Diacetyl monoxime

Modify Date: 2024-01-08 11:41:44

Diacetyl monoxime structure	Common Name	Diacetyl monoxime
	CAS Number	57-71-6	Molecular Weight	101.104
	Density	1.1±0.1 g/cm3	Boiling Point	185.5±9.0 °C at 760 mmHg
	Molecular Formula	C₄H₇NO₂	Melting Point	75-78 °C(lit.)
	MSDS	USA	Flash Point	66.0±18.7 °C

Use of Diacetyl monoxime

Biacetyl monoxime (Diacetyl monoxime), a myosin ATPase inhibitor, is a skeletal and cardiac muscle contraction inhibitor. Biacetyl monoxime induces sarcoplasmic reticulum Ca2+ release[1][2].

Name	Diacetylmonoxime
Synonym	More Synonyms

Description	Biacetyl monoxime (Diacetyl monoxime), a myosin ATPase inhibitor, is a skeletal and cardiac muscle contraction inhibitor. Biacetyl monoxime induces sarcoplasmic reticulum Ca2+ release[1][2].
Related Catalog	Research Areas >> Metabolic Disease
References	[1]. Kohsuke Hashimoto, et al. The myosin ATPase inhibitor, 2,3-butanedione 2-monoxime, prevents protein secretion by the basidiomycete Coprinopsis cinerea. Biotechnol Lett. 2011 Apr;33(4):769-75. [2]. R M Phillips, et al. 2,3-Butanedione 2-monoxime (BDM) induces calcium release from canine cardiac sarcoplasmic reticulum. Biochem Biophys Res Commun. 1996 Dec 4;229(1):154-7.

Description

Biacetyl monoxime (Diacetyl monoxime), a myosin ATPase inhibitor, is a skeletal and cardiac muscle contraction inhibitor. Biacetyl monoxime induces sarcoplasmic reticulum Ca2+ release[1][2].

Related Catalog

Research Areas >> Metabolic Disease

References

[1]. Kohsuke Hashimoto, et al. The myosin ATPase inhibitor, 2,3-butanedione 2-monoxime, prevents protein secretion by the basidiomycete Coprinopsis cinerea. Biotechnol Lett. 2011 Apr;33(4):769-75.

[2]. R M Phillips, et al. 2,3-Butanedione 2-monoxime (BDM) induces calcium release from canine cardiac sarcoplasmic reticulum. Biochem Biophys Res Commun. 1996 Dec 4;229(1):154-7.

Density	1.1±0.1 g/cm3
Boiling Point	185.5±9.0 °C at 760 mmHg
Melting Point	75-78 °C(lit.)
Molecular Formula	C₄H₇NO₂
Molecular Weight	101.104
Flash Point	66.0±18.7 °C
Exact Mass	101.047676
PSA	49.66000
LogP	-0.47
Vapour Pressure	0.3±0.7 mmHg at 25°C
Index of Refraction	1.452
Stability	Stable. Incompatible with strong oxidizing agents.
Water Solubility	5 g/100 mL (20 ºC)

Diacetyl monoxime MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EK3150000

CHEMICAL NAME :: 2,3-Butanedione, monooxime

CAS REGISTRY NUMBER :: 57-71-6

BEILSTEIN REFERENCE NO. :: 0605582

LAST UPDATED :: 199701

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C4-H7-N-O2

MOLECULAR WEIGHT :: 101.12

WISWESSER LINE NOTATION :: QNUY1&V1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 51 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 53,1143,1964 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6850 mg/kg/23D-I

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Gastrointestinal - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 119,522,1957 *** REVIEWS *** TOXICOLOGY REVIEW JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 53,1143,1964 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0440 No. of Facilities: 718 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 4820 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0440 No. of Facilities: 370 (estimated) No. of Industries: 2 No. of Occupations: 5 No. of Employees: 1974 (estimated) No. of Female Employees: 1730 (estimated)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xn:Harmful
Risk Phrases	R20/21/22;R36/37/38
Safety Phrases	S22-S24/25-S36/37/39-S26
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	EK3150000
HS Code	29280090

Precursor 2
CAS#:78-93-3 2-Butanone CAS#:110-46-3 Isopentyl nitrite
DownStream 5
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CAS#:6116-75-2 2,3-DIMETHYL-6,...

HS Code	2928000090
Summary	2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

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2,3-Butanedione, monooxime, (2E)-

(3E)-3-(Hydroxyimino)-2-butanone

EINECS 200-348-5

2,3-BUTANEDIONE-2-OXIME

Diacetyl monoxime

(2E)-butane-2,3-dione oxime

(3E)-3-(Hydroxyimino)butan-2-one

MFCD00002116

2,3-Butanedione monoxime

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Diacetyl monoxime
Price: ￥398.0/100g ￥138.0/25g
Purity: 98.0%
Stocking Period: Inquiry
Contact: Liu jia

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2,3-Butanedione monoxime
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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