(Pyr5)-Substance P (5-11) structure
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Common Name | (Pyr5)-Substance P (5-11) | ||
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CAS Number | 56104-22-4 | Molecular Weight | 852.011 | |
Density | 1.3±0.1 g/cm3 | Boiling Point | 1374.9±65.0 °C at 760 mmHg | |
Molecular Formula | C41H57N9O9S | Melting Point | N/A | |
MSDS | Chinese USA | Flash Point | 785.3±34.3 °C |
Use of (Pyr5)-Substance P (5-11)[Glp5] Substance P (5-11) is an octapeptide. [Glp5] Substance P (5-11) is one of the main substance P fragments in rat central nervous system (CNS). [Glp5] Substance P (5-11) locally modulates dopamine release in rat striatum[1]. |
Name | N-[1-[[1-[[2-[[1-[(1-amino-4-methylsulfanyl-1-oxobutan-2-yl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-2-[(5-oxopyrrolidine-2-carbonyl)amino]pentanediamide |
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Synonym | More Synonyms |
Description | [Glp5] Substance P (5-11) is an octapeptide. [Glp5] Substance P (5-11) is one of the main substance P fragments in rat central nervous system (CNS). [Glp5] Substance P (5-11) locally modulates dopamine release in rat striatum[1]. |
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Related Catalog | |
In Vitro | [Glp5] Substance P (5-11) (0.12 nM-10 μM; rat striatum) modifies spontaneous dopamine outflow with a significant increase in dopamine outflow at 0.1 nM and a smaller effect at 1 nM, whereas concentrations lower than 0.1 nM or higher than 1 nM failed to modify dopamine release. [Glp5] Substance P (5-11) and K+ has additive effect, promoting the release of dopamine[1]. |
References |
Density | 1.3±0.1 g/cm3 |
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Boiling Point | 1374.9±65.0 °C at 760 mmHg |
Molecular Formula | C41H57N9O9S |
Molecular Weight | 852.011 |
Flash Point | 785.3±34.3 °C |
Exact Mass | 851.400024 |
PSA | 315.18000 |
LogP | 0.64 |
Vapour Pressure | 0.0±0.3 mmHg at 25°C |
Index of Refraction | 1.581 |
Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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RIDADR | NONH for all modes of transport |
Biological activity of C-terminal partial sequences of substance P.
J. Med. Chem. 19 , 854, (1976) Substance P (Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2) and the C-terminal partial sequences down to the tripeptide were synthesized by a solid-phase method. These peptides were assayed for vaso... |
5-Oxo-L-prolyl-L-glutaminyl-L-phenylalanyl-L-phenylalanylglycyl-L-leucyl-L-methioninamide |
[pGlu5]-Substance P Fragment 5-11 |
pGlu-Gln-Phe-Phe-Gly-Leu-Met-NH2 |
L-Methioninamide, 5-oxo-L-prolyl-L-glutaminyl-L-phenylalanyl-L-phenylalanylglycyl-L-leucyl- |