Betaine Hydrochloride

Modify Date: 2026-07-24 08:24:34

Betaine Hydrochloride Structure
Betaine Hydrochloride structure
 Common Name Betaine Hydrochloride
CAS Number 590-46-5 Molecular Weight 153.607
Density 1 g/cm3 Boiling Point N/A
Molecular Formula C5H12ClNO2 Melting Point 241-242 °C(lit.)
MSDS Chinese USA Flash Point N/A
Symbol GHS07
GHS07		 Signal Word Warning

 Use of Betaine Hydrochloride


Betaine hydrochloride is a natural compound found in many foods and also an active methyl-donor which can maintain normal DNA methylation patterns.

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name Betaine hydrochloride
Synonym More Synonyms

 Betaine Hydrochloride Biological Activity

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description Betaine hydrochloride is a natural compound found in many foods and also an active methyl-donor which can maintain normal DNA methylation patterns.
Related Catalog
In Vitro It is found that proliferation of HeLa cells is inhibited significantly upon exposure to increasing Betaine hydrochloride levels with the MTT test (p<0.05). The percentage of S phase cells in the low dose groups (<5 mg/mL) are distinctly higher than in high dose groups, and the rates of Sub-G1 phase are the opposite (p<0.05). A high concentration of Betaine hydrochloride (>5.0 mg/mL) significantly promotes the apoptosis of HeLa cells (p<0.01). SOD activities of the low dose groups are slightly higher than the control group (p<0.05), and there are obvious synchronicity and correlation among the expression of promoting apoptosis genes Bax, P53, Caspase 3 and apoptosis suppression gene Bcl-2. In response to an apoptosis-inducing stimulus, p53 and cyclin D1 can be activated with blockage of the cell cycle at G1/S or S/G2 checkpoints[1].
In Vivo Liver-to-body weight ratio is attenuated by Betaine hydrochloride supplementation. When Betaine hydrochloride is added to the alcohol-containing liquid diet, both hepatic triglyceride (TG) accumulation and liver injury are significantly reduced. Betaine hydrochloride supplementation attenuates epididymal fat pad mass loss induced by chronic alcohol feeding. Betaine hydrochloride supplementation prevents the depletion of S-adenosylhomocysteine (SAM) and reduces the increase in S-adenosylhomocysteine (SAH), thereby improving the methylation state of the adipose tissue[2].
Cell Assay Cytotoxic effects of Betaine hydrochloride are evaluated by MTT assays. Briefly, 5×103 HeLa or MCF-10A cells/well are seeded in a 96-well plate and cultured overnight. Then, different concentrations of Betaine hydrochloride (from 0 to 100 mg/mL) are added to each well, and the MTT assay is performed at 24, 48, 72 and 96 h after incubation. Cu/Zn-SOD activities are detected using the superoxide dismutase Assay Kit according to the manufacturer’s instructions[1].
Animal Admin Male C57BL/6 mice weighing 25±0.5 g are used in this study. Animals are randomly assigned to four groups (n=6 to 8 per group) and pair-fed a modified Lieber-DeCarli alcohol (AF) or isocaloric maltose dextrin control liquid diet (PF) for 5 weeks with a stepwise feeding procedure. The ethanol content starts at 30% of total calories and gradually increases up to 36% in the last week. Betaine hydrochloride is administered as a supplement in the liquid diets (both PF and AF) at a concentration of 0.5% (w/v), simultaneously with the alcohol. All animals have access to diet and water ad libitum. At the end of the experiment, the mice are killed after being deprived of food for 4 h, and the plasma, liver and epididymal fat pad samples are harvested for assays[2].
References

[1]. Guo Y, et al. Betaine Effects on Morphology, Proliferation, and p53-induced Apoptosis of HeLa Cervical Carcinoma Cells in Vitro. Asian Pac J Cancer Prev. 2015;16(8):3195-201.

[2]. Dou X, et al. Rectification of impaired adipose tissue methylation status and lipolytic response contributes to hepatoprotective effect of betaine in a mouse model of alcoholic liver disease. Br J Pharmacol. 2014 Sep;171(17):4073-86.

