Aloperine
Aloperine structure
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Common Name | Aloperine | ||
|---|---|---|---|---|
| CAS Number | 56293-29-9 | Molecular Weight | 232.365 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 367.7±37.0 °C at 760 mmHg | |
| Molecular Formula | C15H24N2 | Melting Point | 69 - 71ºC | |
| MSDS | Chinese USA | Flash Point | 155.8±17.5 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of AloperineAloperine is an alkaloid in sophora plants such as Sophora alopecuroides L, which has shown anti-cancer, anti-inflammatory and anti-virus properties[1]. Aloperine is widely used to treat patients with allergic contact dermatitis eczema and other skin inflammation in China[2]. Aloperine induces apoptosis and autophagy in HL-60 cells[1]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | aloperine |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Aloperine is an alkaloid in sophora plants such as Sophora alopecuroides L, which has shown anti-cancer, anti-inflammatory and anti-virus properties[1]. Aloperine is widely used to treat patients with allergic contact dermatitis eczema and other skin inflammation in China[2]. Aloperine induces apoptosis and autophagy in HL-60 cells[1]. |
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| Related Catalog | |
| In Vitro | Aloperine (1-20 mM; 24 hours) gives growth-inhibitory IC50 values in cancer cells ranges from 0.04 to 1.36 mM, the IC50 values in HL-60, U937, K562, EC109, A549 and HepG2 cells are 0.04, 0.27, 0.36, 1.11, 1.18 and 1.36 mM,respectively[1]. Aloperine (1-20 mM; 24 hours) induces apoptosis and decreases bcl-2 expression in HL-60 cells[1]. Aloperine (20–100 mM; 18 hours) induces autophagy and formation of acidic vacuole in HL-60 cells[1]. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 367.7±37.0 °C at 760 mmHg |
| Melting Point | 69 - 71ºC |
| Molecular Formula | C15H24N2 |
| Molecular Weight | 232.365 |
| Flash Point | 155.8±17.5 °C |
| Exact Mass | 232.193954 |
| PSA | 15.27000 |
| LogP | 3.21 |
| Vapour Pressure | 0.0±0.8 mmHg at 25°C |
| Index of Refraction | 1.583 |
| InChIKey | SKOLRLSBMUGVOY-GBJTYRQASA-N |
| SMILES | C1=C2CCCNC2C2CC1C1CCCCN1C2 |
| Storage condition | -20℃ |
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
| Hazard Codes | Xn |
| Risk Phrases | R22 |
| RIDADR | NONH for all modes of transport |
| RTECS | RM2979500 |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 4 | |
|---|---|
| DownStream 0 | |
CAS#:220384-56-5![(6R,7R,13R,14R,15S)-14-hydroxy-1-(p-toluenesulfonyl)-tetradecahydro-6,13-methano-dipyrido[1,2-a,3',2'-e]azocin-12-one Structure](https://image.chemsrc.com/caspic/098/220384-61-2.png)
CAS#:220384-61-2
CAS#:792937-20-3
CAS#:792937-19-0This table lists relevant public references with title, journal and publication metadata for this compound.
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Two Small Molecules Block Oral Epithelial Cell Invasion by Porphyromons gingivalis.
PLoS ONE 11 , e0149618, (2016) Porphyromonas gingivalis is a keystone pathogen of periodontitis. One of its bacterial characteristics is the ability to invade various host cells, including nonphagocytic epithelial cells and fibrobl... |
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Aloperine executes antitumor effects against multiple myeloma through dual apoptotic mechanisms.
J. Hematol. Oncol. 8 , 26, (2015) Aloperine, a natural alkaloid constituent isolated from the herb Sophora alopecuroides displays anti-inflammatory properties in vitro and in vivo. Our group previously demonstrated that aloperine sign... |
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[Simultaneous determination of 7 alkaloid in herba Sophorae Alopecuroidis by HPLC].
Zhongguo Zhong Yao Za Zhi 36(11) , 1483-6, (2011) To establish a method for determination of 7 alkaloid in Herba Sophorae Alopecuroidis by HPLC.X-Brige C18 (4.6 mm x 200 mm, 5 microm) column was used with acetonitriles-0.05 mol x L(-1) KH2PO4 solutio... |
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| ALOPERIN |
| ALLOPTERIN |
| Aloperine,orMosanine |
| (1R,2S,9R,10R)-3,15-Diazatetracyclo[7.7.1.0.0]heptadec-7-ene |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What are the upstream materials of aloperine? |
| A: Related upstream materials(CAS) of aloperine: 220384-56-5;220384-61-2;792937-20-3;792937-19-0. |
| Q: What are the uses of aloperine? |
| A: Main uses of aloperine: Aloperine is an alkaloid in sophora plants such as Sophora alopecuroides L, which has shown anti-cancer, anti-inflammatory and anti-virus properties[1]. Aloperine is widely used to treat patients with allergic contact dermatitis eczema and other skin inflammation in China[2]. Aloperine induces apoptosis and autophagy in HL-60 cells[1]. |
| Q: What is the melting point of aloperine? |
| A: Melting point of aloperine is 69 - 71ºC. |
| Q: What is the molecular formula of aloperine? |
| A: Molecular formula of aloperine is C15H24N2. |
| Q: What is the boiling point of aloperine? |
| A: Boiling point of aloperine is 367.7±37.0 °C at 760 mmHg. |
| Q: What is the molecular weight of aloperine? |
| A: Molecular weight of aloperine is 232.365. |
| Q: What is the polar surface area (PSA) of aloperine? |
| A: Polar surface area (PSA) of aloperine is 15.27000. |
| Q: What is the English name of aloperine? |
| A: The English name of aloperine is aloperine. |
| Q: What is the InChIKey of aloperine? |
| A: InChIKey of aloperine is SKOLRLSBMUGVOY-GBJTYRQASA-N. |
| Q: What is the SMILES notation of aloperine? |
| A: SMILES notation of aloperine is C1=C2CCCNC2C2CC1C1CCCCN1C2. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| BioBioPha |
| naturewill |