(Pyr5)-Substance P (5-11)

Modify Date: 2024-01-08 18:21:28

(Pyr5)-Substance P (5-11) Structure
(Pyr5)-Substance P (5-11) structure
Common Name (Pyr5)-Substance P (5-11)
CAS Number 56104-22-4 Molecular Weight 852.011
Density 1.3±0.1 g/cm3 Boiling Point 1374.9±65.0 °C at 760 mmHg
Molecular Formula C41H57N9O9S Melting Point N/A
MSDS Chinese USA Flash Point 785.3±34.3 °C

 Use of (Pyr5)-Substance P (5-11)


[Glp5] Substance P (5-11) is an octapeptide. [Glp5] Substance P (5-11) is one of the main substance P fragments in rat central nervous system (CNS). [Glp5] Substance P (5-11) locally modulates dopamine release in rat striatum[1].

 Names

Name N-[1-[[1-[[2-[[1-[(1-amino-4-methylsulfanyl-1-oxobutan-2-yl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-2-[(5-oxopyrrolidine-2-carbonyl)amino]pentanediamide
Synonym More Synonyms

 (Pyr5)-Substance P (5-11) Biological Activity

Description [Glp5] Substance P (5-11) is an octapeptide. [Glp5] Substance P (5-11) is one of the main substance P fragments in rat central nervous system (CNS). [Glp5] Substance P (5-11) locally modulates dopamine release in rat striatum[1].
Related Catalog
In Vitro [Glp5] Substance P (5-11) (0.12 nM-10 μM; rat striatum) modifies spontaneous dopamine outflow with a significant increase in dopamine outflow at 0.1 nM and a smaller effect at 1 nM, whereas concentrations lower than 0.1 nM or higher than 1 nM failed to modify dopamine release. [Glp5] Substance P (5-11) and K+ has additive effect, promoting the release of dopamine[1].
References

[1]. Khan S, et, al. Substance P-(1-7) and substance P-(5-11) locally modulate dopamine release in rat striatum. Eur J Pharmacol. 1995 Aug 25;282(1-3):229-33.  

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 1374.9±65.0 °C at 760 mmHg
Molecular Formula C41H57N9O9S
Molecular Weight 852.011
Flash Point 785.3±34.3 °C
Exact Mass 851.400024
PSA 315.18000
LogP 0.64
Vapour Pressure 0.0±0.3 mmHg at 25°C
Index of Refraction 1.581

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport

 Articles1

More Articles
Biological activity of C-terminal partial sequences of substance P.

J. Med. Chem. 19 , 854, (1976)

Substance P (Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2) and the C-terminal partial sequences down to the tripeptide were synthesized by a solid-phase method. These peptides were assayed for vaso...

 Synonyms

5-Oxo-L-prolyl-L-glutaminyl-L-phenylalanyl-L-phenylalanylglycyl-L-leucyl-L-methioninamide
[pGlu5]-Substance P Fragment 5-11
pGlu-Gln-Phe-Phe-Gly-Leu-Met-NH2
L-Methioninamide, 5-oxo-L-prolyl-L-glutaminyl-L-phenylalanyl-L-phenylalanylglycyl-L-leucyl-
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