :
T56 BMJ D1YZVQ GQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
30 mg/kg
SEX/DURATION :
male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles)
REFERENCE :
ANENAG Annales d'Endocrinologie. (Masson Editeur, 120 Blvd. Saint-Germain, F-25280 Paris Cedex 06, France) V.1- 1939- Volume(issue)/page/year: 24(Suppl 3),1,1963 *** REVIEWS *** TOXICOLOGY REVIEW CLPTAT Clinical Pharmacology and Therapeutics (St. Louis). (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1960- Volume(issue)/page/year: 5,480,1964

 Safety Information

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Hazard Codes Xn
Risk Phrases 22-36/37/38-65-20/21/22-20/21
Safety Phrases 24/25-22
RIDADR UN 2811
WGK Germany 3.0
RTECS YN7100000
Packaging Group III
HS Code 2929909090

 Customs

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code 2929909090
Summary 2929909090 other compounds with other nitrogen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

MFCD00005651
5-HYDROXY-TRYPTOPHAN
5-Hydroxytryptophan DL-form
DL-5-HTP
2-Chloro-3-methylamine-5-trifluoromethylpyridine hydrochloride
EINECS 200-284-8
(±)-5-hydroxytryptophan
5-Hydroxytryptophan
5-Hydroxy Tryptophan
Dl-5-Hydroxytryptophan

 5-Hydroxytryptophan | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the polar surface area (PSA) of DL-5-Hydroxytryptophan?
A: Polar surface area (PSA) of DL-5-Hydroxytryptophan is 99.34000.
Q: What is the boiling point of DL-5-Hydroxytryptophan?
A: Boiling point of DL-5-Hydroxytryptophan is 520.6±50.0 °C at 760 mmHg.
Q: What English synonyms does DL-5-Hydroxytryptophan have?
A: English synonyms of DL-5-Hydroxytryptophan: MFCD00005651, 5-HYDROXY-TRYPTOPHAN, 5-Hydroxytryptophan DL-form, DL-5-HTP, 2-Chloro-3-methylamine-5-trifluoromethylpyridine hydrochloride, EINECS 200-284-8, (±)-5-hydroxytryptophan, 5-Hydroxytryptophan, 5-Hydroxy Tryptophan, Dl-5-Hydroxytryptophan.
Q: What are the uses of DL-5-Hydroxytryptophan?
A: Main uses of DL-5-Hydroxytryptophan: 5-Hydroxytryptophan, a tryptophan metabolite, is a direct 5-hydroxytryptamine (5-HT) precursor and an L-aromatic amino acid decarboxylase substrate. [1][2][3].
Q: What are the downstream products of DL-5-Hydroxytryptophan?
A: Related downstream products(CAS) of DL-5-Hydroxytryptophan: 50-67-9;150-76-5;108-46-3;100-22-1;619-60-3.
Q: What is the melting point of DL-5-Hydroxytryptophan?
A: Melting point of DL-5-Hydroxytryptophan is 298-300ºC.
Q: What are the storage conditions for DL-5-Hydroxytryptophan?
A: Storage conditions for DL-5-Hydroxytryptophan: 2-8°C.
Q: What is the molecular formula of DL-5-Hydroxytryptophan?
A: Molecular formula of DL-5-Hydroxytryptophan is C11H12N2O3.
Q: What is the safety information for DL-5-Hydroxytryptophan?
A: Safety information for DL-5-Hydroxytryptophan: 24/25-22.
Q: What is the SMILES notation of DL-5-Hydroxytryptophan?
A: SMILES notation of DL-5-Hydroxytryptophan is NC(Cc1c[nH]c2ccc(O)cc12)C(=O)O.

 5-Hydroxytryptophanfactory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd
Henan Tianfu Chemical Co., Ltd.
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