Perphenazine structure
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Common Name | Perphenazine | ||
|---|---|---|---|---|
| CAS Number | 58-39-9 | Molecular Weight | 403.969 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 580.4±50.0 °C at 760 mmHg | |
| Molecular Formula | C21H26ClN3OS | Melting Point | 35339ºC | |
| MSDS | USA | Flash Point | 304.8±30.1 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of PerphenazinePerphenazine is a typical antipsychotic drug, inhibits 5-HT2Areceptor, Alpha-1A adrenergic receptor, Dopamine receptor D2/D3, D2L receptor, and Histamine H1 receptor, with Ki values of 5.6, 10, 0.765/0.13, 3.4, and 8 nM, respectively. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | perphenazine |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Perphenazine is a typical antipsychotic drug, inhibits 5-HT2Areceptor, Alpha-1A adrenergic receptor, Dopamine receptor D2/D3, D2L receptor, and Histamine H1 receptor, with Ki values of 5.6, 10, 0.765/0.13, 3.4, and 8 nM, respectively. |
|---|---|
| Related Catalog | |
| Target |
5-HT2A Receptor:5.6 nM (Ki) H1 receptor:8 nM (Ki) α1A adrenergic receptor:10 nM (Ki) D2 receptor:0.765 nM (Ki) D3 receptor:0.13 nM (Ki) D2L receptor:3.4 nM (Ki) |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 580.4±50.0 °C at 760 mmHg |
| Melting Point | 35339ºC |
| Molecular Formula | C21H26ClN3OS |
| Molecular Weight | 403.969 |
| Flash Point | 304.8±30.1 °C |
| Exact Mass | 403.148499 |
| PSA | 55.25000 |
| LogP | 4.34 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.627 |
| InChIKey | RGCVKNLCSQQDEP-UHFFFAOYSA-N |
| SMILES | OCCN1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1 |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H317 |
| Precautionary Statements | P280-P301 + P312 + P330 |
| Hazard Codes | Xn |
| Risk Phrases | R22 |
| Safety Phrases | 28-36/37/39-45 |
| RIDADR | UN 2811 6.1 / PGII |
| WGK Germany | 3 |
| RTECS | TL7175000 |
| HS Code | 2934999090 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
|
~%
Perphenazine CAS#:58-39-9 |
| Literature: US2838507 , ; US2766235 , ; |
|
~%
Perphenazine CAS#:58-39-9 |
| Literature: US2860138 , ; |
|
~%
Perphenazine CAS#:58-39-9 |
| Literature: US2766235 , ; |
|
~%
Perphenazine CAS#:58-39-9 |
| Literature: US2860138 , ; |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 5 | |
|---|---|
| DownStream 3 | |
This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2934999090 |
|---|---|
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
This table lists relevant public references with title, journal and publication metadata for this compound.
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Simultaneous determination of β-agonists and psychiatric drugs in feeds by LC-MS-MS.
J. Chromatogr. Sci. 52(7) , 604-8, (2014) A method was developed for the simultaneous determination of nine β-agonists (cimaterol, ractopamine, terbutaline, zilpaterol, salbutamol, clenbuterol, mabuterol, bambuterol and brombuterol) and six p... |
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Salt effects in electromembrane extraction.
J. Chromatogr. A. 1347 , 1-7, (2014) Electromembrane extraction (EME) was performed on samples containing substantial amounts of NaCl to investigate how the presence of salts affected the recovery, repeatability, and membrane current in ... |
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Simple and sensitive screening and quantitative determination of 88 psychoactive drugs and their metabolites in blood through LC–MS/MS: Application on postmortem samples
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 970 , 1-7, (2014) • The introduction has been modified. • More references have been added to the text. • Limitations of the method have been discussed more in detail. |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Source: NCGC
External Id: SNCA-p-activity-luciferase
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Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273
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Name: Increase the activity of the Burkholderia fixLJ 2-component system
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: Burkholderia multivorans
External Id: HMS1625
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Name: Inhibition of Pdr5p-mediated rhodamine 6G transport in Saccharomyces cerevisiae MKPDR...
