Ionomycin calcium salt

Modify Date: 2024-01-05 04:43:07

Ionomycin calcium salt structure	Common Name	Ionomycin calcium salt
	CAS Number	56092-82-1	Molecular Weight	747.067
	Density	N/A	Boiling Point	817.2ºC at 760mmHg
	Molecular Formula	C₄₁H₇₀CaO₉	Melting Point	205-206ºC
	MSDS	Chinese USA	Flash Point	235.2ºC
	Symbol	GHS07	Signal Word	Warning

Use of Ionomycin calcium salt

Ionomycin (calcium) is a Calcium ionophore and an antibiotic produced by Streptomyces conglobatus.

Name	Ionomycin calcium salt from Streptomyces conglobatus
Synonym	More Synonyms

Description	Ionomycin (calcium) is a Calcium ionophore and an antibiotic produced by Streptomyces conglobatus.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Cancer Research Areas >> Infection
Target	Calcium channel[1].
In Vitro	Ionomycin is a Calcium ionophore and an antibiotic produced by Streptomyces conglobatus[1]. Addition of 2 μM Ionomycin to LCLC 103H cells causes an instantaneous increase in intracellular Ca2+ concentration from 50 to 180 nM. DNA and protein analysis in Ionomycin-treated cultures revealed DNA fragmentation and PARP cleavage to an 85-kDa fragment typical of caspase-mediated apoptosis. Necrosis could be detected in ~1-5% of the Ionomycin treated cells as supported by simultaneously positive fluorescein labeling and propidium iodide uptake. Caspase activation in whole cells was followed by monitoring the increase in activity against Ac-DEVD-amc following Ionomycin treatment[2].
References	[1]. Liu C, et al. Characterization of ionomycin as a calcium ionophore. J Biol Chem. 1978 Sep 10;253(17):5892-4. [2]. Gil-Parrado S, et al. Ionomycin-activated calpain triggers apoptosis. A probable role for Bcl-2 family members. J Biol Chem. 2002 Jul 26;277(30):27217-26.

Boiling Point	817.2ºC at 760mmHg
Melting Point	205-206ºC
Molecular Formula	C₄₁H₇₀CaO₉
Molecular Weight	747.067
Flash Point	235.2ºC
Exact Mass	746.464600
PSA	131.75000
LogP	7.64540
Storage condition	2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NO0650000

CHEMICAL NAME :: Ionomycin, calcium salt

CAS REGISTRY NUMBER :: 56092-82-1

LAST UPDATED :: 199106

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C41-H70-O9.Ca

MOLECULAR WEIGHT :: 747.19

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 650 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 37ASAA "Kirk-Othmer Encyclopedia of Chemical Technology," 3rd ed., Grayson, M., and D. Eckroth, eds., New York, John Wiley & Sons, Inc., 1978 Volume(issue)/page/year: 3,47,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 12 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 37ASAA "Kirk-Othmer Encyclopedia of Chemical Technology," 3rd ed., Grayson, M., and D. Eckroth, eds., New York, John Wiley & Sons, Inc., 1978 Volume(issue)/page/year: 3,47,1978

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn
Risk Phrases	22
Safety Phrases	36
RIDADR	NONH for all modes of transport
RTECS	NO0650000

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Ionomycin calcium salt

10,16-Docosadienoic acid, 11,19,21-trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-[(2S,2'R,5S,5'S)-octahydro-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyl[2,2'-bifuran]-5-yl]-9-oxo-, calcium salt, (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)- (1:1)

MFCD00151183

Calcium (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-19,21-dihydroxy-22-{(2S,2'R,5S,5'S)-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyloctahydro-2,2'-bifuran-5-yl}-4,6,8,12,14,18,20-heptamethyl-11-oxido-9-oxo-10,16-docosadienoate