7-Methylguanine

Modify Date: 2025-08-25 12:26:34

7-Methylguanine Structure
7-Methylguanine structure
 Common Name 7-Methylguanine
CAS Number 578-76-7 Molecular Weight 165.153
Density 1.8±0.1 g/cm3 Boiling Point 481.4±37.0 °C at 760 mmHg
Molecular Formula C6H7N5O Melting Point 370°C
MSDS N/A Flash Point 244.9±26.5 °C

 Use of 7-Methylguanine


7-Methylguanine is a metabolite of DNA methylation. It can be generated by methylating agents, and used as a probe of protein–DNA interactions and a key component of DNA sequencing method.

 Names

Name 2-amino-7-methyl-1,7-dihydro-6H-purin-6-one
Synonym More Synonyms

 7-Methylguanine Biological Activity

Description 7-Methylguanine is a metabolite of DNA methylation. It can be generated by methylating agents, and used as a probe of protein–DNA interactions and a key component of DNA sequencing method.
Related Catalog
Target

Human Endogenous Metabolite

References

[1]. Lee S, et al. Synthesis and structure of duplex DNA containing the genotoxic nucleobase lesion N7-methylguanine. J Am Chem Soc. 2008 Sep 3;130(35):11570-1.

 Chemical & Physical Properties

Density 1.8±0.1 g/cm3
Boiling Point 481.4±37.0 °C at 760 mmHg
Melting Point 370°C
Molecular Formula C6H7N5O
Molecular Weight 165.153
Flash Point 244.9±26.5 °C
Exact Mass 165.065063
PSA 89.59000
LogP -2.08
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.865
Storage condition −20°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MF8464000
CHEMICAL NAME :
Guanine, 7-methyl-
CAS REGISTRY NUMBER :
578-76-7
LAST UPDATED :
199206
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C6-H7-N5-O
MOLECULAR WEIGHT :
165.18

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
Phage inhibition capacity
TEST SYSTEM :
Bacteria - Escherichia coli
DOSE/DURATION :
1 gm/L
REFERENCE :
ZAPOAK Zeitschrift fuer Allgemeine Mikrobiologie. (Akademie-Verlag GmbH, Postfach 1233, Berlin DDR-1086 Ger. Dem. Rep.) V.1- 1960- Volume(issue)/page/year: 12,583,1972

 Safety Information

Hazard Codes Xi
WGK Germany 3
RTECS MF8464000

 Synthetic Route

 Synonyms

6H-Purin-6-one, 2-amino-1,7-dihydro-7-methyl-
2-amino-7-methyl-3H-purin-6-one
2-Amino-7-methyl-1,7-dihydro-6H-purin-6-one
7-methyl-Guanine (8CI)
7-N-methylguanine
N(sup 7)-Methylguanine
7-methyl-Guanine
Epiguanine
2-Amino-7-methylhypoxanthine
N7-Methylguanine
7-Methylguanine
2-amino-7-methyl-1,7-dihydro-purin-6-one
2-Amino-1,7-dihydro-7-methyl-6H-purin-6-one
GUANINE,7-METHYL
2-Amino-6-hydroxy-7-methylpurine
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Chemsrc provides 7-Methylguanine(CAS#:578-76-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of 7-Methylguanine are included as well.>> amp version: 7-Methylguanine

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