1400W dihydrochloride
Modify Date: 2024-01-20 18:45:37
1400W dihydrochloride structure
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Common Name | 1400W dihydrochloride | ||
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| CAS Number | 214358-33-5 | Molecular Weight | 250.168 | |
| Density | N/A | Boiling Point | 329ºC at 760 mmHg | |
| Molecular Formula | C10H17Cl2N3 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 152.7ºC | |
Use of 1400W dihydrochloride1400W dihydrochloride is a potent and selective inhibitor of human inducible NO synthase with Ki values of 7 nM. |
| Name | 1400W (hydrochloride) |
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| Synonym | More Synonyms |
| Description | 1400W dihydrochloride is a potent and selective inhibitor of human inducible NO synthase with Ki values of 7 nM. |
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| Related Catalog | |
| Target |
Ki: 7 nM (iNOS), 2 µM (nNOS), 50 µM (eNOS)[1] |
| In Vitro | 1400W is a slow, tight binding inhibitor of human inducible nitric- oxide synthase (iNOS). The slow onset of inhibition by 1400W shows saturation kinetics with a maximal rate constant of 0.028 s-1 and a binding constant of 2.0 μM. Inhibition is dependent on the cofactor NADPH. 1400W is at least 5000-fold selective for iNOS versus eNOS. In contrast, inhibition of human neuronal NOS and endothelial NOS (eNOS) is relatively weaker, rapidly reversible, and competitive with L-arginine, with Ki values of 2 μM and 50 μM, respectively[1]. 1400W treatment inhibits iNOS expression without affecting nNOS or eNOS. 1400W also reduces NO, 3-NT and MDA production, and prevents neuronal cell apoptosis in cerebral cortex[2]. |
| In Vivo | 1400W potently (ED50=0.3 mg/kg) reduces the delayed vascular injury in rats attributable to LPS-induced iNOS but fails to exacerbate acute vascular leakage when given concurrently with LPS[1]. Administration of 1400W lowers NOx levels in all the experimental groups. In addition, lipid peroxidation, the percentage of apoptotic cells, and nitrated protein expression fall in the late post-hypoxia period (48 h and 5 days)[3]. |
| Animal Admin | Rats: The effects of 1400W on plasma leakage are assessed in rats by determining the leakage of [125I]human serum albumin from plasma into organs. 1400W (0.1-10 mg/kg, subcutaneous) is dissolved in isotonic saline and administered either concurrently with endotoxin or 3 h following LPS administration (E. coli LPS, 3 mg/kg intravenously). Plasma leakage is then assessed 1 or 5 h after delivery of 1400W[1]. |
| References |
| Boiling Point | 329ºC at 760 mmHg |
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| Molecular Formula | C10H17Cl2N3 |
| Molecular Weight | 250.168 |
| Flash Point | 152.7ºC |
| Exact Mass | 249.079956 |
| PSA | 61.90000 |
| LogP | 4.02700 |
| Vapour Pressure | 0.000183mmHg at 25°C |
| Storage condition | -20℃ |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
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NOS1-dependent negative feedback regulation of the epithelial sodium channel in the collecting duct.
Am. J. Physiol. Renal Physiol. 308(3) , F244-51, (2015) With an increase in urine flow there is a significant increase in shear stress against the renal epithelium including the inner medullary collecting duct, resulting in an increase in nitric oxide (NO)... |
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Gardenamide A Protects RGC-5 Cells from H₂O₂-Induced Oxidative Stress Insults by Activating PI3K/Akt/eNOS Signaling Pathway.
Int. J. Mol. Sci. 16 , 22350-67, (2015) Gardenamide A (GA) protects the rat retinal ganglion (RGC-5) cells against cell apoptosis induced by H₂O₂. The protective effect of GA was completely abrogated by the specific phosphoinositide 3-kinas... |
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Selective inhibition of inducible nitric oxide synthase inhibits tumor growth in vivo: studies with 1400W, a novel inhibitor.
Cancer Res. 57 , 3300, (1997) We have investigated the effect of N-(3-(aminomethyl)benzyl)acetamidine (1400W), a novel and highly selective inhibitor for inducible NOS (iNOS), on in vivo growth of solid tumors expressing iNOS. For... |
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