Mephenesin

Modify Date: 2026-07-07 19:34:15

Mephenesin structure	Common Name	Mephenesin
	CAS Number	59-47-2	Molecular Weight	182.21600
	Density	1.152g/cm3	Boiling Point	153ºC(4 torr)
	Molecular Formula	C₁₀H₁₄O₃	Melting Point	69ºC
	MSDS	N/A	Flash Point	161.5ºC

Use of Mephenesin

Mephenesin is an NMDA receptor antagonist, is a centrally acting muscle relaxant.Target: NMDA receptor

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	3-(2-methylphenoxy)propane-1,2-diol
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	Mephenesin is an NMDA receptor antagonist, is a centrally acting muscle relaxant.Target: NMDA receptor
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease
References	[1]. Mephenesin: abuse and dependence. Prescrire Int. 2013 May;22(138):127-128. [2]. ?cija P, et al. Conformational flexibility of mephenesin. J Phys Chem B. 2014 May 22;118(20):5357-5364.

Description

Mephenesin is an NMDA receptor antagonist, is a centrally acting muscle relaxant.Target: NMDA receptor

Related Catalog

Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

Signaling Pathways >> Neuronal Signaling >> iGluR

Research Areas >> Neurological Disease

References

[1]. Mephenesin: abuse and dependence. Prescrire Int. 2013 May;22(138):127-128.

[2]. ?cija P, et al. Conformational flexibility of mephenesin. J Phys Chem B. 2014 May 22;118(20):5357-5364.

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.152g/cm3
Boiling Point	153ºC(4 torr)
Melting Point	69ºC
Molecular Formula	C₁₀H₁₄O₃
Molecular Weight	182.21600
Flash Point	161.5ºC
Exact Mass	182.09400
PSA	49.69000
LogP	0.72700
Index of Refraction	1.545
InChIKey	JWDYCNIAQWPBHD-UHFFFAOYSA-N
SMILES	Cc1ccccc1OCC(O)CO
Water Solubility	Soluble in alcohol

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

Mephenesin MSDS(Chinese)

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TZ1225000

CHEMICAL NAME :: 1,2-Propanediol, 3-(o-tolyloxy)-

CAS REGISTRY NUMBER :: 59-47-2

BEILSTEIN REFERENCE NO. :: 2047373

LAST UPDATED :: 199706

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C10-H14-O3

MOLECULAR WEIGHT :: 182.24

WISWESSER LINE NOTATION :: Q1YQ1OR B1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 625 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - antipsychotic Lungs, Thorax, or Respiration - other changes

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 130,280,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 283 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - muscle weakness Behavioral - ataxia

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 129,75,1960

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 133 mg/kg

TOXIC EFFECTS :: Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea Kidney, Ureter, Bladder - hematuria

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 85,323,1954

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 720 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 17,242,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 320 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 55,1272,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 285 mg/kg

TOXIC EFFECTS :: Behavioral - anticonvulsant

REFERENCE :: APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 19,247,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 175 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV. Volume(issue)/page/year: 248,3642,1959

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2300 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex)

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 89,145,1952

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 125 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - altered sleep time (including change in righting reflex) Behavioral - rigidity (including catalepsy)

REFERENCE :: IJNEAQ International Journal of Neuropharmacology. (New York, NY) V.1-8, 1962-69. For publisher information, see NEPHBW. Volume(issue)/page/year: 5,305,1966

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 821 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - muscle weakness Behavioral - ataxia

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 129,75,1960

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 322 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - muscle weakness Behavioral - ataxia

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 129,75,1960 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84506 No. of Facilities: 166 (estimated) No. of Industries: 3 No. of Occupations: 9 No. of Employees: 3053 (estimated)

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Hazard Codes	Xn
Risk Phrases	22-36
Safety Phrases	26
WGK Germany	2
RTECS	TZ1225000
HS Code	2909309090

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

o-cresol

CAS#:95-48-7

3-Chloro-1,2-pr...

CAS#:96-24-2

~96%

Mephenesin

CAS#:59-47-2

Learn More

Literature: Hadimani, Mallinath B.; Purohit, Meena K.; Vanampally, Chandrashaker; Van Der Ploeg, Randy; Arballo, Victor; Morrow, Dwane; Frizzi, Katie E.; Calcutt, Nigel A.; Fernyhough, Paul; Kotra, Lakshmi P. Journal of Medicinal Chemistry, 2013 , vol. 56, # 12 p. 5071 - 5078

Glycidol

CAS#:556-52-5

o-cresol

CAS#:95-48-7

~64%

Mephenesin

CAS#:59-47-2

Learn More

Literature: Seth, Kapileswar; Roy, Sudipta Raha; Pipaliya, Bhavin V.; Chakraborti, Asit K. Chemical Communications, 2013 , vol. 49, # 52 p. 5886 - 5888

o-cresol

CAS#:95-48-7

Glycerol

CAS#:56-81-5

Mephenesin

CAS#:59-47-2

Learn More

Literature: Yakugaku Zasshi, , vol. 74, p. 1273 Chem.Abstr., , p. 14668

3-Chloro-1,2-pr...

CAS#:96-24-2

sodium,2-methyl...

CAS#:4549-72-8

Mephenesin

CAS#:59-47-2

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Literature: Journal of the American Chemical Society, , vol. 72, p. 3716

3-(o-Tolyloxy)-...

