L-Phenylalanine-d5

Modify Date: 2024-01-10 21:32:20

L-Phenylalanine-d5 Structure
L-Phenylalanine-d5 structure
Common Name L-Phenylalanine-d5
CAS Number 56253-90-8 Molecular Weight 170.220
Density 1.2±0.1 g/cm3 Boiling Point 307.5±30.0 °C at 760 mmHg
Molecular Formula C9H6D5NO2 Melting Point 270-275 °C (dec. )(lit.)
MSDS USA Flash Point 139.8±24.6 °C

 Use of L-Phenylalanine-d5


L-Phenylalanine-d5 is the deuterium labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].

 Names

Name phenylalanine-d5
Synonym More Synonyms

 L-Phenylalanine-d5 Biological Activity

Description L-Phenylalanine-d5 is the deuterium labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 307.5±30.0 °C at 760 mmHg
Melting Point 270-275 °C (dec. )(lit.)
Molecular Formula C9H6D5NO2
Molecular Weight 170.220
Flash Point 139.8±24.6 °C
Exact Mass 170.110367
PSA 63.32000
LogP 1.11
Vapour Pressure 0.0±0.7 mmHg at 25°C
Index of Refraction 1.576
Storage condition 2-8°C

 Safety Information

WGK Germany 3

 Synonyms

(2,3,4,5,6-H)Phenylalanine
L-Phenylalanine-d5
Phenylalanine-2,3,4,5,6-d
L-Phenyl-D5-alanine
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