Procaine structure
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Common Name | Procaine | ||
|---|---|---|---|---|
| CAS Number | 59-46-1 | Molecular Weight | 236.310 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 373.6±22.0 °C at 760 mmHg | |
| Molecular Formula | C13H20N2O2 | Melting Point | 61ºC | |
| MSDS | N/A | Flash Point | 179.8±22.3 °C | |
Use of ProcaineProcaine is a local anesthetic drug of the amino ester group, which acts through multiple targets.Target: OthersProcaine is a local anesthetic of the ester type that has a slow onset and a short duration of action.Procaine (0.01-100 microM) inhibited the 5-HT3 receptor-mediated inward current in the whole-cell patch clamp recording. Procaine appears to produce a competitive inhibition on 5-HT3 receptors with a KD of 1.7 microM [1]. Procaine is a DNA-demethylating agent that produces a 40% reduction in 5-methylcytosine DNA content as determined by high-performance capillary electrophoresis or total DNA enzyme digestion. Procaine can also demethylate densely hypermethylated CpG islands. Procaine also has growth-inhibitory effects in these cancer cells, causing mitotic arrest [2]. Procaine functions as an excitant of limbic system cells, and that procaine alters synaptic transmission in some, but not all, output pathways from the amygdale [3]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | procaine |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Procaine is a local anesthetic drug of the amino ester group, which acts through multiple targets.Target: OthersProcaine is a local anesthetic of the ester type that has a slow onset and a short duration of action.Procaine (0.01-100 microM) inhibited the 5-HT3 receptor-mediated inward current in the whole-cell patch clamp recording. Procaine appears to produce a competitive inhibition on 5-HT3 receptors with a KD of 1.7 microM [1]. Procaine is a DNA-demethylating agent that produces a 40% reduction in 5-methylcytosine DNA content as determined by high-performance capillary electrophoresis or total DNA enzyme digestion. Procaine can also demethylate densely hypermethylated CpG islands. Procaine also has growth-inhibitory effects in these cancer cells, causing mitotic arrest [2]. Procaine functions as an excitant of limbic system cells, and that procaine alters synaptic transmission in some, but not all, output pathways from the amygdale [3]. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 373.6±22.0 °C at 760 mmHg |
| Melting Point | 61ºC |
| Molecular Formula | C13H20N2O2 |
| Molecular Weight | 236.310 |
| Flash Point | 179.8±22.3 °C |
| Exact Mass | 236.152481 |
| PSA | 55.56000 |
| LogP | 2.36 |
| Vapour Pressure | 0.0±0.8 mmHg at 25°C |
| Index of Refraction | 1.543 |
| InChIKey | MFDFERRIHVXMIY-UHFFFAOYSA-N |
| SMILES | CCN(CC)CCOC(=O)c1ccc(N)cc1 |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Hazard Codes | Xi |
|---|---|
| RIDADR | UN 3249 |
| Packaging Group | III |
| Hazard Class | 6.1(b) |
| HS Code | 2922499100 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 10 | |
|---|---|
| DownStream 10 | |
This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2922499990 |
|---|---|
| Summary | HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0% |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| 4-aminobenzoic acid 2-diethylaminoethyl ester |
| 2-(Diethylamino)ethyl 4-aminobenzoate |
| Procaine Base |
| EINECS 200-426-9 |
| β-(Diethylamino)ethyl p-aminobenzoate |
| Benzoic acid, 4-amino-, 2-(diethylamino)ethyl ester |
| Procaine |
| Benzoic acid, p-amino-, 2- (diethylamino)ethyl ester |
| β-Diethylaminoethyl 4-aminobenzoate |
| Benzoic acid, 4-amino-, 2- (diethylamino)ethyl ester |
| 4-Aminobenzoic acid 2-(diethylamino)ethyl ester |
| MFCD00007893 |
| 2-(Diethylamino)ethyl p-aminobenzoate |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What are the upstream materials of procaine? |
| A: Related upstream materials(CAS) of procaine: 38973-67-0;99-77-4;100-37-8;619-45-4;13456-39-8;94-09-7;100-35-6;122-04-3;869-24-9;150-13-0. |
| Q: What are the downstream products of procaine? |
| A: Related downstream products(CAS) of procaine: 54-35-3;21033-42-1;150-13-0;100-37-8;27474-68-6;47662-72-6;59440-80-1;6062-23-3;62276-02-2;63014-02-8. |
| Q: What English synonyms does procaine have? |
| A: English synonyms of procaine: 4-aminobenzoic acid 2-diethylaminoethyl ester, 2-(Diethylamino)ethyl 4-aminobenzoate, Procaine Base, EINECS 200-426-9, β-(Diethylamino)ethyl p-aminobenzoate, Benzoic acid, 4-amino-, 2-(diethylamino)ethyl ester, Procaine, Benzoic acid, p-amino-, 2- (diethylamino)ethyl ester, β-Diethylaminoethyl 4-aminobenzoate, Benzoic acid, 4-amino-, 2- (diethylamino)ethyl ester, 4-Aminobenzoic acid 2-(diethylamino)ethyl ester, MFCD00007893, 2-(Diethylamino)ethyl p-aminobenzoate. |
| Q: What is the CAS number of procaine? |
| A: CAS number of procaine is 59-46-1. |
| Q: What is the molecular weight of procaine? |
| A: Molecular weight of procaine is 236.310. |
| Q: What is the InChIKey of procaine? |
| A: InChIKey of procaine is MFDFERRIHVXMIY-UHFFFAOYSA-N. |
| Q: What is the melting point of procaine? |
| A: Melting point of procaine is 61ºC. |
| Q: What is the molecular formula of procaine? |
| A: Molecular formula of procaine is C13H20N2O2. |
| Q: What is the English name of procaine? |
| A: The English name of procaine is procaine. |
| Q: What is the LogP of procaine? |
| A: LogP of procaine is 2.36. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Henan Tianfu Chemical Co., Ltd. |