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density 1 g/cm3
Melting Point 241-242 °C(lit.)
Molecular Formula C5H12ClNO2
Molecular Weight 153.607
Exact Mass 153.055649
PSA 37.30000
InChIKey HOPSCVCBEOCPJZ-UHFFFAOYSA-N
SMILES C[N+](C)(C)CC(=O)O.[Cl-]
Water Solubility 64.7 g/100 mL (25 ºC)

 MSDS

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

 Toxicological Information

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
BP3136000
CHEMICAL NAME :
Ammonium, (carboxymethyl)trimethyl-, chloride
CAS REGISTRY NUMBER :
590-46-5
LAST UPDATED :
199709
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C5-H12-N-O2.Cl

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
8 gm/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - fluid intake Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
ABMGAJ Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.) V.1-41, 1958-82. For publisher information, see BBIADT. Volume(issue)/page/year: 3,28,1959 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80382 No. of Facilities: 112 (estimated) No. of Industries: 3 No. of Occupations: 10 No. of Employees: 3807 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80382 No. of Facilities: 204 (estimated) No. of Industries: 11 No. of Occupations: 23 No. of Employees: 4634 (estimated) No. of Female Employees: 2460 (estimated)

 Safety Information

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H319
Precautionary Statements P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi, Xn
Risk Phrases R36
Safety Phrases S26-S39-S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS BP3136000
HS Code 2923900090

 Synthetic Route

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

Chloroacetic acid structure

Chloroacetic acid

CAS#:79-11-8

Trimethylamine structure

Trimethylamine

CAS#:75-50-3

~%

Betaine Hydrochloride Structure

Betaine Hydroch...

CAS#:590-46-5

Learn More
Literature: US2006/9656 A1, ; Page/Page column 2-3 ;
(2,2,3,3,4,4,5,5-Octafluoropentyl)trimethylammonium iodide structure

(2,2,3,3,4,4,5,...

CAS#:116826-69-8

~95%

Betaine Hydrochloride Structure

Betaine Hydroch...

CAS#:590-46-5

Learn More
Literature: Yamanaka, Hiroki; Yamashita, Seiji; Fukunishi, Koushi; Kuwabara, Masaki; Ishihara, Takashi; Nomura, Mototeru Journal of Fluorine Chemistry, 1991 , vol. 52, # 2 p. 185 - 194
Methyl glycinate structure

Methyl glycinate

CAS#:616-34-2

~%

Betaine Hydrochloride Structure

Betaine Hydroch...

CAS#:590-46-5

Learn More
Literature: DE269751 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 11, p. 119
(2,2,3,3,3-Pentafluoropropyl)trimethylammonium iodide structure

(2,2,3,3,3-Pent...

CAS#:128229-01-6

~19%

Betaine Hydrochloride Structure

Betaine Hydroch...

CAS#:590-46-5

(2,2-Dihydroxy-3,3,3-trifluoropropyl)trimethylammonium iodide structure

(2,2-Dihydroxy-...

CAS#:85219-42-7

Learn More
Literature: Journal of Fluorine Chemistry, , vol. 52, # 2 p. 185 - 194
(2,2,3,3,3-Pentafluoropropyl)trimethylammonium iodide structure

(2,2,3,3,3-Pent...

CAS#:128229-01-6

~%

Betaine Hydrochloride Structure

Betaine Hydroch...

CAS#:590-46-5

Learn More
Literature: Journal of Fluorine Chemistry, , vol. 52, # 2 p. 185 - 194
N/A structure

N/A

CAS#:116826-71-2

~%

1,1,2,2,3,3,4,4,5,5-decafluoropentane structure

1,1,2,2,3,3,4,4...

CAS#:755-23-7

Betaine Hydrochloride Structure

Betaine Hydroch...

CAS#:590-46-5

Learn More
Literature: Journal of Fluorine Chemistry, , vol. 52, # 2 p. 185 - 194
trimethyl-((Z)-2,3,3,3-tetrafluoro-1-propenyl)ammonium iodide structure

trimethyl-((Z)-...

CAS#:128229-02-7

~%

Betaine Hydrochloride Structure

Betaine Hydroch...

CAS#:590-46-5

(2,2-Dihydroxy-3,3,3-trifluoropropyl)trimethylammonium iodide structure

(2,2-Dihydroxy-...

CAS#:85219-42-7

Learn More
Literature: Journal of Fluorine Chemistry, , vol. 52, # 2 p. 185 - 194

 Customs

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code 2923900090
Summary 2923900090 other quaternary ammonium salts and hydroxides。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

 Articles69

More Articles

This table lists relevant public references with title, journal and publication metadata for this compound.

Sulfur amino acid metabolism in Zucker diabetic fatty rats.

Biochem. Pharmacol. 96 , 256-66, (2015)

The present study was aimed to investigate the metabolomics of sulfur amino acids in Zucker diabetic fatty (ZDF) rats, an obese type 2 diabetic animal model. Plasma levels of total cysteine, homocyste...

Developing structure-activity relationships for the prediction of hepatotoxicity.

Chem. Res. Toxicol. 23 , 1215-22, (2010)

Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals ...