Source: ChEMBL
Target: Pleiotropic ABC efflux transporter of multiple drugs
External Id: CHEMBL1696307
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Name: Dissociation constant, pKa by capillary electrophoresis
Source: ChEMBL
Target: N/A
External Id: CHEMBL1023026
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Name: Lipophilicity, log D at pH 7.4 by liquid chromatography
Source: ChEMBL
Target: N/A
External Id: CHEMBL1023023
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Name: Lipophilicity, log P by microemulsion electrokinetic chromatography
Source: ChEMBL
Target: N/A
External Id: CHEMBL1023024
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Name: Alphascreen assay for small molecules abrogating mHTT-CaM Interaction
Source: 24983
Target: Huntingtin
External Id: KUHTS-Muma KU-CaM-Htt INH-01
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| 2-{4-[3-(2-Chlor-10H-phenothiazin-10-yl)propyl]piperazin-1-yl}ethanol |
| 2-{4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]piperazin-1-yl}ethanol |
| 2-(4-(3-(2-Chloro-10H-phenothiazin-10-yl)propyl)piperazin-1-yl)ethanol |
| 2-{4-[3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-1-piperazinyl}ethanol |
| EINECS 200-381-5 |
| Chlorpiprozine |
| 1-(2-Hydroxyethyl)-4-[3-(2-chloro-10-phenothiazinyl)propyl]piperazine |
| 2-Chloro-10-[3-[1-(2-hydroxyethyl)-4-piperazinyl]propyl]phenothiazine |
| 4-[3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-1-piperazineethanol |
| 2-{4-[3-(2-chloro-10H-phénothiazin-10-yl)propyl]pipérazin-1-yl}éthanol |
| Trilafon |
| MFCD00056798 |
| 2-Chloro-10-[3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl]phenothiazine |
| PZC |
| g-[4-(b-Hydroxyethyl)piperazin-1-yl]propyl-2-chlorophenothiazine |
| 2-{4-[3-(2-Chloro-phenothiazin-10-yl)-propyl]-piperazin-1-yl}-ethanol |
| Perphenazine |
| 2-[4-[3-(2-Chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethanol |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the SMILES notation of perphenazine? |
| A: SMILES notation of perphenazine is OCCN1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1. |
| Q: What is the polar surface area (PSA) of perphenazine? |
| A: Polar surface area (PSA) of perphenazine is 55.25000. |
| Q: What are the downstream products of perphenazine? |
| A: Related downstream products(CAS) of perphenazine: 504-07-4;503537-30-2;10078-25-8. |
| Q: What is the CAS number of perphenazine? |
| A: CAS number of perphenazine is 58-39-9. |
| Q: What is the molecular formula of perphenazine? |
| A: Molecular formula of perphenazine is C21H26ClN3OS. |
| Q: What is the InChIKey of perphenazine? |
| A: InChIKey of perphenazine is RGCVKNLCSQQDEP-UHFFFAOYSA-N. |
| Q: What is the safety information for perphenazine? |
| A: Safety information for perphenazine: 28-36/37/39-45. |
| Q: What are the uses of perphenazine? |
| A: Main uses of perphenazine: Perphenazine is a typical antipsychotic drug, inhibits 5-HT2Areceptor, Alpha-1A adrenergic receptor, Dopamine receptor D2/D3, D2L receptor, and Histamine H1 receptor, with Ki values of 5.6, 10, 0.765/0.13, 3.4, and 8 nM, respectively. |
| Q: What is the melting point of perphenazine? |
| A: Melting point of perphenazine is 35339ºC. |
| Q: What is the boiling point of perphenazine? |
| A: Boiling point of perphenazine is 580.4±50.0 °C at 760 mmHg. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |
| Henan Tianfu Chemical Co., Ltd. |