Serotonin-d4

Modify Date: 2024-01-06 18:12:32

Serotonin-d4 structure	Common Name	Serotonin-d4
	CAS Number	58264-95-2	Molecular Weight	180.24
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₀H₈D₄N₂O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Serotonin-d4

Serotonin-d4 is deuterium labeled Serotonin. Serotonin is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin is also a catechol O-methyltransferase (COMT) inhibitor with a Ki of 44 μM.

Name	Serotonin-d4

Description	Serotonin-d4 is deuterium labeled Serotonin. Serotonin is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin is also a catechol O-methyltransferase (COMT) inhibitor with a Ki of 44 μM.
Related Catalog	Signaling Pathways >> Neuronal Signaling >> COMT Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Signaling Pathways >> Metabolic Enzyme/Protease >> COMT
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Tsao D, et al. Serotonin-induced hypersensitivity via inhibition of catechol O-methyltransferase activity. Mol Pain. 2012 Apr 13;8:25. [3]. Shajib MS, et al. Interleukin 13 and serotonin: linking the immune and endocrine systems in murine models of intestinal inflammation. PLoS One. 2013 Aug 28;8(8):e72774.

Molecular Formula	C₁₀H₈D₄N₂O
Molecular Weight	180.24

Serotonin-d4

Use of Serotonin-d4

Names

Serotonin-d4 Biological Activity

Chemical & Physical Properties