Mephenesin

Modify Date: 2024-01-05 12:17:09

Mephenesin Structure
Mephenesin structure
Common Name Mephenesin
CAS Number 59-47-2 Molecular Weight 182.21600
Density 1.152g/cm3 Boiling Point 153ºC(4 torr)
Molecular Formula C10H14O3 Melting Point 69ºC
MSDS N/A Flash Point 161.5ºC

 Use of Mephenesin


Mephenesin is an NMDA receptor antagonist, is a centrally acting muscle relaxant.Target: NMDA receptor

 Names

Name 3-(2-methylphenoxy)propane-1,2-diol
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.152g/cm3
Boiling Point 153ºC(4 torr)
Melting Point 69ºC
Molecular Formula C10H14O3
Molecular Weight 182.21600
Flash Point 161.5ºC
Exact Mass 182.09400
PSA 49.69000
LogP 0.72700
Index of Refraction 1.545
Water Solubility Soluble in alcohol

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TZ1225000
CHEMICAL NAME :
1,2-Propanediol, 3-(o-tolyloxy)-
CAS REGISTRY NUMBER :
59-47-2
BEILSTEIN REFERENCE NO. :
2047373
LAST UPDATED :
199706
DATA ITEMS CITED :
12
MOLECULAR FORMULA :
C10-H14-O3
MOLECULAR WEIGHT :
182.24
WISWESSER LINE NOTATION :
Q1YQ1OR B1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
625 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - antipsychotic Lungs, Thorax, or Respiration - other changes
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 130,280,1961
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
283 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - muscle weakness Behavioral - ataxia
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 129,75,1960
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
133 mg/kg
TOXIC EFFECTS :
Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea Kidney, Ureter, Bladder - hematuria
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 85,323,1954
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
720 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 17,242,1967
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
320 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 55,1272,1959
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
285 mg/kg
TOXIC EFFECTS :
Behavioral - anticonvulsant
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 19,247,1962
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
175 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV. Volume(issue)/page/year: 248,3642,1959
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
2300 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 89,145,1952
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
125 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - altered sleep time (including change in righting reflex) Behavioral - rigidity (including catalepsy)
REFERENCE :
IJNEAQ International Journal of Neuropharmacology. (New York, NY) V.1-8, 1962-69. For publisher information, see NEPHBW. Volume(issue)/page/year: 5,305,1966
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - hamster
DOSE/DURATION :
821 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - muscle weakness Behavioral - ataxia
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 129,75,1960
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - hamster
DOSE/DURATION :
322 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - muscle weakness Behavioral - ataxia
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 129,75,1960 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84506 No. of Facilities: 166 (estimated) No. of Industries: 3 No. of Occupations: 9 No. of Employees: 3053 (estimated)

 Safety Information

Hazard Codes Xn
Risk Phrases 22-36
Safety Phrases 26
WGK Germany 2
RTECS TZ1225000
HS Code 2909309090

 Synthetic Route

~96%

Mephenesin Structure

Mephenesin

CAS#:59-47-2

Literature: Hadimani, Mallinath B.; Purohit, Meena K.; Vanampally, Chandrashaker; Van Der Ploeg, Randy; Arballo, Victor; Morrow, Dwane; Frizzi, Katie E.; Calcutt, Nigel A.; Fernyhough, Paul; Kotra, Lakshmi P. Journal of Medicinal Chemistry, 2013 , vol. 56, # 12 p. 5071 - 5078

~64%

Mephenesin Structure

Mephenesin

CAS#:59-47-2

Literature: Seth, Kapileswar; Roy, Sudipta Raha; Pipaliya, Bhavin V.; Chakraborti, Asit K. Chemical Communications, 2013 , vol. 49, # 52 p. 5886 - 5888

~%

Mephenesin Structure

Mephenesin

CAS#:59-47-2

Literature: Yakugaku Zasshi, , vol. 74, p. 1273 Chem.Abstr., , p. 14668

~%

Mephenesin Structure

Mephenesin

CAS#:59-47-2

Literature: Journal of the American Chemical Society, , vol. 72, p. 3716

~%

Mephenesin Structure

Mephenesin

CAS#:59-47-2

Literature: Van Elburg; Ormskerk; De Kloe; Boogaard Journal of Labelled Compounds and Radiopharmaceuticals, 2000 , vol. 43, # 2 p. 147 - 167

~%

Mephenesin Structure

Mephenesin

CAS#:59-47-2

Literature: Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 43, # 2 p. 147 - 167

~%

Mephenesin Structure

Mephenesin

CAS#:59-47-2

Literature: Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 43, # 2 p. 147 - 167

~%

Mephenesin Structure

Mephenesin

CAS#:59-47-2

Literature: Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 43, # 2 p. 147 - 167

~%

Mephenesin Structure

Mephenesin

CAS#:59-47-2

Literature: Journal of Pharmacy and Pharmacology, , vol. 10, p. 47,59

 Customs

HS Code 2909309090
Summary 2909309090 other aromatic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

 Synonyms

Myodetensine
Mefenesina
3-o-tolyloxypropane-1,2-diol
Anatensin
Decontractyl
Lissenphan
3-(o-tolyloxy)-1,2-propanediol
Cresoxydiol
mephenesin
Decontractil
3-(2-methylphenoxy)-propane-1,2-diol
Cresodiol
Lissephen
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