CAS#:63991-86-6

Mephenesin

CAS#:59-47-2

Learn More

Literature: Van Elburg; Ormskerk; De Kloe; Boogaard Journal of Labelled Compounds and Radiopharmaceuticals, 2000 , vol. 43, # 2 p. 147 - 167

1-chloro-3-(2-m...

CAS#:25772-91-2

Mephenesin

CAS#:59-47-2

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Literature: Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 43, # 2 p. 147 - 167

2-[(2-Methylphe...

CAS#:2210-79-9

Mephenesin

CAS#:59-47-2

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Literature: Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 43, # 2 p. 147 - 167

o-cresol

CAS#:95-48-7

Mephenesin

CAS#:59-47-2

Learn More

Literature: Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 43, # 2 p. 147 - 167

Epichlorohydrin

CAS#:106-89-8

Mephenesin

CAS#:59-47-2

Learn More

Literature: Journal of Pharmacy and Pharmacology, , vol. 10, p. 47,59

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 9
CAS#:95-48-7 o-cresol CAS#:96-24-2 3-Chloro-1,2-pr... CAS#:556-52-5 Glycidol CAS#:56-81-5 Glycerol
CAS#:4549-72-8 sodium,2-methyl... CAS#:63991-86-6 3-(o-Tolyloxy)-... CAS#:25772-91-2 1-chloro-3-(2-m... CAS#:2210-79-9 2-[(2-Methylphe...
CAS#:106-89-8 Epichlorohydrin
DownStream 5
CAS#:101693-39-4 (2R)-2-[(2-METH... CAS#:6055-48-7 Toloxychlorinol CAS#:6288-77-3 [2-hydroxy-3-(2... CAS#:6288-82-0 2-methyl-4-[(2-...
CAS#:533-06-2 1,2-Propanediol...

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code	2909309090
Summary	2909309090 other aromatic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Source: NCGC
External Id: SNCA-p-activity-luciferase

Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273

Name: Increase the activity of the Burkholderia fixLJ 2-component system
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: Burkholderia multivorans
External Id: HMS1625

Name: Dicer-mediated maturation of pre-microRNA
Source: Center for Chemical Genomics, University of Michigan
Target: N/A
External Id: TargetID_659_CEMA

Name: p53 small molecule agonists, cell-based qHTS assay: qHTS cell viability counter scree...
Source: 824
Target: N/A
External Id: P53600

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: qHTS ce...
Source: 824
Target: N/A
External Id: P53MS958

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: Summary
Source: 824
External Id: P53MS482

Name: p53 small molecule agonists, cell-based qHTS assay
Source: 824
External Id: P53344

Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS233

Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes: qHTS ...
Source: 824
Target: N/A
External Id: P53MS837

Total 343, Current Page 1 of 35

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

Myodetensine

Mefenesina

3-o-tolyloxypropane-1,2-diol

Anatensin

Decontractyl

Lissenphan

3-(o-tolyloxy)-1,2-propanediol

Cresoxydiol

mephenesin

Decontractil

3-(2-methylphenoxy)-propane-1,2-diol

Cresodiol

Lissephen

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the LogP of 3-(2-methylphenoxy)propane-1,2-diol?

A: LogP of 3-(2-methylphenoxy)propane-1,2-diol is 0.72700.

Q: What is the InChIKey of 3-(2-methylphenoxy)propane-1,2-diol?

A: InChIKey of 3-(2-methylphenoxy)propane-1,2-diol is JWDYCNIAQWPBHD-UHFFFAOYSA-N.

Q: What is the polar surface area (PSA) of 3-(2-methylphenoxy)propane-1,2-diol?

A: Polar surface area (PSA) of 3-(2-methylphenoxy)propane-1,2-diol is 49.69000.

Q: What is the melting point of 3-(2-methylphenoxy)propane-1,2-diol?

A: Melting point of 3-(2-methylphenoxy)propane-1,2-diol is 69ºC.

Q: What is the safety information for 3-(2-methylphenoxy)propane-1,2-diol?

A: Safety information for 3-(2-methylphenoxy)propane-1,2-diol: 26.

Q: What is the SMILES notation of 3-(2-methylphenoxy)propane-1,2-diol?

A: SMILES notation of 3-(2-methylphenoxy)propane-1,2-diol is Cc1ccccc1OCC(O)CO.

Q: What is the molecular formula of 3-(2-methylphenoxy)propane-1,2-diol?

A: Molecular formula of 3-(2-methylphenoxy)propane-1,2-diol is C10H14O3.

Q: What English synonyms does 3-(2-methylphenoxy)propane-1,2-diol have?

A: English synonyms of 3-(2-methylphenoxy)propane-1,2-diol: Myodetensine, Mefenesina, 3-o-tolyloxypropane-1,2-diol, Anatensin, Decontractyl, Lissenphan, 3-(o-tolyloxy)-1,2-propanediol, Cresoxydiol, mephenesin, Decontractil, 3-(2-methylphenoxy)-propane-1,2-diol, Cresodiol, Lissephen.

Q: What is the boiling point of 3-(2-methylphenoxy)propane-1,2-diol?

A: Boiling point of 3-(2-methylphenoxy)propane-1,2-diol is 153ºC(4 torr).

Q: What is the English name of 3-(2-methylphenoxy)propane-1,2-diol?

A: The English name of 3-(2-methylphenoxy)propane-1,2-diol is 3-(2-methylphenoxy)propane-1,2-diol.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

Henan Tianfu Chemical Co., Ltd.

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Mephenesin
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: MEPHENESIN
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

Get all suppliers and price by the below link:

Mephenesin suppliers

Price: $73/10mM*1mLinDMSO

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.