A predictive ligand-based Bayesian model for human drug-induced liver injury.

Drug Metab. Dispos. 38 , 2302-8, (2010)

Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predicti...

 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

(Trimethylammonio)acetate hydrochloride
EINECS 209-683-1
Acinorm
lycine hydrochloride
ACIDOL
Betaine Hydrochloride
Achylin
Betaine, hydrochloride
Pluchine
BET HCL
1-carboxy-n,n,n-trimethylmethanaminium chloride
Acidin
Methanaminium, 1-carboxy-N,N,N-trimethyl-, chloride (1:1)
Euacid
MFCD00011903
Achyin
Carboxy-N,N,N-trimethylmethanaminium chloride
betainium chloride
Acidine
Muriat
carboxymethyl-trimethyl-ammonium chloride
(Trimethylammonio)acetathydrochlorid
betaine chloride
betain hydrochloride
Betaine (hydrochloride)

 Betaine Hydrochloride | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: How is the water solubility of Betaine hydrochloride?
A: Water solubility of Betaine hydrochloride: 64.7 g/100 mL (25 ºC).
Q: What are the upstream materials of Betaine hydrochloride?
A: Related upstream materials(CAS) of Betaine hydrochloride: 79-11-8;75-50-3;616-34-2;128229-01-6.
Q: What is the English name of Betaine hydrochloride?
A: The English name of Betaine hydrochloride is Betaine hydrochloride.
Q: What is the molecular formula of Betaine hydrochloride?
A: Molecular formula of Betaine hydrochloride is C5H12ClNO2.
Q: What is the melting point of Betaine hydrochloride?
A: Melting point of Betaine hydrochloride is 241-242 °C(lit.).
Q: What is the InChIKey of Betaine hydrochloride?
A: InChIKey of Betaine hydrochloride is HOPSCVCBEOCPJZ-UHFFFAOYSA-N.
Q: What are the uses of Betaine hydrochloride?
A: Main uses of Betaine hydrochloride: Betaine hydrochloride is a natural compound found in many foods and also an active methyl-donor which can maintain normal DNA methylation patterns.
Q: What is the polar surface area (PSA) of Betaine hydrochloride?
A: Polar surface area (PSA) of Betaine hydrochloride is 37.30000.
Q: What is the safety information for Betaine hydrochloride?
A: Safety information for Betaine hydrochloride: S26-S39-S24/25.
Q: What is the CAS number of Betaine hydrochloride?
A: CAS number of Betaine hydrochloride is 590-46-5.

 Betaine Hydrochloridefactory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd
Dayang Chem (Hangzhou) Co., Ltd.
naturewill
Henan Tianfu Chemical Co., Ltd.
Zhongshan Xingrui Chemical Co. , Ltd.
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.
Top Suppliers:I want be here

Get all suppliers and price by the below link:

Betaine Hydrochloride suppliers

Price: ￥57/100g

Reference only. check more Betaine Hydrochloride price

Related Compounds: More...
2-Chloro-N-[[1-(1,2,4-oxadiazol-3-ylmethyl)piperidin-3-yl]methyl]propanamide
2411294-68-1
2-Chloro-N-(2-hydroxyethyl)-N-(2-pyridin-2-yloxyethyl)propanamide
2411299-74-4
2-{[1-(2-Chloropropanoyl)azetidin-3-yl]formamido}-2-ethylbutanamide
2411221-93-5
2-Chloro-1-[(2R)-4-ethylsulfonyl-2-methylpiperazin-1-yl]propan-1-one
2411184-20-6
2-Chloro-N-[[1-(methoxymethyl)-3,4-dihydroisochromen-1-yl]methyl]propanamide
2411275-91-5
2-Chloro-N-[[(2R,5R)-5-phenyloxolan-2-yl]methyl]propanamide
2411183-57-6
2-Chloro-N-[[1-(hydroxymethyl)-2-phenylcyclopropyl]methyl]propanamide
2411198-61-1
2-Chloro-N-(3-(2,4-dioxo-1,3-diazaspiro[4.4]nonan-3-yl)benzyl)propanamide
2411260-96-1
2-Chloro-N-[2-cyclopentyl-2-(dimethylsulfamoylamino)ethyl]propanamide
2411223-60-2
N-[[1-(2-Chloropropanoyl)piperidin-3-yl]methyl]cyclopropanesulfonamide
2411296-83-6
Chemsrc provides Betaine Hydrochloride(CAS#:590-46-5) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Betaine Hydrochloride are included as well.>> amp version: Betaine Hydrochloride

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2026 ChemSrc All Rights Reserved