Cyclizine dihydrochloride

Modify Date: 2024-01-14 08:44:20

Cyclizine dihydrochloride Structure
Cyclizine dihydrochloride structure
Common Name Cyclizine dihydrochloride
CAS Number 5897-18-7 Molecular Weight 302.84200
Density N/A Boiling Point N/A
Molecular Formula C18H23ClN2 Melting Point N/A
MSDS N/A Flash Point N/A

 Names

Name 1-benzhydryl-4-methyl-piperazine, dihydrochloride
Synonym More Synonyms

 Chemical & Physical Properties

Molecular Formula C18H23ClN2
Molecular Weight 302.84200
Exact Mass 302.15500
PSA 6.48000
LogP 3.70120
Storage condition -20℃

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TL6490000
CHEMICAL NAME :
Piperazine, 1-diphenylmethyl-4-methyl-, dihydrochloride
CAS REGISTRY NUMBER :
5897-18-7
LAST UPDATED :
199606
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C18-H22-N2.2Cl-H
MOLECULAR WEIGHT :
339.34

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
69 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Lungs, Thorax, or Respiration - other changes
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 46,279,1957 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
11928 mg/kg/12W-C
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - chronic pulmonary edema Liver - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 112,297,1954

 Synonyms

Cyclizine dihydrochloride
Cyclizine 2HCl
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