Histamine

Modify Date: 2024-01-02 09:59:41

Histamine structure	Common Name	Histamine
	CAS Number	51-45-6	Molecular Weight	111.145
	Density	1.1±0.1 g/cm3	Boiling Point	331.0±17.0 °C at 760 mmHg
	Molecular Formula	C₅H₉N₃	Melting Point	83-84ºC
	MSDS	Chinese USA	Flash Point	180.3±8.1 °C
	Symbol	GHS06, GHS08	Signal Word	Danger

Use of Histamine

Histamine is an organic nitrogenous compound involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter.

Name	histamine
Synonym	More Synonyms

Description	Histamine is an organic nitrogenous compound involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Neurological Disease Natural Products >> Others
Target	Human Endogenous Metabolite

Density	1.1±0.1 g/cm3
Boiling Point	331.0±17.0 °C at 760 mmHg
Melting Point	83-84ºC
Molecular Formula	C₅H₉N₃
Molecular Weight	111.145
Flash Point	180.3±8.1 °C
Exact Mass	111.079643
PSA	54.70000
LogP	-0.92
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.567
Storage condition	−20°C

Histamine MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MS1050000

CHEMICAL NAME :: Histamine

CAS REGISTRY NUMBER :: 51-45-6

LAST UPDATED :: 199710

DATA ITEMS CITED :: 25

MOLECULAR FORMULA :: C5-H9-N3

MOLECULAR WEIGHT :: 111.17

WISWESSER LINE NOTATION :: T5M CNJ D2Z

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 630 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 220 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 725 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2500 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 385 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 28500 ug/kg

TOXIC EFFECTS :: Behavioral - coma Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 7 mg/kg

TOXIC EFFECTS :: Cardiac - other changes

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 34 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 12 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Cardiac - pulse rate increase, without fall in BP Lungs, Thorax, or Respiration - respiratory stimulation

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 5 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 8 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 180 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 1700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 200 mg/kg

SEX/DURATION :: male 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - mouse Embryo

DOSE/DURATION :: 200 mg/L

REFERENCE :: DANKAS Doklady Akademii Nauk SSSR. Proceedings of the Academy of Sciences of the USSR. For English translation, see DBIOAM and DKBSAS. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1933- Volume(issue)/page/year: 282,173,1985 *** REVIEWS *** TOXICOLOGY REVIEW NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928- Volume(issue)/page/year: 294,30,1976 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4896 No. of Facilities: 38 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 915 (estimated) No. of Female Employees: 721 (estimated)

Symbol	GHS06, GHS08
Signal Word	Danger
Hazard Statements	H301-H315-H317-H319-H334-H335
Precautionary Statements	P261-P280-P301 + P310-P305 + P351 + P338-P342 + P311
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xn:Harmful;
Risk Phrases	R22;R36/37/38;R42/43
Safety Phrases	S22-S26-S36/37
RIDADR	UN 2811
WGK Germany	3
RTECS	MS1050000
Packaging Group	III
Hazard Class	6.1(b)
HS Code	2933290090

Precursor 9
CAS#:71-00-1 L-Histidine CAS#:66348-61-6 monocloridrato ... CAS#:13518-55-3 4-(2-CHLOROETHY... CAS#:18502-05-1 2-(1H-IMIDAZOL-...
CAS#:56-92-8 Histamine dihyd... CAS#:5354-94-9 N-Benzoylhistidine CAS#:7647-01-0 Hydrochloric acid CAS#:7664-93-9 Sulfuric acid
CAS#:50-81-7 Ascorbic acid
DownStream 10
CAS#:56897-53-1 Carcinine hydro... CAS#:149298-61-3 N-[2-(1H-imidaz... CAS#:18431-51-1 N(alpha)-guanil... CAS#:23100-08-5 dolichotheline
CAS#:6882-74-2 Spinaceamine CAS#:673-49-4 N-ω-Acetylhistamine CAS#:103692-68-8 N-[2-(1H-imidaz... CAS#:14509-66-1 imidazo-[1,5-c]...
CAS#:107-95-9 beta-Alanine CAS#:374081-26-2 2,2-DIPHENYLETH...

HS Code	2933290090
Summary	2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Clonal differences in IgE antibodies affect cutaneous anaphylaxis-associated thermal sensitivity in mice.

Immunol. Lett. 162(1 Pt A) , 149-58, (2014)

Cellular and molecular mediators of immune responses are increasingly implicated in acute and chronic pain pathophysiologies. Here we demonstrate that passive cutaneous IgE/Ag anaphylaxis provokes inc...

Histamine inhibits differentiation of skin fibroblasts into myofibroblasts.

Biochem. Biophys. Res. Commun. 463 , 434-9, (2015)

Histamine and TGF-β, major mediators secreted by mast cells, are involved in skin inflammation and play critical roles in the pathogenesis of systemic sclerosis. However, the roles of signaling mechan...

Inhibition of TRPM7 channels reduces degranulation and release of cytokines in rat bone marrow-derived mast cells.

Int. J. Mol. Sci. 15(7) , 11817-31, (2014)

mast cells play an important role in airway inflammation in asthma. The transient receptor potential melastatin-like 7 (TRPM7) channel is expressed in primary human lung mast cells and plays a critica...

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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Histamine
Price: ￥458.0/1g ￥98.0/20mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Liu jia

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Histamine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Histamine 51-45-6
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Histamine

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